Navigation Links
Scientists show how a neuron gets its shape
Date:4/3/2009

Ask a simple question, get a simple answer: When Abraham Lincoln was asked how long a man's legs should be, he absurdly replied, "Long enough to reach the ground." Now, by using a new microscopy technique to watch the growth of individual neurons in the microscopic roundworm Caenorhabditis elegans, Rockefeller University researchers are turning another deceptively simple question on its head. They asked, "How long should a worm's neurons be?" And the worms fired back, "Long enough to reach their targets."

The researchers' surprising result: Rather than growing like the branches of a tree extending outward certain neurons work backward from their destination, dropping anchor and stretching their dendrites behind them as they crawl away. The work, led by Shai Shaham, head of the Laboratory of Developmental Genetics, and Maxwell Heiman, a research associate in the lab, not only addresses an age-old question of how neurons get their shape, but is also changing the way scientists think about the genetic program that wires the brain and allows it to grow throughout development.

"When I came to the lab, I thought that you would build a brain just like you would a house," says Heiman. "The cell would measure the distance between its cell body and its target and then specify a dendrite of that length. Now, I'm not thinking about that kind of physical map at all. I think of a connectivity map, where what's programmed are these connections among neurons and between neurons and their anchoring points."

Since they were interested in how neurons get their shapes, Heiman and Shaham used a chemical to randomly mutate genes and then screened through thousands of animals for ones whose neurons were shaped abnormally. They specifically looked at a group of 12 sensory neurons whose dendritic tips converge at the worm's nose in a sensory organ called the amphid. These dendritic tips collect information from the outside environment and give the worm cues
'/>"/>

Contact: Thania Benios
tbenios@rockefeller.edu
212-327-7146
Rockefeller University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Neuroscientists demonstrate link between brainwave acticity and visual perception
2. Einstein scientists propose new theory of autism
3. International Scientists Secure Quality in Molecular Diagnostics
4. CSHL neuroscientists propose project to comprehensively map mammalian brain circuits
5. Scientists Identify More Breast Cancer Genes
6. Scientists Capture HIV Transfer Among T-Cells on Video
7. 2 NYU scientists named Howard Hughes Medical Institutes Early Career Scientists
8. Two NYU Scientists Named Howard Hughes Medical Institutes early career scientists
9. Three Johns Hopkins researchers named Howard Hughes Medical Institute early career scientists
10. Wayne State University Scientists ID New Biomarker for Prostate Cancer
11. URI scientists reveal mechanism that regulates cancer-causing gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... The Case Management Society of America ... CMSA Lifetime Achievement Award, to Anne Llewellyn RN-BC, MS, ... 25th at the association’s 25th Annual Conference and Expo ... The CMSA Board of Directors awards the Lifetime Achievement ... significant contribution to practice of case management and in ...
(Date:5/27/2015)... (PRWEB) May 27, 2015 This year, ... health awareness campaign and encouraging those affected to seek assistance ... Mental Health (NAMI), one in five children, ages 13 ... illness. Additionally, 50% of all cases of mental illness within ... suggesting, it is essential to seek help before reaching a ...
(Date:5/27/2015)... According to research conducted by Dr. Huay-Zong ... Dallas some migraine patients have an increased likelihood of ... apparently also have some shared risk factors -- particularly ... a history of diabetes and/or smoking. Both conditions were ... in particular was less common in Hispanics. , ...
(Date:5/26/2015)... 27, 2015 Avid Collector, Andrew ... search for original Jimi Hendrix January 11-23, 1969 psychedelic German ... "medusa" image of Hendrix for this concert poster ... is also known as the Hendrix with wired ... over twelve days. The tour started at the ...
(Date:5/26/2015)... 2015 Degeneration of the white matter ... specific types of Alzheimer’s disease (AD), including early-onset AD, ... the journal Radiology. , “Alzheimer’s is a gray ... the study conducted at the Neuroimaging Research Unit, San ... damage has a central role in how the disease ...
Breaking Medicine News(10 mins):Health News:CMSA to Present Prestigious Lifetime Achievement Award to Anne Llewellyn RN-BC, MS, BHSA, CCM, CRRN 2Health News:The Glenholme School Observes Mental Health Awareness Month 2Health News:The Glenholme School Observes Mental Health Awareness Month 3Health News:Santa Rosa Orthopaedics Offers Insights into Recent Study Results Connecting Migraines with Chronic Conditions Such as Carpal Tunnel Syndrome 2Health News:Santa Rosa Orthopaedics Offers Insights into Recent Study Results Connecting Migraines with Chronic Conditions Such as Carpal Tunnel Syndrome 3Health News:Santa Rosa Orthopaedics Offers Insights into Recent Study Results Connecting Migraines with Chronic Conditions Such as Carpal Tunnel Syndrome 4Health News:Avid Collector from Vintage Rock Posters Announces His Search for Original Jimi Hendrix January 11-23, 1969 Psychedelic German Concert Tour Posters 2Health News:RSNA: Imaging Test May Identify Biomarker of Alzheimer’s Disease 2Health News:RSNA: Imaging Test May Identify Biomarker of Alzheimer’s Disease 3
... Mo. Young adults between the ages of 18 and ... according to the National Survey on Drug Use & Health. ... rural adolescents who engage in prosocial behaviors, such as volunteering ... young adults. Gustavo Carlo, Millsap Professor of Diversity in ...
... -- Men are less likely to drink, use tobacco or ... study. It included more than 200 at-risk males who ... studies have found that marriage can reduce men,s negative behavior, ... This study found that fatherhood was independently associated with ...
... about painful jaw problems that plague millions of Americans are ... results, from the first large-scale clinical study of its kind, ... as TMD. The findings, published in the November ... to new methods of diagnosing facial pain conditions, predicting who ...
... HOUSTON - When given alongside radiation therapy for head ... time to reduce the debilitating side effect of xerostomia, ... MD Anderson Cancer Center and Fudan University Shanghai Cancer ... Cancer , reported findings from the first randomized controlled ...
... that people who develop jaw pain disorders exhibit specific ... and noises in the jaw, more headaches and generally ... UB School of Dental Medicine researchers who are international ... have developed through international collaborations many of the most ...
... how the sense of smell changes as people age, found ... an unexpected response to odor that made it more difficult ... dangerous chemicals and poor nutrition. "We found ... those 60 and up," said Professor Diego Restrepo, Ph.D., director ...
Cached Medicine News:Health News:Volunteering, helping others decreases substance use in rural teens, MU study finds 2Health News:Fatherhood May Help Tough Guys Straighten Out 2Health News:Large-scale jaw pain study sheds light on pain disorders 2Health News:UT MD Anderson study finds acupuncture can prevent radiation-induced chronic dry mouth 2Health News:UT MD Anderson study finds acupuncture can prevent radiation-induced chronic dry mouth 3Health News:First large-scale study of pain reveals risk factors 2Health News:First large-scale study of pain reveals risk factors 3Health News:Researcher finds elderly lose ability to distinguish between odors 2
(Date:5/27/2015)... May 27, 2015 ... senkt die Leistungsfähigkeit enorm. Es ist schwierig konzentriert ... wacht zum falschen Zeitpunkt in einem Hotelzimmer auf, ... später, nach Hause zurückgekehrt, fühlt man sich  oft ... oder dem Partner etwas zu unternehmen oder bei ...
(Date:5/26/2015)... , May 26, 2015  The National Association of ... pleased to announce that general availability for the .pharmacy ... pharmacies and pharmacy-related entities may apply for .pharmacy domain ... launched in 2014, and NABP has approved more than ... prior limited registration periods. NABP created the .pharmacy TLD ...
(Date:5/26/2015)... Mass. , May 26, 2015  Haemonetics Corporation ... Gould , Vice President, Investor Relations, will present at ... Boston on June 4 th , 2015 ... may access Mr. Gould,s presentation live via webcast at: ... Haemonetics (NYSE: HAE ) is a global healthcare ...
Breaking Medicine Technology:Jetlag schneller überwinden! Spitzen-Athleten wissen wie: Doppelt so schnell voll leistungsfähig sein mit innovativer Technik 2Jetlag schneller überwinden! Spitzen-Athleten wissen wie: Doppelt so schnell voll leistungsfähig sein mit innovativer Technik 3Jetlag schneller überwinden! Spitzen-Athleten wissen wie: Doppelt so schnell voll leistungsfähig sein mit innovativer Technik 4General Availability for .Pharmacy Domain Names Begins June 3, 2015 2
... Pharmatek Laboratories, Inc., a premier contract development and ... it has added spray drying to its drug ... a Buchi B-290 Mini Spray Dryer for formulation ... can be used for both oral and parenteral ...
... April 25, 2011 Stereotaxis, Inc. (NASDAQ: STXS ... following investor conferences during May 2011: The ... Kaminski, President and Chief Executive Officer of Stereotaxis, is scheduled ... 3, 2011 at 4:10 p.m. ET. The JMP Securities ...
Cached Medicine Technology:Pharmatek Laboratories Adds Spray Drying to Drug Development Services 2Stereotaxis to Present at Upcoming Investor Conferences 2Stereotaxis to Present at Upcoming Investor Conferences 3
... infectious disease ELISA products make us a ... protocols for faster integration into the busy ... increased reliability and run-to-run consistency. Our Infectious ... for a wide range of serological assays ...
... disease ELISA products make us a leader ... for faster integration into the busy laboratory, ... reliability and run-to-run consistency. Our Infectious Disease ... a wide range of serological assays including ...
... of infectious disease ELISA products make us ... assay protocols for faster integration into the ... provide increased reliability and run-to-run consistency. Our ... assays for a wide range of serological ...
... infectious disease ELISA products make us a ... protocols for faster integration into the busy ... increased reliability and run-to-run consistency. Our Infectious ... for a wide range of serological assays ...
Medicine Products: