Navigation Links
Scientists show how cells protect their DNA from catastrophic damage
Date:11/21/2013

Researchers at the University of Copenhagen have unveiled a profound biological process that explains how DNA can be damaged during genome replication. In addition, the scientists developed a new analytical tool to measure the cell's response to chemotherapy, which could have an important impact on future cancer therapy. The results are now published in the scientific journal Cell.

An international team of researchers led by Professor Jiri Lukas from the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen have unveiled a process that explains how DNA can be damaged during genome replication, due to the lack of a critical protein.

Cells need to keep their genomic DNA unharmed to stay healthy and the scientists were able to visualize the process of DNA replication and damage directly in cells with an unprecedented detail. They discovered a fundamental mechanism of how proteins protect chromosomes while DNA is being copied (a process called DNA replication), which relies on a protein called RPA. Cells have a limited amount of this protein, which they use as 'band aids' to protect the DNA temporarily during replication. If they use up the RPA reservoir, their DNA breaks severely and cells are no longer able to divide.

"We now understand that many drugs used in chemotherapy are toxic against tumours because they make DNA replication difficult and force cancer cells to consume their RPA pool much faster than normal cells usually do. As a result, cancer cells are constantly at the verge of falling into a 'replication catastrophe', a condition from which they cannot recover, and which can be used as a powerful means to selectively eliminate cancer cells," says Luis Ignacio Toledo, the first author of this study.

Future impact on cancer diagnosis and treatment

In addition to helping other scientists to comprehend some of the most fundamental processes in cell physiology, the findings could have important implications for cancer diagnosis and treatment by helping understand, at the molecular level, what makes cancer cells different from normal cells.

"The relevance of our discovery is that it provides an explanation for a broad spectrum of previous scientific observations, which on the first glance seemed unrelated, but which we now show can be unified into a simple comprehensive model to understand how proteins protect DNA from catastrophic damage," concludes Luis Ignacio Toledo.


'/>"/>

Contact: Luis Ignacio Toledo
luis.toledo@cpr.ku.dk
45-31-10-19-66
University of Copenhagen
Source:Eurekalert

Related medicine news :

1. Scientists far from finish line in understanding anemia in female athletes
2. LSUHSC faculty shares inside knowledge in book to develop nations research scientists
3. Renowned Scientists Join Cure Alzheimer’s Fund’s Search for Alzheimer’s Therapies
4. Scientists fingerprint single cancer cells to map cancers family tree
5. A*STAR scientists bring to light mechanism of drug for infections
6. NSF International Scientists Announce Discovery of New Bacterium, Same Family as E. coli and Klebsiella Pneumonia
7. CNIO scientists decipher how the immune system induces liver damage during hepatitis
8. A*STAR scientists uncover potential drug target to nip cancer in the bud
9. Volunteers join scientists in finding out who gets rid of cow dung
10. Scientists at Cancer Prevention Institute of California Find That a Diet High in Fruits and Vegetables May Significantly Reduce Risk of Breast Cancer
11. Leicester scientists map structure of key complex in the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2017)... ... ... In a continuous effort to raise awareness of autism and common toxins found ... natural and organic latex mattresses, has announced that they will donate $1 to the ... recent viral Facebook video receives, up to $10,000.00. , The luxury online ...
(Date:5/19/2017)... ... May 19, 2017 , ... DMG Productions is ... of Innovations with Ed Begley, Jr., airing fourth quarter 2017 on FOX Business. ... clean, organic dietary supplement made from naturally occurring ingredients. Innovations will enlighten viewers ...
(Date:5/19/2017)... ... May 19, 2017 , ... Springfield, Vermont-based law firm of Brady/Callahan has ... Good Reasons To Hire An Experienced Personal Injury Attorney, " the article offers insight ... injury. As the article says. if someone is injured due to another person's ...
(Date:5/19/2017)... ... May 19, 2017 , ... The Miller Agency, a ... families and business owners in the region, is embarking on a cooperative charity ... their families. , Multiple sclerosis (MS) is a demyelinating disease that affects the ...
(Date:5/19/2017)... (PRWEB) , ... May 19, 2017 , ... ... containerization, today announced a sponsorship and speaking session at the 7th Annual ... the longest-running hosted enterprise mobility and digital transformation conference whose expressed purpose is ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... 10, 2017  The Corporate Whistleblower Center says, ... sleep therapy clinics to call us anytime at ... is involved in a substantial scheme to overbill ... from an employee of a medical equipment company ... to provide medical practice groups with extra generous incentives ...
(Date:5/9/2017)... , May 9, 2017  Demonstrating its ... board of directors for the Pharmaceutical Research and ... for membership. Biopharmaceutical companies will now have to ... order to be eligible to join PhRMA. ... the board is sending a clear message that ...
(Date:5/8/2017)... FLINT, Mich. , May 8, 2017  Diplomat ... WRB Communications, Inc. ("WRB"), a health care ... . WRB specializes in relationship management ... organizations. WRB will ... of Diplomat,s commercialization support services for manufacturers, biotech firms, ...
Breaking Medicine Technology: