Navigation Links
Scientists show how cells protect their DNA from catastrophic damage

Researchers at the University of Copenhagen have unveiled a profound biological process that explains how DNA can be damaged during genome replication. In addition, the scientists developed a new analytical tool to measure the cell's response to chemotherapy, which could have an important impact on future cancer therapy. The results are now published in the scientific journal Cell.

An international team of researchers led by Professor Jiri Lukas from the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen have unveiled a process that explains how DNA can be damaged during genome replication, due to the lack of a critical protein.

Cells need to keep their genomic DNA unharmed to stay healthy and the scientists were able to visualize the process of DNA replication and damage directly in cells with an unprecedented detail. They discovered a fundamental mechanism of how proteins protect chromosomes while DNA is being copied (a process called DNA replication), which relies on a protein called RPA. Cells have a limited amount of this protein, which they use as 'band aids' to protect the DNA temporarily during replication. If they use up the RPA reservoir, their DNA breaks severely and cells are no longer able to divide.

"We now understand that many drugs used in chemotherapy are toxic against tumours because they make DNA replication difficult and force cancer cells to consume their RPA pool much faster than normal cells usually do. As a result, cancer cells are constantly at the verge of falling into a 'replication catastrophe', a condition from which they cannot recover, and which can be used as a powerful means to selectively eliminate cancer cells," says Luis Ignacio Toledo, the first author of this study.

Future impact on cancer diagnosis and treatment

In addition to helping other scientists to comprehend some of the most fundamental processes in cell physiology, the findings could have important implications for cancer diagnosis and treatment by helping understand, at the molecular level, what makes cancer cells different from normal cells.

"The relevance of our discovery is that it provides an explanation for a broad spectrum of previous scientific observations, which on the first glance seemed unrelated, but which we now show can be unified into a simple comprehensive model to understand how proteins protect DNA from catastrophic damage," concludes Luis Ignacio Toledo.


Contact: Luis Ignacio Toledo
University of Copenhagen

Related medicine news :

1. Scientists far from finish line in understanding anemia in female athletes
2. LSUHSC faculty shares inside knowledge in book to develop nations research scientists
3. Renowned Scientists Join Cure Alzheimer’s Fund’s Search for Alzheimer’s Therapies
4. Scientists fingerprint single cancer cells to map cancers family tree
5. A*STAR scientists bring to light mechanism of drug for infections
6. NSF International Scientists Announce Discovery of New Bacterium, Same Family as E. coli and Klebsiella Pneumonia
7. CNIO scientists decipher how the immune system induces liver damage during hepatitis
8. A*STAR scientists uncover potential drug target to nip cancer in the bud
9. Volunteers join scientists in finding out who gets rid of cow dung
10. Scientists at Cancer Prevention Institute of California Find That a Diet High in Fruits and Vegetables May Significantly Reduce Risk of Breast Cancer
11. Leicester scientists map structure of key complex in the immune system
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... Brenntag ... exclusive channel partner for the Nutraceutical Specialties products into oral solid dosage in ... immediately. , “We are pleased to announce our expanded distribution agreement with ...
(Date:11/30/2015)... ... November 30, 2015 , ... An inventor from Charlottesville, Va., is concerned ... last baby had high blood pressure due to loud noises," she said, "so I ... from noise pollution as well as radio waves and microwaves." , The baby BABY ...
(Date:11/30/2015)... ... November 30, 2015 , ... Since its inception, ... in independent living, assisted living and all other retirement options. Support for issues ... and research remains a top priority. , So it’s no surprise that ...
(Date:11/30/2015)... ... November 30, 2015 , ... Sikka Software announced today that they ... Ecosystem empowers dentists to make complex business decisions by providing the tools and information ... free fee survey with 10 procedures customized by zip code. , The Sikka ...
(Date:11/30/2015)... ... November 30, 2015 , ... Healthjump, Inc. announced ... a Healthcare IT consulting, development and support company. The purchase will expand the ... within DataTrade to extend the services currently provided by Healthjump. , ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 2015   Royal Philips (NYSE: PHG ... first MRI guided user interface and automatic scan parameter ... MR Conditional implants, such as knee and hip replacements, ... Society of North America Annual Meeting (RSNA) . The ... confidence of this growing patient population. ScanWise Implant adds ...
(Date:11/30/2015)... PUNE, India , November 30, 2015 ... in 2014, and is expected to grow at a CAGR of ... was valued at USD 135.6 million in 2014, and ... to 2020. --> According to the new Market Research ... Minimally invasive, non-invasive), By End User (Hospitals, ambulatory care, others) - ...
(Date:11/30/2015)... the Six Months Ended 30 September 2015 2014RestatedChange%Turnover 545,575 , 518,852 ... , 384,242 , 9.8 Hospital Management ... , (18.3) Medical Insurance Administration Service Income , ... Medical Devices and Accessories Sales , 89,645 , ... 2,822 , 2,917 , (3.3) ...
Breaking Medicine Technology: