Navigation Links
Scientists produce nanoscale droplets with cancer-fighting implications
Date:9/3/2008

UCLA scientists have succeeded in making unique nanoscale droplets that are much smaller than a human cell and can potentially be used to deliver pharmaceuticals.

"What we found that was unexpected was within each oil droplet there was also a water droplet a double emulsion," said Timothy Deming, professor and chair of the UCLA Department of Bioengineering and a member of both the California NanoSystems Institute (CNSI) at UCLA and UCLA's Jonsson Cancer Center. "We have a water droplet inside of an oil droplet, in water."

"The big challenge," Deming added, "was to make these molecules in the sub-100-nanometer size range with these properties and have them be stable. We have demonstrated we can make these emulsions that are stable in this size range, which no one has ever been able to do before. These double nanoemulsions are generally hard to form and very unstable, but ours are very stable."

Emulsions are droplets of one liquid in another liquid; the two liquids do not mix.

"This gives us a new tool, a new material, for drug delivery and anticancer applications," said Thomas G. Mason, a UCLA associate professor of chemistry and physics who has been leading research on nanoemulsions since he joined UCLA five years ago. Mason, who holds UCLA's John McTague Career Development Chair, is also a member of the CNSI.

Deming and Mason have made nanoemulsions containing billions of double nanodroplets. Their research, reporting on droplets smaller than 100 nanometers the world's smallest double emulsions appears in the Sept. 4 edition of the journal Nature and is currently online.

"If we have water-soluble drugs, we can load them inside," Deming said. "If we have water-insoluble drugs, we can load them inside as well. We can deliver them simultaneously."

"Here, you effectively combine both types of drug molecules in the same delivery package," Mason said. "This approach could be used for a combination therapy where you want to deliver two drugs simultaneously at a fixed ratio into the same location."

It might be possible to insert a pharmaceutical inside a droplet and inject the droplet inside a cell, the scientists said. Could these droplets release their cargo inside a cell?

"We're working on it," said Deming, who designs and engineers molecules. "There's a pretty clear path on how to do that. There are still challenges for drug delivery, but we have demonstrated the key first step, that we can make these double emulsions that are stable in this size range."

The cargo could be a protein toxin that helps to kill the cell. For example, one approach might involve an anticancer drug in the oil and a toxin-protein in the water two molecules trying to kill the cell simultaneously. While a cell can develop resistance to a single drug, the combination approach can be more effective, the scientists said.

Deming and Mason caution that while this approach holds promise for fighting cancer, there are still many steps, and likely many years of research, before patients could be treated in this way. Clinical trials using this research would probably be years off.

"We'll have to do a lot of fine-tuning, but this approach has a lot of advantages," Deming said. "The size of these is a big advantage. We have discovered unique molecular features that can stabilize double emulsions. These are promising, but it's early on, and there are many ways these can fail. But we should at least learn how to make better drug-delivery vehicles."

In future research, Deming and Mason want to make sure the droplets can harmlessly enter cells and release their cargo.

The nanodroplets could potentially be used in cosmetics, soaps and shampoos as well.

Deming's laboratory is trying to take some of the key features that make proteins special and put them into synthetic materials.

"Tim has these beautiful molecules that he can design and customize," Mason said.

Deming saw Mason give a UCLA talk about simple nanoemulsions in which Mason was coating nanoscale oil droplets in water using natural proteins; the two agreed to try to combine the advantages of their materials, and their collaboration was born. Both scientists said working together has been "fantastic."

Emulsions are a way of taking an oil, which doesn't mix with water, and putting it in a water-friendly environment, where, dispersed as droplets, it behaves like a fluid. Emulsions have complex properties and are found in many products, including foods, plastics, cosmetics, oil and paints.

"In the emerging field of nanoemulsions, this research is a big step," Mason said.


'/>"/>
Contact: Phil Hampton
phampton@support.ucla.edu
310-206-1460
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... California (PRWEB) , ... May 03, 2016 , ... Cosmetic ... practice in late 2014, incorporating the injectable filler into his menu of services ... aesthetic transformation. Now, more than a year later, he’s still improving his approach to ...
(Date:5/3/2016)... FORT WORTH, Texas (PRWEB) , ... May 03, 2016 , ... ... some of the signs of pet anxiety. "Pet owners often think anxiety only ... be sending stress signals in other ways, and there’s things that be done about ...
(Date:5/3/2016)... Texas (PRWEB) , ... May 03, 2016 , ... ... today announced that it is launching a new client service center in La ... Houston, Texas, and will provide the full range of Empyrean client services. , ...
(Date:5/3/2016)... ... , ... Each year, about 800,000 people suffer from cerebral vascular accidents, or ... account for one death every four minutes. Many people who survive a stroke ... launching a video series called “Your Brain,” in conjunction with its medical journal “Balance,” ...
(Date:5/3/2016)... Indianapolis, IN (PRWEB) , ... May 03, 2016 ... ... employee benefits advisory organization, announces Benefits Alliance Insurance Services as the latest addition ... powerhouse Southern California-based Firm comprised of Partners Wayne Blasman, David Styles, and Paul ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... excited to announce the launch of its Mediceutical line of products, a line of ... of clinical conditions. Founded in 2013, Forté spent more than two years researching and ... http://photos.prnewswire.com/prnh/20160502/362547LOGO ... ... ...
(Date:5/2/2016)... , May 2, 2016 Kalorama Information ... (Electronic Medical Records) market in a recent white paper.  ... switches, Increased physician usage, a growing market are among ... noted in Kalorama,s report EMR 2016: The ... marks Kalorama,s seventh complete study of the EMR industry, ...
(Date:5/2/2016)... 2, 2016  While nearly three-quarters of Americans (71%) ... on their health, only about half report taking any ... results of a new survey announced today by Hologic ... of National Osteoporosis Month, Hologic is raising awareness of ... 56 million Americans. Osteoporosis is a disease ...
Breaking Medicine Technology: