Navigation Links
Scientists show how a neuron gets its shape
Date:4/3/2009

Ask a simple question, get a simple answer: When Abraham Lincoln was asked how long a man's legs should be, he absurdly replied, "Long enough to reach the ground." Now, by using a new microscopy technique to watch the growth of individual neurons in the microscopic roundworm Caenorhabditis elegans, Rockefeller University researchers are turning another deceptively simple question on its head. They asked, "How long should a worm's neurons be?" And the worms fired back, "Long enough to reach their targets."

The researchers' surprising result: Rather than growing like the branches of a tree extending outward certain neurons work backward from their destination, dropping anchor and stretching their dendrites behind them as they crawl away. The work, led by Shai Shaham, head of the Laboratory of Developmental Genetics, and Maxwell Heiman, a research associate in the lab, not only addresses an age-old question of how neurons get their shape, but is also changing the way scientists think about the genetic program that wires the brain and allows it to grow throughout development.

"When I came to the lab, I thought that you would build a brain just like you would a house," says Heiman. "The cell would measure the distance between its cell body and its target and then specify a dendrite of that length. Now, I'm not thinking about that kind of physical map at all. I think of a connectivity map, where what's programmed are these connections among neurons and between neurons and their anchoring points."

Since they were interested in how neurons get their shapes, Heiman and Shaham used a chemical to randomly mutate genes and then screened through thousands of animals for ones whose neurons were shaped abnormally. They specifically looked at a group of 12 sensory neurons whose dendritic tips converge at the worm's nose in a sensory organ called the amphid. These dendritic tips collect information from the outside environment and give the worm cues
'/>"/>

Contact: Thania Benios
tbenios@rockefeller.edu
212-327-7146
Rockefeller University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Neuroscientists demonstrate link between brainwave acticity and visual perception
2. Einstein scientists propose new theory of autism
3. International Scientists Secure Quality in Molecular Diagnostics
4. CSHL neuroscientists propose project to comprehensively map mammalian brain circuits
5. Scientists Identify More Breast Cancer Genes
6. Scientists Capture HIV Transfer Among T-Cells on Video
7. 2 NYU scientists named Howard Hughes Medical Institutes Early Career Scientists
8. Two NYU Scientists Named Howard Hughes Medical Institutes early career scientists
9. Three Johns Hopkins researchers named Howard Hughes Medical Institute early career scientists
10. Wayne State University Scientists ID New Biomarker for Prostate Cancer
11. URI scientists reveal mechanism that regulates cancer-causing gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2015)... “ ActOn ” was featured on NewsWatch as part of ... and coolest applications on the market for iOS, Android, and ... conducted the app review and shared with viewers how this ... a difference. , In this material world, almost everything is ... money, which is why those things should be prioritized above ...
(Date:5/2/2015)... May 02, 2015 We are pleased ... Delray Recovery Center as one of the Top Workplaces ... in the addiction treatment field for their ethics and ... innovate and to continue their educational efforts. The Delray ... environment, never forgetting their purpose – to help individuals ...
(Date:5/2/2015)... 02, 2015 Kare Visits LLC. launched in ... busy caregivers. Kare Visits offers relief for caregivers by ... facilities. According to the Caregiver Action Network, eight ... of 20 hours a week caring for an elderly or ... to hire a nurse, a caregiver is now empowered to ...
(Date:5/2/2015)... 02, 2015 With the success that Veatch ... proud to welcome Neida Miranda and Alex Shields to the ... has over 41 years of combined experience working with dentists ... the dental field for 8 years. She was certified ... Texas. Customer service, positive attitude and showing the importance of ...
(Date:5/1/2015)... 01, 2015 Pioneer Millworks, the largest ... latest in their reclaimed wood products at the 27th ... Javits Center in NYC this May. Their newest offerings, ... much anticipated texture and color to North America's platform ... of texture and color in the design world and ...
Breaking Medicine News(10 mins):Health News:An Application to Help People Make a Difference Was Featured on NewsWatch Television 2Health News:The Delray Recovery Center Named 2015 Top Workplace 2Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2Health News:Veatch Dental Consulting Services Welcomes New Team Members 2Health News:Intensely Textured Reclaimed Wood to be Unveiled at ICFF in NYC by Pioneer Millworks 2Health News:Intensely Textured Reclaimed Wood to be Unveiled at ICFF in NYC by Pioneer Millworks 3
... AstraZeneca (NYSE: AZN ) is aware ... (FDA) posted to its web site -- and subsequently ... Psychopharmacologic Drugs Advisory Committee (PDAC) meeting. The PDAC meeting ... provided in supplemental new drug applications (sNDA) for SEROQUEL ...
... to help men and women from the United Kingdom (UK) and Europe who ... has opened its London center. , ... (PRWEB) April 3, 2009 -- In its continued ... who are thinning and balding, Nu/Hart Hair Clinics , a world leader ...
... April 3 Recently, researchers at the University ... conducted a study of U.S. hospitals and discovered that ... year. The study recommended solutions, including location-based technology, to ... of this study come at a time when Versus ...
... WARSAW, Ind., April 3 Zimmer Holdings, Inc. (NYSE: ... 2009 sales and earnings conference call will be broadcast live ... a.m. Eastern Time. A news release detailing the quarterly ... of the conference call.The live audio webcast can be accessed ...
... radiation dose delivered to patients undergoing coronary CT ... using tube current modulation, according to a study ... PA. , The study included 172 patients ... tube current modulation and 95 patients who were ...
... Researchers from Boston University School of Medicine,s (BUSM) ... traits associated with healthy aging and longevity amongst ... in collaboration with scientists from the National Institute ... the Journal of the American Geriatrics Society ...
Cached Medicine News:Health News:FDA Advisory Committee Documents for SEROQUEL XR Available on AstraZeneca Web Site 2Health News:FDA Advisory Committee Documents for SEROQUEL XR Available on AstraZeneca Web Site 3Health News:FDA Advisory Committee Documents for SEROQUEL XR Available on AstraZeneca Web Site 4Health News:FDA Advisory Committee Documents for SEROQUEL XR Available on AstraZeneca Web Site 5Health News:Nu/Hart, World Leader in Hair Transplants, Opens London Centre 2Health News:Nu/Hart, World Leader in Hair Transplants, Opens London Centre 3Health News:Versus Technology to Showcase Leading Enterprise Patient and Clinical Workflow Solutions at HIMSS 2009 2Health News:Versus Technology to Showcase Leading Enterprise Patient and Clinical Workflow Solutions at HIMSS 2009 3Health News:Versus Technology to Showcase Leading Enterprise Patient and Clinical Workflow Solutions at HIMSS 2009 4Health News:Radiation dose can be reduced for 'triple rule-out' coronary CT angiography 2Health News:Researchers identify personality traits 2
(Date:5/1/2015)... Research and Markets ( http://www.researchandmarkets.com/research/pjbxjd/us_aco_it ) ... IT Spending Outlook 2018" report to their offering. ... covered by ACO would grow at a CAGR of ... IT spending has been studied on three main grounds ... on services. Our research provides current market estimation and ...
(Date:5/1/2015)... PRINCETON, N.J. , May 1, 2015 ... it has expanded its current therapeutic focus ... and other serious psychiatric disorders. Braeburn has ... atypical (or second-generation) antipsychotic risperidone for treatment ... risperidone acquisition Braeburn acquires global rights to ...
(Date:5/1/2015)... -- Semler Scientific, Inc. (Nasdaq: SMLR ), an ... markets products that assist healthcare providers in monitoring patients ... the first quarter ended March 31, 2015. ... continued progress with year over year growth of 44% ... said Doug Murphy-Chutorian , M.D., chief executive officer ...
Breaking Medicine Technology:United States ACO IT Spending Outlook 2014-2018 2Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 2Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 3Braeburn Pharmaceuticals expands pipeline to include two schizophrenia treatments 4Semler Reports First Quarter 2015 Financial Results 2Semler Reports First Quarter 2015 Financial Results 3Semler Reports First Quarter 2015 Financial Results 4Semler Reports First Quarter 2015 Financial Results 5
... Life Spine, a medical device company that designs, develops, ... spinal disorders, announced today amidst consolidations in the industry ... its history. As a full line spine company Life ... sacrum. Aileron™, a minimally invasive adjustable InterSpinous ...
... China, Nov. 4, 2011 /PRNewswire-Asia-FirstCall/ -- Mindray Medical International Limited ... marketer of medical devices worldwide, today announced that it will ... fair to be held between November 16 and 19 in ... H2 C07 at the 43rd World Forum of Medicine - ...
Cached Medicine Technology:Mindray Medical to Exhibit at MEDICA 2011 in Dusseldorf, Germany from November 16-19, 2011 2Mindray Medical to Exhibit at MEDICA 2011 in Dusseldorf, Germany from November 16-19, 2011 3
... low profile implantable bipolar fixed screw-in ... either the atrium or the ventricle. ... a screwdriver shape stylet which is ... ring tip and fixation screw are ...
... are implantable bipolar extendable/retractable screw-in permanent ... the atrium or the ventricle. The ... extended or retracted by turning the ... an anti-chattering mechanism for steady pacing ...
The Vitatron Pirouet S+ lead series are endocardial leads with extendable/retractable helical screw designed for reliable fixation and optimal pacing characteristics....
Used to occupy an empty hole which is not being used in an implantablepacemaker header....
Medicine Products: