Navigation Links
Scientists rewrite rulebook on breast cancer in landmark global study
Date:4/18/2012

Scientists at the BC Cancer Agency and University of British Columbia have identified new breast cancer genes that could change the way the disease is diagnosed and form the basis of next-generation treatments.

Researchers have reclassified the disease into 10 completely new categories based on the genetic fingerprint of a tumour. Many of these genes could offer much-needed insight into breast cancer biology, allowing doctors to predict whether a tumour will respond to a particular treatment. Whether the tumour is likely to spread to other parts of the body or if it is likely to return following treatment.

The study, published online today in the international journal Nature*, is the largest global study of breast cancer tissue ever performed and the culmination of decades of research into the disease.

In the future, this information could be used by doctors to better tailor treatment to the individual patient.

The team at the BC Cancer Agency, in collaboration with Cancer Research UK's Cambridge Research Institute and Manitoba Institute of Cell Biology at University of Manitoba, analyzed the DNA and RNA of 2,000 tumour samples taken from women diagnosed with breast cancer between five and 10 years ago. The sheer number of tumours mapped allowed researchers to spot new patterns in the data.

Study milestones include:

  • Classified breast cancer into 10 subtypes grouped by common genetic features, which correlate with survival. This new classification could change the way drugs are tailored to treat women with breast cancer.

  • Discovered several completely new genes that had never before been linked to breast cancer. These genes that drive the disease are all targets for new drugs that may be developed. This information will be available to scientists worldwide to boost drug discovery and development.

  • Revealed the relationship between these genes and known cell signaling pathways networks that control cell growth and division. This could pinpoint how these gene faults cause cancer, by disrupting important cell processes.

This is the second major breakthrough announced by BC Cancer Agency scientists in as many weeks. On April 4, a team led by Dr. Sam Aparicio celebrated the decoding of the genetic makeup of the most-deadly of breast cancers, triple-negative breast cancer, which until then was defined by what it was missing, not what it was. Similar to that announcement, today's new discovery identifies genes that were previously unknown to be linked to breast cancer and makes it clear that breast cancer is an umbrella term for what really is a number of unique diseases.

While the research is unlikely to benefit women who currently have breast cancer, it substantially advances how scientists approach further research and clinical trials by providing them with a springboard to develop new treatment options and drugs targeted to specific genes.

The research was carried out in collaboration with the following institutes:

  • British Columbia Cancer Agency, Vancouver
  • University of British Columbia, Vancouver
  • Department of Oncology, University of Cambridge
  • Department of Applied Mathematics and Theoretical Physics, University of Cambridge
  • Department of Genetics, The Institute for Cancer Research
  • Oslo University Hospital
  • Department of Histopathology, University of Nottingham
  • Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre
  • King's College London, Breakthrough Breast Cancer Research Unit
  • Manitoba Institute of Cell Biology, University of Manitoba
  • NIHR Comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London
  • Institute for Clinical Medicine, Faculty of Medicine, University of Oslo
  • Cambridge Experimental Cancer Medicine Centre.


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Related medicine news :

1. Scientists tailor cell surface targeting system to hit organelle ZIP codes
2. Scientists identify major source of cells defense against oxidative stress
3. Scientists uncover multiple faces of deadly breast cancer
4. Scientists solving the mystery of human consciousness
5. A*STAR scientists discover special class of natural fats stimulates immune cells to fight diseases
6. Hutchinson Center and TGen scientists discover potential break through in pancreatic cancer
7. Scientists study link between amyloid beta peptide levels and Alzheimers disease
8. Scientists measure how energy is spent in martial arts
9. Scientists link 2 cancer-promoting pathways in esophageal cancer
10. Hutchinson Center scientists break through pancreas cancer treatment barrier
11. Sanford-Burnham scientists unravel cancer drugs secret to resistance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/11/2019)... ... September 11, 2019 , ... Ahipoki is excited to announce a new vegan ... to vegans, vegetarians, pescatarians and poke bowl fans alike. Ahimi is made of ... its meaty texture similar to tuna, Ahipoki customers will now have a ...
(Date:9/11/2019)... ... September 10, 2019 , ... Women’s Excellence is excited to announce ... at 32686 Woodward Ave, Suite 103, Royal Oak, MI 48073 in the heart of ... offers comprehensive women’s health services in a contemporary, spa-like atmosphere. We are thrilled ...
(Date:9/11/2019)... ... September 10, 2019 , ... Four Shriners for ... physicians have been recognized among the best doctors in the San Gabriel Valley ... Robert H. Cho, M.D. – Chief of Staff, scoliosis, spinal deformity ...
(Date:9/11/2019)... (PRWEB) , ... September 10, 2019 , ... ... provide critical support to the most vulnerable communities impacted by Hurricane Dorian. ... in South Carolina, the Episcopal Diocese of Georgia, and the Episcopal Farmworker Ministry, ...
(Date:9/9/2019)... HERNDON, Va. (PRWEB) , ... September 09, 2019 ... ... North America, today announced that IP Access International will integrate the iDirect iQ ... terminal, a portable and hybrid communications solution for first responders. The iQ 200 ...
Breaking Medicine News(10 mins):
(Date:9/14/2019)... ... September 13, 2019 , ... ... in Montreal provided a plethora of breakthrough research studies including several cancer ... to detect breast cancer, response prediction of cancer immunotherapies and whole body, ...
(Date:9/14/2019)... ... 2019 , ... CME4Life, a leading provider of physician assistant ... at a world record “Longest Medical Lecture” on November 16, 2019. The lecture ... CME credits in 30 consecutive hours. ?The conference will take place at The ...
(Date:9/11/2019)... ... September 12, 2019 , ... Understanding the Drug Supply ... Webinar, Thursday, Sept. 26, 2019, 1:30-3:00 p.m. EDT, https://www.fdanews.com/understanding-the-dscsa , Need ... the company clear on nuances of the guidelines regulating the drug supply chain? ...
Breaking Medicine Technology: