Navigation Links
Scientists see Norwalk virus' Achilles heel
Date:3/18/2008

Using the Canadian Light Source synchrotron, an international team led by University of Calgary researcher Ken Ng has determined the detailed structure of the enzyme the Norwalk virus uses to make copies of its genetic code in order to replicate itself. The information is crucial to developing drugs that could be used to treat outbreaks of Norwalk and other related viruses.

The Norwalk virus uses the enzyme, RNA polymerase, to make new strands of RNA using an existing RNA strand as a template. The copying, which occurs within an area of the enzyme called an active site, can be blockedor inhibited--with a drug molecule shaped to fit the site, like a key in a key hole.

These are the first structures showing the enzyme doing its job interacting with RNA, says Professor Ng. These structures provide ideas of how we could develop new antiviral drugs that block the enzymes activity.

The group includes scientists from the University of Calgary, University of Oviedo (Spain), Penn State University, the University of Kansas and the Canadian Light Source. Their work appears in the March 21 issue of the Journal of Biological Chemistry.

Outbreaks of Norwalk virus are notorious for the havoc they can cause to people living in close quarters, from cruise ships to hospital wards, often causing severe dehydration due to vomiting and diarrhea. The currently untreatable bug belongs to a superfamily of viruses that stores their genetic code as RNA, including polio, hepatitis C, foot-and-mouth disease and even the common cold. The problem with all of these viruses is the lack of effective treatments.

The best doctors can do with Norwalk patients is treat the symptoms. We have the polio vaccine, but many other serious diseases, like hepatitis C, lack effective treatments, explains Professor Ng. This polymerase is closely related in all of these viruses, so an inhibitor drug that works against Norwalk virus could also work in treating hepatitis C.


'/>"/>

Contact: Matthew Dalzell
matthew.dalzell@lightsource.ca
306-657-3739
Canadian Light Source, Inc.
Source:Eurekalert

Related medicine news :

1. 52 minority scientists receive travel fellowships to Experimental Biology 2008
2. IUPUI scientists report first 3-D view of anti-cancer agent
3. Scientists successfully awaken sleeping stem cells
4. Bonn scientists discover new hemoglobin type
5. Scientists shine new light on inflammatory diseases
6. Scientists identify new leads for treating parasitic worm disease
7. Scientists say tropics are next emerging disease hotspot
8. Novel discovery by Einstein scientists could lead to much-needed kidney failure treatment
9. Scientists Spot Biochemical Sign of Depression
10. Scientists determine structure of brain receptor implicated in epilepsy and PMT
11. Scientists Engineer Protein That Could Battle Strep
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... Austin ... of the American College of Mohs Surgery and to Dr. Russell Peckham for medical ... and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dublin - ... " Global Markets for Spectroscopy Equipment" report ... This report focuses on the global market of ... applications in various applications. The report deals with spectroscopy ... industries: pharmaceutical and biotechnology, food and beverage, and environmental ...
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
Breaking Medicine Technology: