Navigation Links
Scientists put a pox on dog cancer
Date:9/10/2012

CHAMPAIGN, Ill. Researchers report that myxoma a pox virus that afflicts rabbits but not humans, dogs or any other vertebrates so far studied infects several different types of canine cancer cells in cell culture while sparing healthy cells. The study adds to the evidence that viruses or modified viruses will emerge as relatively benign cancer treatments to complement or replace standard cancer therapies.

The new study, reported in the American Journal of Veterinary Research, is unique in that it focused on spontaneously occurring cancers in dogs. This allowed the researchers to avoid a common practice: testing viral therapies on mice or rats with induced human cancers. Such animals must be immunosuppressed to prevent their immune systems from rejecting the foreign tissue, complicating the results.

Treating cancers with viruses could offer several advantages over standard cancer therapies, said University of Illinois veterinarian and pathobiology professor Amy MacNeill, who led the new study. Many cancers have impaired anti-viral defenses, which allow viruses to target tumors while sparing healthy cells. And under the right conditions, infection with an oncolytic (cancer-killing) virus exterminates cancer cells and elicits an anti-cancer immune response without spurring a harmful inflammatory response, she said. Chemotherapy and radiation kill healthy cells along with cancer cells and radiation can cause abrupt cell death that spurs inflammation and pain, she said.

"Ideally, what would happen is the virus would get into a few cancer cells, cause cell death and then spread to the other tumor cells nearby," she said.

Recent studies have shown that oncolytic viral therapies can be used successfully in conjunction with traditional approaches, MacNeill said.

"There was a study in cats where they removed the tumor surgically and then they put a viral therapy in the area where the tumor had been removed," she said. The animals that received the viral therapy had significantly less regrowth of the cancer than those that weren't exposed to the virus after surgery.

"Other studies (1, 2, 3, 4) have shown that once you've eliminated a cancer with an oncolytic virus, if you re-challenge that animal with the same cancer cells, they don't develop tumors," MacNeill said. Viral infection of the cancer cells appears to train the immune system to better recognize the cancer, she said.

In the new study, the researchers wanted to see if spontaneously occurring cancers in dogs were responsive to infection with a virus that is not a pathogen in humans or dogs. They found that cancerous and healthy canine cells respond as human cells do to myxoma infection: The virus invades cancer cells and leaves healthy cells alone. The team also showed that a version of the myxoma virus with a single gene deleted was four times better at killing cancer cells than the unmodified virus. The deleted gene codes for a protein that hinders cell death in infected cells.

More preliminary tests are needed and researchers have many more years of tests and trials ahead, but if all goes well they will eventually test the virus or a modified version of the virus in dogs with cancer, MacNeill said.

"We wanted to make sure that the dog cells were like the human cells because we want to use these viruses not only to cure dogs of cancer but also to use the dogs as better models for humans with cancer," she said. "People are beginning to see the logic of this approach. These dogs have spontaneous tumors just like humans, they're living in the same environment as humans, they're exposed to the same carcinogens in the water if there are any and they sometimes even share our food."

She calls this approach a "win-win" for dogs and humans.

"This way we can test the therapy in dogs while at the same time treating them," she said. "Other researchers can take our results and use them to develop therapies for human patients."


'/>"/>
Contact: Diana Yates, Life Sciences Editor
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists put a pox on dog cancer
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine ... Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this ...
(Date:6/24/2016)... ... 2016 , ... National recruitment firm Slone Partners is pleased to ... genomics experience, as Vice President of North American Capital Sales at HTG Molecular ... the sales team in the commercialization of the HTG EdgeSeq system and associated reagents ...
(Date:6/24/2016)... City, FL (PRWEB) , ... June 24, 2016 , ... ... inflammation common after venous procedures, dermaka cream can be incorporated into the post-surgical treatment ... and minor surgical procedures. , dermaka cream is very effective for bruising and ...
(Date:6/24/2016)... ... June 24, 2016 , ... SpiritQuest Sedona Retreats, located in Arizona has re-located ... famous vortex sites: Cathedral Rock, Airport Mesa, and Boynton Canyon. The new retreat ... Sedona as well as the Sedona Rouge, both popular accommodations for SpiritQuest clients. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June ... -based mobile pulmonary function testing company, is now able to ... devices developed by ndd Medical Technologies , Inc. ... done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ... , can get any needed testing done in the comfort of ...
Breaking Medicine Technology: