Navigation Links
Scientists reduce protein crystal damage, improve pharmaceutical development
Date:12/18/2013

New recommendations for using X-rays promise to speed investigations aimed at understanding the structure and function of biologically important proteins information critical to the development of new drugs. Scientists from two U.S. Department of Energy national laboratories, Argonne and Brookhaven, and the University of Washington, Seattle, evaluated options to remedy problems affecting data collection in their new study.

Scientists who use powerful X-ray beams to study protein crystals face a dilemma: the beams provide the best tool for understanding a protein's structure and biological function, but they often damage the crystal, which may require repeated experiments that add time and cost to the research.

"Although X-ray crystallography is the go-to technique for determining protein structure and function, it is not without problems," said Andrzej Joachimiak at Argonne. The use of powerful X-ray beams causes radiation damage resulting in loss of data and the weak diffraction of crystals. In the end, this leads to an incomplete picture of the structure, and of how molecules interact with each other and their environment.

"The problem occurs when a protein crystal absorbs energy from incoming X-rays, which emits electrons that destroy or alter parts of the sample," Joachimiak said.

The research team examined three different X-ray-based methods for solving protein structures and recommended one called "submicrometer line focusing" as the most promising for easing the dilemma. As its name suggests, the beam strikes the protein crystal with an area smaller than a micrometer, or smaller than one thousandth of a millimeter. The tiny impact area minimizes damage. Also like its name, the beam is focused as a vertical line, delivering a more concentrated dose of X-rays per area.

The researchers also suggested using a new lens they designed that breaks the powerful beam into many mini-beams, spaced far enough apart that t
'/>"/>

Contact: Jared Sagoff
jsagoff@anl.gov
630-252-5549
DOE/Argonne National Laboratory
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists reduce protein crystal damage, improve pharmaceutical development
(Date:11/28/2014)... The report “Poxvirus Infections Pipeline ... therapeutic development for Poxvirus Infections, complete with comparative ... target, mechanism of action (MoA), route of administration ... and featured news and press releases. It also ... for Poxvirus Infections and special features on late-stage ...
(Date:11/28/2014)... November 29, 2014 Recently, PrettyTailor.com has ... dresses for its customers around the world in celebration ... customers, PrettyTailor.com has also launched a special offer on ... more. , As a pioneer in the garment industry, ... products for clients large and small. The business carries ...
(Date:11/28/2014)... The holiday season is fast approaching. As a ... collection of fashionable party dresses. What’s more, the company is ... brand new outfits; the special offer is valid until Dec. ... supplier and it has received a lot of requests for ... designed to flatter various body shapes; they are available in ...
(Date:11/28/2014)... 28, 2014 Now that the holiday ... one of the nation's leading cash-for-junk-cars companies, is improving ... to be more competitive and help bring a little ... festive time of year. , Along with purchasing expensive ... the US also deal with large travel expenses during ...
(Date:11/28/2014)... 2014 Mirena lawsuits ( http://www.mirenalawsuit2014.com/ ... New Jersey’s Bergen County Superior Court, where the ... there is quickly approaching 1,300, Bernstein Liebhard LLP ... shows 1,293 lawsuits now pending in the consolidated ... complications resulting from spontaneous migration of the birth ...
Breaking Medicine News(10 mins):Health News:Poxvirus Infections and Vestibular Diseases Pipeline Market Drugs and Companies Review H2 2014 2Health News:Poxvirus Infections and Vestibular Diseases Pipeline Market Drugs and Companies Review H2 2014 3Health News:Poxvirus Infections and Vestibular Diseases Pipeline Market Drugs and Companies Review H2 2014 4Health News:2015 Wedding Dresses from PrettyTailor.com Available Now 2Health News:Trendy Party Dresses For The Coming Holiday Season From Balfleet.com 2Health News:Rusty's Auto Salvage Increasing Their Cash Offers to Help Drivers Save Throughout the Busy Holiday Season 2Health News:Nearly 1,300 Mirena Lawsuits Now Filed in Consolidated New Jersey Litigation, Bernstein Liebhard LLP Reports 2Health News:Nearly 1,300 Mirena Lawsuits Now Filed in Consolidated New Jersey Litigation, Bernstein Liebhard LLP Reports 3
... , Key Highlights, Misys plc (LSE: MSY) ... for the next phase of the turnaround. Misys generated ... to GBP81m,37% ahead of last year. Misys is executing ... the turnaround plan, building a platform for growth., ...
... Wake Forest University Baptist Medical Center demonstrates emergency room ... heart attack, even when laboratory tests haven,t yet confirmed ... called i*trACS, and analyzed patients with heart attack symptoms ... participating U.S. centers. , The findings were released ...
... and Naturalization ready at Passport ... ... vaccine requirements will affect,anyone who is applying for an immigrant visa ... permanent residence. Applicants,must show proof of vaccinations against vaccine-preventable diseases, as,recommended ...
... in scrotum boosts sperm count, motility, study finds , , ... invasive procedure can treat a common cause of male ... baby, a new study finds. , The condition, called ... the scrotum which prevents the normal circulation of blood ...
... LOS ANGELES, July 23 Times may be tough, ... nothing like,a dazzling new smile to boost confidence. Cosmetic ... in on success, citing his,experience that a beautiful smile ... agreement is Landon Brown, who is now sporting a ...
... person had heart trouble, the worse their performance , , WEDNESDAY, ... coronary heart disease seem to fare worse on measures of ... heart disease, the worse the performance in such mental processes ... in the July 23 issue of the European Heart ...
Cached Medicine News:Health News:Misys Announces Preliminary Results for the Year Ended 31 May 2008 2Health News:Misys Announces Preliminary Results for the Year Ended 31 May 2008 3Health News:Misys Announces Preliminary Results for the Year Ended 31 May 2008 4Health News:Study shows emergency physicians have good first instincts in diagnosing heart attacks 2Health News:USCIS Tightens Vaccination Requirements 2Health News:Simple Procedure Improves Male Fertility 2Health News:Simple Procedure Improves Male Fertility 3Health News:Rock The Cradle's Bad Boy Landon Brown Owes His Irresistible New Smile to Dr. Michael Kosdon 2Health News:Coronary Disease Dulls Cognitive Skills 2
(Date:11/26/2014)... , Nov. 26, 2014 Scott Steiger ... most of the world. As an engineer for the past 20 ... member of the military service. He,s been to six of the ... Photo - http://photos.prnewswire.com/prnh/20141126/161076 Photo - http://photos.prnewswire.com/prnh/20141126/161077 ... for travelers, he has a pretty good idea of what,s required. ...
(Date:11/26/2014)... -- Zynerba Pharmaceuticals , Inc., a specialty pharmaceutical ... cannabinoid treatments, today announced that the company will present ... The conference will be held December 2 to 3, ... York . Zynerba,s Chairman and CEO, Armando ... December 2. To listen to a webcast ...
(Date:11/26/2014)... , Nov. 26, 2014 The ... at a rate of 4%, with world market ... Kalorama Information. MRI and other types of medical ... and treatment of numerous medical conditions in children ... and techniques. Kalorama,s report, Medical Imaging Markets ...
Breaking Medicine Technology:Steiger Has Created the First Pill Case Specifically Designed For Travel 2Zynerba Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2014 2Kalorama: Steady Growth in the Medical MRI Market 2Kalorama: Steady Growth in the Medical MRI Market 3
... Infinity Triglycerides powder reagent once reconstituted ... of single liquid stability to help ... and provide quick result turnaround time. ... Triglycerides powder reagent provides a long ...
... single liquid stable reagent offers the ... liquid stability to help maximize laboratory ... quick result turnaround time. The patented ... provides a long shelf life that ...
... Infinity Creatinine single liquid stable reagent ... of single liquid stability to help ... and provide quick result turnaround time. ... Creatinine reagent provides a long shelf ...
... Amylase powder reagent once reconstituted offers ... single liquid stability to help maximize ... provide quick result turnaround time. The ... powder reagent provides a long shelf ...
Medicine Products: