Navigation Links
Scientists reveal new insights into tendon injury
Date:3/1/2011

Scientists have discovered how tendons the fibrous tissue that connects muscle to bone become damaged through injury or the ageing process in what could lead to new treatments for people with tendon problems.

The University of Manchester team, working with colleagues at Glasgow University, have been investigating 'adhesions', which are a build up of unwanted fibrous tissue on internal organs that have been damaged as a result of surgery or injury.

Adhesions cause organs to stick together and are extremely painful and distressing for patients, who often have to undergo surgery and rehabilitation. The estimated cost of adhesions to the NHS is 100 million each year.

In this study, published in the journal PLoS One, the researchers wanted to understand how tendon adhesions form, so examined the surface of healthy tendons and discovered that they are covered by a thin layer of skin.

"Tendons attach our muscles to bone and are essential for movement," said lead researcher Professor Karl Kadler, from the Wellcome Trust Centre for Cell Matrix Research in Manchester's Faculty of Life Sciences.

"In order to do this, tendons need to glide freely but when an adhesion forms the tendon can no longer travel over the bone, which causes pain, stiffness and reduced movement.

"We reasoned that the surface of tendons must contain a special cell that stops adhesions from forming in healthy people. We discovered that the tendon is actually covered by a thin layer of epithelial cells, which are usually found in skin.

"Undamaged tendons do not form adhesions but when the tendon 'skin' is damaged, the cells inside the tendon form an unwanted adhesion which begins to stick to nearby tissues."

The team were able to show that mice with defective cells at the surface of their tendons appeared to have difficulty walking and spontaneously develop tendon adhesions, even without surgery or injury.

Dr Susa
'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... 28, 2014 An inventor and dental assistant ... a patient’s filling and it was almost impossible to reach. ... light," she said. , The patent-pending Access Light allows for ... to areas of the mouth, as well as avoids harm ... safety. Easy to use and clean, it also helps prevent ...
(Date:11/28/2014)... Hamilton, ON Canada (PRWEB) November 28, 2014 ... labels for the stuff kids lose® and an award-winning ... Julie Cole, Julie Ellis, Cynthia Esp, and Tricia Mumby ... Entrepreneur Award. They were recognized with the PROFIT Award ... Cole, Julie Ellis, Cynthia Esp, and Tricia Mumby) accepted ...
(Date:11/28/2014)... A newly released article from Community ... influenza virus that will soon be spreading across the United ... begins with a brief explanation of what the influenza virus ... that children under the age of 5, adults over the ... as heart and lung diseases, asthma, or diabetes, are at ...
(Date:11/28/2014)... Miami, FL (PRWEB) November 28, 2014 Lice ... service areas of its in-home head lice service for ... location in the center of Coral Gables on Pone De-leon ... in Bay Harbor Islands that service Miami-Dade & Broward. ... physical salon in South Florida which has been treating families ...
(Date:11/28/2014)... 28, 2014 "Most of my life, I ... use crutches," said an inventor from Findlay, Ohio. "I thought ... to support my foot, which inspired me to invent this ... a convenient way to support an injured foot. The sling ... eliminates the need for crutches. The design redistributes weight so ...
Breaking Medicine News(10 mins):Health News:Mabel's Labels’ Co-Founders Named A Winner In The 2014 RBC Canadian Women Entrepreneur Awards Program; A Second-Time Win For The Brand 2Health News:Mabel's Labels’ Co-Founders Named A Winner In The 2014 RBC Canadian Women Entrepreneur Awards Program; A Second-Time Win For The Brand 3Health News:How Flu Vaccines Can Impact Families Is Discussed in New Article from Community Health Center of Snohomish County 2Health News:Lice Troopers Lice Removal Service Expands in Miami-Dade 2
... A device consisting of a giant rubber tube may hold ... sea waves. , Invented in the UK, the ,Anaconda, is ... it would be cheap to manufacture and maintain, enabling it ... of wave energy converter. Cost has been a key barrier ...
... BEACH, Va., July 3 AMERIGROUP,Corporation (NYSE: AGP ... renewed its contract with the State of Tennessee,through June ... for the period April 1, 2008,through June 30, 2008, ... July 1,2008 through June 30, 2009. Expenditures on home ...
... July 3 Mylan Inc. (NYSE: MYL ... has,received tentative approval from the U.S. Food and ... (ANDA) for Linezolid,Tablets, 600 mg., Linezolid Tablets, ... Upjohn,s Zyvox(R) Tablets, which had U.S. sales of ...
... Rigel Pharmaceuticals,Inc. (Nasdaq: RIGL ) today announced that ... will present a company overview,at the Fourth Annual Collins ... a.m. EDT at The Mandarin Oriental Hotel in New ... or the subsequent archived recording,log on to http://www.rigel.com ...
... AND DUSK, DRAIN, SACRAMENTO, Calif., July 2 ... families and friends gathering outdoors, the,Mosquito and Vector ... take precautions against West Nile virus., "Individuals ... to prevent the spread of West Nile Virus ...
... long-term studies to assure medications don,t raise cardiovascular risks, ... to control type 2 diabetes should be subjected to ... the risk of heart problems, U.S. Food and Drug ... experts voted 14-to-2, at the end of a two-day ...
Cached Medicine News:Health News:Rubber 'snake' could help wave power get a bite of the energy market 2Health News:AMERIGROUP Renews Contract with Tennessee 2Health News:Remember West Nile Virus Safety This Fourth of July 2Health News:FDA Panel Calls for More Testing of Diabetes Drugs 2Health News:FDA Panel Calls for More Testing of Diabetes Drugs 3
(Date:11/26/2014)... November 25, 2014 According ... by Power Source (Electric, Battery, Pneumatic), by Product ... Burr, Cart), by Application (Orthopedic, ENT, Oral, Thoracic, ... MarketsandMarkets, the global Powered Surgical Instruments Market is estimated ... in 2014 and is expected to grow at ...
(Date:11/26/2014)... 2014 Reinforcing its commitment to enabling confident ... PHG AEX: PHIA) today announced 510(k) clearance ... its IQon Spectral CT , presenting an entirely ... adds a new dimension to Computed Tomography (CT) imaging, ... structures based on their material content within a single ...
(Date:11/26/2014)... --  Heska Corporation (NASDAQ: HSKA ) - ... advanced veterinary diagnostic and other specialty veterinary products , ... attend The Benchmark Company, LLC,s Micro Cap Discovery Conference on ... at The Palmer House Hilton, 17 E. Monroe Street, ... p.m. Please email hska@haydenir.com or contact your Benchmark ...
Breaking Medicine Technology:Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4Philips receives FDA 510(k) clearance for IQon Spectral CT 2Philips receives FDA 510(k) clearance for IQon Spectral CT 3Heska to Attend Benchmark Micro Cap Discovery Conference 2
... The Muscular Dystrophy Association today announced funding, totaling $13.7 ... nearly two dozen progressive neuromuscular diseases.  Among these are ... (DMD), nine new projects focused on ALS ... as efforts on spinal muscular atrophy (SMA), ...
... Inc., a leading manufacturer and supplier of electronic components, ... include a push-pull switch and rotary switch.  Designated the ... an extension of Bourns® Model 51/53 Series with an ... Model 56 is a new 1/2" panel control and ...
Cached Medicine Technology:Muscular Dystrophy Association Awards $13.7 Million for 40 New Research Grants 2Muscular Dystrophy Association Awards $13.7 Million for 40 New Research Grants 3Muscular Dystrophy Association Awards $13.7 Million for 40 New Research Grants 4Muscular Dystrophy Association Awards $13.7 Million for 40 New Research Grants 5Bourns Introduces Two New Industrial-Grade Panel Control Models 2Bourns Introduces Two New Industrial-Grade Panel Control Models 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: