Navigation Links
Scientists pinpoint bladder cancer patients who could benefit from 'tumor-softening' treatment
Date:7/30/2014

Scientists in Manchester have identified a protein that could help doctors decide which bladder cancer patients would benefit from a treatment that makes radiotherapy more effective, according to a study* published in the British Journal of Cancer (BJC).

The team from The University of Manchester, funded by the Medical Research Council, found that patients whose bladder tumour had high levels of a protein, called 'HIF-1α', were more likely to benefit from having carbogen oxygen mixed with carbon dioxide gas and nicotinamide tablets at the same time as their radiotherapy. The treatment, called 'CON', makes radiotherapy more effective.

By comparing levels of HIF-1α in tissue samples from 137 patients who had radiotherapy on its own or with CON, the researchers found the protein predicted which patients benefited from having CON. High levels of the protein were linked to better survival from the disease when patients had radiotherapy and CON. Patients with low protein levels did not benefit from having CON with their radiotherapy.

The HIF-1α protein indicates low oxygen levels in tumour cells a state known as 'hypoxia'. The CON treatment works by adding oxygen to the oxygen-deprived tumour cells which makes them more sensitive to the radiotherapy.

Study author, Professor Catharine West, a Cancer Research UK scientist at The University of Manchester, said: "Although we have another biomarker that can predict responsiveness to CON and radiotherapy in bladder cancer patients, our findings tell us a bit more about the characteristics of bladder cancer tumours and how they may respond to this treatment."

"But we desperately need to do more work to find ways to treat those patients who won't see as much benefit from this.

"And it's exactly this type of vital research that we and other scientists will be doing at the Manchester Cancer Research Centre bringing together a wide range of expertise to revolutionise cancer treatment."

Around 65 people are diagnosed with bladder cancer in Manchester every year**. There are around 25 deaths from the disease every year***.

Nell Barrie, senior science communications manager at Cancer Research UK, said: "This fascinating new finding could help doctors adapt their treatments to patients with bladder cancer as well as shedding more light on the disease.

"Deaths from bladder cancer are falling in the UK, but more work needs to be done so that this trend continues. More research is needed to helps us find new and better ways to fight bladder cancer."


'/>"/>

Contact: Flora Malein
flora.malein@cancer.org.uk
44-203-469-8300
Cancer Research UK
Source:Eurekalert

Related medicine news :

1. Scientists to study hereditary breast cancer to find BRCA1 treatment
2. Drexel Scientists Develop Compound to Stop Spread of Metastatic Cancer Cells
3. Scientists test nanoparticle alarm clock to awaken immune systems put to sleep by cancer
4. Brain Tumor Causes and Risk Factors Elude Scientists
5. Brain tumor causes and risk factors elude scientists
6. Mount Sinai Scientists and International Team Shed New Light on Schizophrenia in Largest Genomic Study Published to Date
7. NIH-supported scientists demonstrate very early formation of SIV reservoir
8. Scientists Snipped HIV Out of Human DNA
9. Scientists Discover New Way to Make Human Platelets
10. Scientists find new clues to brains wiring
11. Scientists Spot Gene Behind Rare but Fatal Disease in Children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... , ... The results from the American Cancer Society’s newest report ... cancer patients: incidents of cancer is down as is the likelihood of prostate cancer ... has dropped from its peak of 215.1 in 1991 to 161.2 in 2014 (per ...
(Date:1/24/2017)... ... 2017 , ... A yellow fever outbreak in Brazil has infected over 100 ... primarily spread through contact with infected mosquitos. The outbreak has sparked increased concern about ... , According to multiple health organizations, the best way to prevent yellow fever is ...
(Date:1/24/2017)... ... January 24, 2017 , ... “Spiritual ... improve the connection with God. “Spiritual Vitamins: A Spiritual Energy Booster” is the ... Christian Faith Publishing, Mathai Yohannan’s new book engages the mind and spirit in ...
(Date:1/24/2017)... ... January 23, 2017 , ... CLICKco ... and espresso drink, announced its CLICK® Coffee Protein Drink is now available for ... Drink Mix has become popular among health-conscious consumers who love coffee but are ...
(Date:1/24/2017)... Dallas, Texas (PRWEB) , ... January 23, 2017 ... ... expanding its presence in Texas with the acquisitions of two personal care service ... (PAS), in Texas City, Texas, effective January 1, 2017. , Well regarded in ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... Calif. , Jan. 23, 2017  HOPE ... exclusive rights to develop and commercialize nuc ... Therapeutics, a Korean pharmaceutical company. ... DNA aptamer against surface nucleolin found on many ... gemcitabine. Unlike ADCs (antibody drug conjugates) or SMDCs ...
(Date:1/23/2017)... YORK , Jan. 23, 2017 Consolidated ... Partners and Driving the Stability Testing Outsourcing Market ... market addresses market sizing, emerging trends, and technologies, and ... market. The base year is 2015 and forecasts are ... is expected to grow at a CAGR of 9.4% ...
(Date:1/23/2017)... 2017 MouthWatch LLC announced today that its flagship ... the best intraoral camera on DentalCompare,s list of Top ... The #1 product was the CollaPlug Absorbable Collagen Wound ... was "…incredibly popular because it is by far the most ... sticker price, it doesn,t sacrifice quality imaging." ...
Breaking Medicine Technology: