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Scientists rewrite rulebook on breast cancer in landmark global study
Date:4/18/2012

thways networks that control cell growth and division. This could pinpoint how these gene faults cause cancer, by disrupting important cell processes.

This is the second major breakthrough announced by BC Cancer Agency scientists in as many weeks. On April 4, a team led by Dr. Sam Aparicio celebrated the decoding of the genetic makeup of the most-deadly of breast cancers, triple-negative breast cancer, which until then was defined by what it was missing, not what it was. Similar to that announcement, today's new discovery identifies genes that were previously unknown to be linked to breast cancer and makes it clear that breast cancer is an umbrella term for what really is a number of unique diseases.

While the research is unlikely to benefit women who currently have breast cancer, it substantially advances how scientists approach further research and clinical trials by providing them with a springboard to develop new treatment options and drugs targeted to specific genes.

The research was carried out in collaboration with the following institutes:

  • British Columbia Cancer Agency, Vancouver
  • University of British Columbia, Vancouver
  • Department of Oncology, University of Cambridge
  • Department of Applied Mathematics and Theoretical Physics, University of Cambridge
  • Department of Genetics, The Institute for Cancer Research
  • Oslo University Hospital
  • Department of Histopathology, University of Nottingham
  • Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre
  • King's College London, Breakthrough Breast Cancer Research Unit
  • Manitoba Institute of Cell Biology, University of Manitoba
  • NIHR Comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London
  • Institute for Clinical Medicine, Faculty of Medicine, University of Oslo
  • Cambridge Experimenta
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Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

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