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Scientists shine new light on inflammatory diseases
Date:3/16/2008

>The researchers say that these findings could lead scientists to ways of preventing the bone destruction that is associated with some diseases. There is the potential to control inflammation and also to control bone destruction. This interferon response is very effective at preventing the destruction of bones, which is one of the major issues with rheumatoid arthritis, said Dr. Ivashkiv. So, what it does is sets up the next series of studies, in animal models, to try to determine whether this induction of interferon is beneficial or not.

The new research could also help explain how a patient involved in a University of Pennsylvania gene therapy experiment that used an adenovirus to deliver the gene died. Host response to adenoviral vectors is dependant on both IRF1 and TNF.

What we have described is that TNF has both pathogenic affectsit helps to sustain some of these inflammatory chemokines, but it also has a potential protective effect, because some of these interferon responses limit the amount of cell proliferation and they can also help to limit inflammation.


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Contact: Phyllis Fisher
fisherp@hss.edu
212-606-1197
Hospital for Special Surgery
Source:Eurekalert

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