Navigation Links
Scientists move towards stem cell therapy trials to mend shattered bones
Date:2/18/2008

The UK Stem Cell Foundation, the Medical Research Council and Scottish Enterprise, in partnership with the Chief Scientists Office, are funding a 1.4 million project to further the research at the University of Edinburgh with a view to setting up a clinical trial within two years.

The initiative could have a major impact on treating conditions such as osteoarthritis as well as treating trauma victims whose bones have been shattered beyond repair.

It involves using a bioactive scaffold made to protect the stem cells and simulate their growth into bone or cartilage once they are placed in the affected area. The scaffold consists of a fairly rigid mesh structure, coated or impregnated with a drug that affects the patients cells.

Dr Brendon Noble, of the University of Edinburghs MRC Centre for Regenerative Medicine, said: This is a novel approach in terms of treating damaged bones and cartilage. The aim is to translate the knowledge we have gained from bone biology studies into tangible treatments for patients.

Researchers will also work with clinicians, headed by Hamish Simpson, professor of orthopaedics and trauma at the University of Edinburgh, with a view to eventually translating their findings into treatments for patients.

As well as using cells derived from bone marrow, the scientists will work in collaboration with the Scottish National Blood Transfusion Service to culture bone forming cells derived from blood.

The advantage of these blood-sourced cells is that they can be extracted without the need for surgery. The use of a patients own stem cells means that they are also unlikely to be rejected.

Dr Anna Krassowska, research manager for the UK Stem Cell Foundation said: In the UK hip fractures kill 14,000 elderly people every year - more than many cancers. The worldwide market for orthopaedic devices alone represents some $17 billion. This research has the potential not only to impact on a significant number of people's lives but to open up one of the largest stem cell markets in the industry.

For nearly a decade, scientists have known broadly the right chemical conditions required to encourage undifferentiated stem cells taken from a patient's bone marrow to change into bone and cartilage cells in the laboratory. However, the use of the bioactive scaffold being developed at the University of Edinburgh aims to enable these cells to grow within the human body. The initial clinical trial, resulting from the laboratory work is likely to involve around 30 patients.


'/>"/>

Contact: Tara Womersley
tara.womersley@ed.ac.uk
01-316-509-836
University of Edinburgh
Source:Eurekalert

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2017)... , ... April 22, 2017 ... ... of Eastern Pennsylvania has named PROSHRED® Security of Philadelphia its “Woman-Owned ... PROSHRED® Philadelphia specializes in providing information destruction , recycling, and ...
(Date:4/21/2017)... ... April 21, 2017 , ... An April 10 article ... of ancient teeth, which reveal a great deal about prehistoric ice-age dental practitioners and ... may have been used to remove decayed dental matter, and that teeth were then ...
(Date:4/21/2017)... ... April 21, 2017 , ... Chicago plastic surgeon, Dr. Anil R. Shah, ... is a benign bony lump located on the forehead usually attributed to a facial ... sight and pain. Dr. Shah has discovered an approach that is minimally invasive. He ...
(Date:4/21/2017)... ... 2017 , ... Dudnyk has announced the launch of its new brand identity, ... potential of specialty and orphan brands can only be achieved when the needs and ... Effect is at the heart of a true partnership between our agency and our ...
(Date:4/21/2017)... Hong Kong (PRWEB) , ... April 21, 2017 , ... ... Printing (U3DP), the first 3D printing facility among higher education institutions in Hong Kong ... 3D printing, in terms of the range and quantity of facilities in Hong Kong. ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 19, 2017  Sorrento Therapeutics, Inc. (NASDAQ: ... company developing new treatments for cancer and other ... its previously announced underwritten public offering of 23,625,084 ... offering price of $2.00 per share, before deducting ... payable by Sorrento.  The net proceeds to Sorrento ...
(Date:4/19/2017)... HANOVER, N.J. , April 19, 2017 /PRNewswire/ ... conducted by the National Heart, Lung, and Blood ... (NIH) demonstrating that 58% of patients with treatment-naïve ... six months when treated with eltrombopag at the ... 1 . The study evaluated three sequential treatment ...
(Date:4/18/2017)... MINNEAPOLIS , April 18, 2017 Cogentix ... focused on providing the Urology, Uro/Gyn and Gynecology markets ... for the first quarter ended March 31, 2017 after ... The Company will host a conference call ... day on Tuesday, May 2, 2017 at 4:30 p.m. ...
Breaking Medicine Technology: