Navigation Links
Scientists shed light on long-distance signaling in developing neurons
Date:2/19/2008

e it, you can survive.' In these rarer cases, the neuron lives to become part of the nervous system."

But how does this critical information get passed from the growth cone at the tip of the axon back to the cell's "command center," the nucleus?

"That was the central mystery we sought to clear up in this work," Dr. Jaffrey says.

To do so, his team examined axonal growth cones for messenger RNA (mRNA) -- bits of genetic material that help produce specific proteins. The team used an innovative new technique developed by study lead author Dr. Llewellyn J. Cox, a postdoctoral researcher in Dr. Jaffrey's lab. He coaxed axons to grow in such a way that the scientists were able to sample mRNA in the growth cones alone.

"By doing so, we were able to build a library of mRNA found in those growth cones," Dr. Cox said.

The experiment yielded one big surprise: a type of mRNA that produces a transcription factor called CREB.

"Prior research elsewhere has shown that CREB is essential to neuronal survival," Dr. Jaffrey says. "But no one had ever thought it might be active in the axon."

The team next used cutting-edge fluorescent technology to track CREB's activity in the presence of the "survival signal," NGF.

"We watched CREB being produced in the growth cone and then saw it travel back to the nucleus," Dr. Jaffrey says. "This was astounding -- it suggested that the axonally-synthesized protein could have a role in the nucleus, a very long distance away."

It is this axonally produced CREB that appears to be key to switching off the neuron's self-destruct mechanism, he says. "The axonal CREB enters the nucleus, where it induces gene expression that ensures that the developing neuron will survive," Dr. Jaffrey says.

This was confirmed in a later experiment where the team selectively abolished CREB mRNA from the axons but not the rest of the neuron. "When that happened, the neurons died,
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... one worrisome phenomenon is when an illness that originated in ... as zoonosis -- is not uncommon and keeps researchers on ... disease might make inroads into the human population. A ... the culprits in this case were guinea pigs. More specifically, ...
(Date:12/17/2014)... HealthDay Reporter TUESDAY, Dec. 16, ... approaching, a new study reveals that states that routinely perform ... drivers on their roads. The finding suggests that states ... to deter inebriated revelers from getting behind the wheel in ... passed regarding drinking and driving," said study lead author James ...
(Date:12/15/2014)... 15, 2014 Cancer researchers have just ... genetic causes of deadly malignant pleural mesothelioma. Surviving Mesothelioma ... their website. Click here to read it now. ... Hawaii Cancer Center, and New York’s Langone Medical Center ... mesothelioma patients in an effort to pinpoint the ...
(Date:12/15/2014)... a leading mobile app development company , custom ... which allows users to keep track of wines they ... right wine. At the center of WineMatch is ... wine information. All this information is assembled to help ... are close counterparts to one another are called Matches. ...
(Date:12/15/2014)... Expert pilots process visual information more efficiently than less ... during landings, a new study shows. Landing is ... master, and 36 percent of all airplane crashes and ... and landing. Researchers monitored the brain activity of ... they were at the controls of a flight simulator. ...
Breaking Medicine News(10 mins):Health News:Guinea Pigs Can Be Source of Serious Strep Infection 2Health News:Guinea Pigs Can Be Source of Serious Strep Infection 3Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 2Health News:Enforcement of Drunk Driving Laws Makes Roads Safer, Study Finds 3Health News:New Study Reveals Genetic Mutations That May Trigger Mesothelioma, According to Surviving Mesothelioma 2Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2Health News:Study Shows Why Expert Pilots Are Experts 2
... Center have found a new technique that employs RNA, a ... lead to therapeutics// for conditions in which nudging a gene ... with a novel research tool to investigate the role that ... paper appearing online at Nature Chemical Biology and in an ...
... right type of fat may actually keep child obesity at ... unsaturated fat and very little omega-3. ,A study ... was undertaken by scientists at Goteborg University. These children belong ... revealed that 23% of the children belong to an overweight ...
... MPs, members of the Committee of Public Accounts, has come out ... ,Levels of obesity in children aged two to 10 years ... 2004, according to the Health Survey for England. , ... as obese. ,The Public Accounts Committee report ...
... Boston ranked the top city in America for having a ... conducted by Fit Pregnancy magazine, Boston’s outstanding// healthcare resources is ... like low birth risks and family recreation. The magazine shared ... Wednesday. ,Mayor Thomas M. Menino, while commenting on ...
... study finds that CT scans used in emergency rooms spotted ... MRI scans which are better in identifying any type of ... to magnetic resonance imaging,” wrote Dr. Geoffrey A. Donnan and ... note accompanying the study report. ,Doctors argue that ...
... project to revamp its healthcare infrastructure and train health ... expected to benefit over 45 million people. ,Health ... medical facilities at the village level and the project ... scheme would benefit over 45 million people at the ...
Cached Medicine News:Health News:A Novel Technique Nudges Genes Into Activity 2Health News:A Novel Technique Nudges Genes Into Activity 3Health News:Under-Elevens Hurtle Towards Obesity, British MPs Call for Action 2Health News:Mega Project to Revamp Karnataka’s Healthcar 2
(Date:12/17/2014)... ANGELES , Dec. 17, 2014  ImmunoCellular ... the US Patent and Trademark Office (USPTO) has ... ICT-107, a dendritic cell-based immunotherapeutic vaccine targeting six ... The claims of US Patent No. 8,871,211, which ... neural cancer by administering a dendritic cell composition ...
(Date:12/17/2014)... PCCA received the Autism Hope Alliance,s ... program seal for best practices in meeting needs ... practices, materials and goods that meet strict criteria ... affected by autism often have unique physical or ... found in food and medicine – for instance ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research and ... addition of the "Inferior Vena Cava (IVC) Filters ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... sector is projected to reach US$435 million by 2016. ... nearly 39% (2015) of the global value while ...
Breaking Medicine Technology:ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 4
... March 2, 2011 A new ad campaign ... 2445 would raise taxes on prescription drug benefits and ... reduce health care costs for Mississippi families and businesses, ... S.B. 2445 would also put the State Board ...
... has launched a groundbreaking initiative for primary care physicians ... Health Group, Inc., is providing qualifying primary care practices ... extract usefulness out of existing clinical data at the ... practice improvement support and education. The initiative is supported ...
Cached Medicine Technology:New Ad Campaign: Secret Provision Raises Taxes on Prescription Drug Benefits, Creates 'Conflict of Interest' 2Joslin Diabetes Center Launches Initiative to Resolve the Critical Link Connecting Continuing Medical Education (CME) to Sustained Quality Improvement 2Joslin Diabetes Center Launches Initiative to Resolve the Critical Link Connecting Continuing Medical Education (CME) to Sustained Quality Improvement 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: