Navigation Links
Scientists shed new light on walking
Date:1/22/2010

Researchers at the medical university Karolinska Institutet have created a genetically modified mouse in which certain neurons can be activated by blue light. Shining blue light on brainstems or spinal cords isolated from these mice produces walking-like motor activity. The findings, which are published in the scientific journal Nature Neuroscience, are of potential significance to the recovery of walking after spinal cord injury.

"This new mouse model will impact the way in which future studies examining the organization of neurons involved in walking are performed. We hope that our findings can provide insight that eventually will contribute to treatments for spinal cord injured patients", says Professor Ole Kiehn, who lead the study.

Excitatory neurons have been suggested to play an important role for the initiation and maintenance of locomotion, or walking. However, this has not been demonstrated directly. In order to test the hypothesis that activation of excitatory neurons is essential to locomotion, a research team at the Department of Neuroscience, Karolinska Institutet, created a genetically modified mouse which expresses a light sensitive protein in excitatory neurons.

The light sensitive protein, Channelrhodopsin2 (ChR2), is normally found in algae and activates the cell it is expressed in when exposed to blue light. ChR2 has previously been introduced into rodent cells by viral infection, but this can be problematic due to exposure and replication demands. The researchers circumvented the problems by creating the first genetically modified mouse to successfully express ChR2 in a specific set of neurons.

By inserting ChR2 into nerve cells expressing Vglut2 a transporter found in most excitatory neurons in the brainstem and spinal cord as well as many excitatory neurons in other regions of the brain they created a Vglut2-ChR2 mouse . The reason for doing this was to be able to selectively activate excit
'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... December 21, 2014 The Oncology Institute of ... the Santa Ana and Whittier offices. The Hope for the ... lives of patients and their families during the holiday season. ... to approximately 70 children between both offices. This event continues ... of Target’s community service team, store managers and assistant managers ...
(Date:12/20/2014)... a distinguished special dress supplier, has just done something ... cut prices to all its prom dresses already, offering ... Many of the hottest styles are sold here like ... more. , A spokesman for MissyDress says, “The great ... prom dresses or sweetheart chiffon prom dresses, you will ...
(Date:12/20/2014)... York, NY (PRWEB) December 20, 2014 ... that allege a metal-on-metal version of the artificial ... forward in state and federal courts, Bernstein Liebhard ... New Jersey’ Bergen County Superior Court on December ... permitted to begin deposition of plaintiffs on November ...
(Date:12/20/2014)... (PRWEB) December 20, 2014 The Doctor’s Office ... for the better part of a decade. They’ve treated ... a better, faster healthcare alternative to the Paramus ... announce three new additions to their staff of top-notch board ... Jill Zeiger MD. These new doctors will work ...
(Date:12/20/2014)... (PRWEB) December 20, 2014 The aftermath of ... quite a stir, not only in Hollywood, but worldwide. ... 18th , the ripples of that attack are starting a ... jobs at risk. But they are not the only ... could be in for some embarrassing times ahead, agents and ...
Breaking Medicine News(10 mins):Health News:MissyDress: The Prices of Prom Dresses Just Reduced 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 3Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 4Health News:The Doctor's Office Urgent Care Adds 3 New Physicians to Their Growing Medical Team 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 3Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 5
... doctor was acquitted on Wednesday of murdering three of his ... Martin, 71, a retired army officer from North Wales, was ... the lives of three seriously ill men, after a six-week ... look into the deaths of other patients under the care ...
... the first to visualize a need for laboratories in the Mexican ... Sustainability Laboratory (BNSL), which extends over an area of 4000 square ... security force and deal with terrorism // with the help ... for the lab come from USA, State of New Mexico and ...
... Barry D. Weiss, professor of family and community medicine and ... among patients. // ,They developed a tool which is ... minute questionnaire with six questions based on an ice cream ... by the patient their health literacy can be calculated. ...
... Gabriella gobbi and his team from Universite de ... increases the level of endocannabinoids by blocking the ... are chemicals present in brain which is responsible ... brain receptors are triggered during exercises and other ...
... Internal Medicine this week have found that the standard ... kidney failure is useless. //The study conducted by researchers ... found that a treatment called "plasma exchange" in patients ... means that the money which is currently spent in ...
... study conducted by the University of Alberta has revealed that ... mental health before its parents divorce. //The study does not ... More attention should be paid to the child while the ... the event has already occurred, according to Dr. Lisa Strohschein. ...
Cached Medicine News:Health News:British Doctor cleared of murder 2
(Date:12/19/2014)... , Dec. 18, 2014   Aratana Therapeutics, ... biopharmaceutical company focused on the licensing, development and ... announced positive results from its pivotal field study ... treating pain in dogs with osteoarthritis.  In the ... assessment scores that were statistically significant compared to ...
(Date:12/17/2014)... and SAN DIEGO , Dec. 17, 2014 ... ; AEX: PHIA) and Volcano Corporation (NASDAQ: VOLC ... for cardiovascular applications, today announced that they have entered into ... commence a tender offer to acquire all of the issued ... or a total equity purchase price of USD 1 billion ...
(Date:12/17/2014)... 17, 2014  Strategic Health Services, Inc. (SHS), a ... announced a strategic agreement with QualCare, Inc., a leading provider ... regional marketplace.  This agreement will further QualCare,s ... wellness solutions QualCare brings to its clients in ... QualCare plans cover more than 800,000 ...
Breaking Medicine Technology:Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 2Philips to acquire Volcano to expand global leadership position in image-guided therapy market 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 4Philips to acquire Volcano to expand global leadership position in image-guided therapy market 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 6Philips to acquire Volcano to expand global leadership position in image-guided therapy market 7Philips to acquire Volcano to expand global leadership position in image-guided therapy market 8Strategic Health Services to collaborate with QualCare on Population Health and Wellness Technology for QualCare Members 2Strategic Health Services to collaborate with QualCare on Population Health and Wellness Technology for QualCare Members 3
... Reportlinker.com announces that a new market research ... Pharmaceutical Packaging Industry - 2011 ... Pharmaceutical Packaging Industry - 2011 ... GBI Research, the leading business intelligence ...
... China, Nov. 28, 2011 /PRNewswire-Asia-FirstCall/ -- China Nepstar Chain ... the "Company"), the largest retail drugstore chain in China ... announced its unaudited financial results for the third quarter ... HighlightsFor the quarter ended September 30, 2011: ...
Cached Medicine Technology:Pharmaceutical Packaging Industry - 2011 Yearbook 2Pharmaceutical Packaging Industry - 2011 Yearbook 3Pharmaceutical Packaging Industry - 2011 Yearbook 4Pharmaceutical Packaging Industry - 2011 Yearbook 5Pharmaceutical Packaging Industry - 2011 Yearbook 6Pharmaceutical Packaging Industry - 2011 Yearbook 7Pharmaceutical Packaging Industry - 2011 Yearbook 8Pharmaceutical Packaging Industry - 2011 Yearbook 9China Nepstar Chain Drugstore Reports Third Quarter 2011 Financial Results 2China Nepstar Chain Drugstore Reports Third Quarter 2011 Financial Results 3China Nepstar Chain Drugstore Reports Third Quarter 2011 Financial Results 4China Nepstar Chain Drugstore Reports Third Quarter 2011 Financial Results 5China Nepstar Chain Drugstore Reports Third Quarter 2011 Financial Results 6China Nepstar Chain Drugstore Reports Third Quarter 2011 Financial Results 7China Nepstar Chain Drugstore Reports Third Quarter 2011 Financial Results 8China Nepstar Chain Drugstore Reports Third Quarter 2011 Financial Results 9
Slightly curved blunt dissector, double-ended. Length 11 1/2" (272 mm)...
Leroy-Raney scalp clips, sterile, disposable, plastic, ten clips/package....
Disposable scalp clip applier, comes loaded with 12 Leroy-Raney clips, ergonomic, easy to handle and position the clip....
... of comminution, aspiration and irrigation ... ultra-sonic energy. Allows for preservative ... particular, parenchymatous organs, offering the ... non-traumatic preparation with a low ...
Medicine Products: