Navigation Links
Scientists show how brain tumors outsmart drugs
Date:1/19/2010

Researchers at the Ludwig Institute for Cancer Research (LICR) at the University of California, San Diego School of Medicine and Moores UCSD Cancer Center have shown one way in which gliomas, a deadly type of brain tumor, can evade drugs aimed at blocking a key cell signaling protein, epidermal growth factor receptor (EGFR),that is crucial for tumor growth. In a related finding, they also proved that a particular EGFR mutation is important not only to initiate the tumor, but for its continued growth or "maintenance" as well.

The findings, which appear during the week of January 18 in an online early edition of the Proceedings of the National Academy of Sciences, provide both new insights into the behavior of gliomas as well as potential new drug targets and treatment strategies.

"The results suggest that the expression of EGFR is required for tumors to keep growing, and we've shown for the first time that there are mechanisms that the tumor is using to circumvent the need for the receptor," said Frank Furnari, PhD, associate professor of medicine at the UCSD School of Medicine and associate investigator at the San Diego branch of the LICR, adding that other cancers may use similar tactics. "We need to find out more about the signaling pathways that brain tumors use to get around targeted therapeutics, such as those directed at EGFR."

In aggressive gliomas, extra copies of the EGFR gene are produced, and half of such tumors also carry an EGFR mutation, which ramps up tumor growth and portends a poor prognosis. Clinical trials of anti-EGFR agents have been disappointing; brain tumors may respond initially, but later become resistant to the drugs. To better understand why, Furnari, Webster Cavenee, PhD, professor of medicine and director of San Diego's LICR branch, and their group wanted to find out if the mutant EGFR was needed by tumors for their continued growth.

The team including postdoctoral fellows Akitake Mu
'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Weizmann Institute scientists reveal how tendons shape developing bones
2. Scripps Research scientists find cancer cells co-opt fat metabolism pathway to become more malignant
3. Neuroscientists at Case Western Reserve University store information in isolated brain tissue
4. Scientists Find Molecular Switch Related to Huntingtons
5. Stanford scientists identify protein that keeps stem cells poised for action
6. Scientists Spot Source of Hurdle to AIDS Vaccine
7. BioProcess International Launches a New and Improved Website for Biopharmaceutical Managers and Scientists
8. Scientists Link Molecule to Severe Swine Flu
9. Scientists use cell phone records to predict spread of malaria
10. Scientists uncover protective mechanism against liver cancer
11. UNC scientists coordinate study of link between insulin use and cancer in people with diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... Providenciales, Turks and Caicos Islands, BWI (PRWEB) May 02, ... has a new website! It is http://www.thevenetiangracebay.com ... resort itself, and it incorporates the stunning white and ... "According to a study of Google, sixty seven percent ... process. The study showed that smartphones were used ...
(Date:5/1/2015)... 2015 Jusuru International has been awarded ... repositioning of its flagship nutritional supplement, Liquid BioCell™ Life, ... new name, new logo, new packaging, new products, and ... designed to identify and promote programs that serve as ... “DSA congratulates Jusuru International for their outstanding accomplishments and ...
(Date:5/1/2015)... 2015 The Workgroup for Electronic ... on the use of health IT to create efficiencies ... resource to the United States Government Accountability Office (GAO) ... cards in Medicare. The report, “ Potential Uses of ... released to the public on Apr. 24, 2015 and ...
(Date:5/1/2015)... 01, 2015 It’s raining bills on Capitol ... proposals to expand federal support for telemedicine. , ... has been working with Congress,” said Jonathan Linkous, CEO of ... the nation is poised to embrace the use of telecommunications ... step in fulfilling ATA’s mission to improve quality, access, equity ...
(Date:5/1/2015)... KY (PRWEB) May 01, 2015 Ernst ... CEO, Dr. Joshua Rosenthal, Co-Founder & CSO, and Burak ... finalists for the EY Entrepreneur Of The Year® ... Ernst & Young is a global leader in ... to be one of the top audit companies ...
Breaking Medicine News(10 mins):Health News:Turks and Caicos Resort, The Venetian on Grace Bay, Launches New Web Presence 2Health News:Jusuru International Receives 2015 DSA Ethos Award 2Health News:Jusuru International Receives 2015 DSA Ethos Award 3Health News:Jusuru International Receives 2015 DSA Ethos Award 4Health News:Jusuru International Receives 2015 DSA Ethos Award 5Health News:WEDI Contributes to Newly Released U.S. Government Accountability Office (GAO) Study on Potential Use of Electronically Readable Medicare Cards 2Health News:WEDI Contributes to Newly Released U.S. Government Accountability Office (GAO) Study on Potential Use of Electronically Readable Medicare Cards 3Health News:ATA: Congress Floods the Halls with Telemedicine Proposals 2Health News:RowdMap, Inc. Named as a Ernst & Young Entrepreneur Of The Year® 2015 Award Finalist 2
... -- The worldwide incidence of cancer is expected to increase ... than 90 percent in the poorest nations, a new study ... cervical and stomach cancer) appear to be declining in some ... by substantial increases in the types of cancer associated with ...
... , THURSDAY, May 31 (HealthDay News) -- More than ... new government report shows. "Untreated tooth decay is ... Dye, an epidemiologist at the U.S. Centers for Disease ... appears that we haven,t been able to make any ...
... Four University of Houston (UH) students are well on their ... this spring in their work toward new therapies for prostate ... Center for Nuclear Receptors and Cell Signaling (CNRCS), these students ... and expressed, which is vital in developing treatments for cancer. ...
... Philadelphia National data show that currently more than ... obese, and an additional 10 percent are overweight. In ... School of Medicine at the University of Pennsylvania, in ... says that effective strategies to target pregnancy, infancy, and ...
... icon of cleanliness for home and commercial kitchens, restaurants, ... bacteria like other surfaces if not cleaned often. Scientists ... Langmuir , of a practical way to make stainless ... explain that while stainless steel is prized for its ...
... THURSDAY, May 31 (HealthDay News) -- When men are ... their future fertility than women, new Scottish research says. ... information provided to young women diagnosed with cancer and ... fertility expert," study co-author Valerie Peddie, a fertility nurse ...
Cached Medicine News:Health News:Worldwide Cancer Incidence Predicted to Rise 75% by 2030 2Health News:1 in 5 Americans Has Untreated Cavities: CDC 2Health News:Student researchers seek to develop new therapies for cancer 2Health News:Student researchers seek to develop new therapies for cancer 3Health News:Researchers call for obesity prevention efforts to focus on community-wide systems 2Health News:Men and Women With Cancer May Receive Different Fertility Information 2
(Date:5/1/2015)...  AcelRx Pharmaceuticals, Inc. (Nasdaq: ACRX ), a specialty ... innovative therapies for the treatment of acute and breakthrough ... chief financial officer  will be participating in three upcoming ... Mizuho Third Annual Healthcare Corporate Access Day ... New York Bank ...
(Date:4/30/2015)... April 30, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. ... with a focus on Omega-3 therapies for cardiovascular ... highlights and financial results for the fiscal year ... herein are in Canadian dollars unless otherwise stated. ... significant, with the right strategic partners and additional ...
(Date:4/30/2015)... April 30, 2015  Accuray Incorporated (Nasdaq: ... an agreement with MIM Software Inc. to further ... and CyberKnife ® product portfolios. The new ... technology. This is Accuray,s second collaboration with MIM; ... the first iPad-based treatment plan review capability, PlanTouch™. ...
Breaking Medicine Technology:AcelRx Pharmaceuticals to Participate at Upcoming Investor Conferences in May 2Pivotal Therapeutics Announces 2014 Financial Results 2Pivotal Therapeutics Announces 2014 Financial Results 3Pivotal Therapeutics Announces 2014 Financial Results 4Pivotal Therapeutics Announces 2014 Financial Results 5Pivotal Therapeutics Announces 2014 Financial Results 6Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 2Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 3
... COLD SPRING HARBOR, N.Y. , May 18 AccuVein ... Medipath Division of Morepen Laboratories to sell the AV300 vein finder in ... signed 30 distributors worldwide. , , ... AccuVein AV300 helps healthcare professionals locate veins for blood draw , ...
... , WINTER PARK, Fla. , May 18 ... cataract surgery and presbyopia, today announced that the company has received ... System for anterior capsulotomy during cataract surgery.   , ... The LensAR Laser System integrates ...
Cached Medicine Technology:AccuVein Signs Exclusive Distribution Agreement in India to Sell Vein Illumination Device 2AccuVein Signs Exclusive Distribution Agreement in India to Sell Vein Illumination Device 3LensAR Laser System(TM) Receives FDA Clearance for Use in Cataract Surgery 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: