Navigation Links
Scientists make your stomach turn bright green if you have an ulcer
Date:1/8/2014

Doctors may soon be able to diagnose stomach ulcers without taking tissue samples from the stomach. Researchers from the University of Southern Denmark now report to have developed a new, safer and noninvasive diagnostic technique for ulcers. The trick is to make the ulcer-causing bacteria in the gut light up in fluorescent green.

Each year, many patients are examined for ulcers, and this is often done by retrieving a tissue sample from the stomach. This requires that the doctor sends an instrument down into the patients stomach, and the patient must wait for the tissue sample to be analyzed before the doctor can give information about a possible ulcer.

Now researchers from University of Southern Denmark are developing a diagnostic technique that makes it possible to detect the ulcer instantly. It shortens the patient's unease and it improves the doctor's opportunity for early diagnosis.

"Early diagnosis does not only prevent ulcers from developing, it can also prevent the development of cancer", says Ph.D. student Silvia Fontenete from the Nucleic Acid Center at the University of Southern Denmark/Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto in Portugal. She is the lead author of an article on the research results in journals PLOS ONE.

Ulcers are often caused by the bacteria Helicobacter pylori, which produces ulcers in the stomach or duodenum. Usually the doctor retrieves a tissue sample from the stomach and has it analyzed. You can also take a breath test, where molecules in the patient's breath are analyzed, but this technique is not always reliable, says Silvia Fontenete.

Scientists have for some time been able to make tissue samples from the stomach glow fluorescent green if the tissue is infected with H. pylori bacteria. For this the scientist will need to retrieve a piece of the stomach for analysis in the laboratory.

The researchers' new approach is to make the stomach glow bright fluorescent green WITHOUT taking tissue samples from it.

"Our laboratory experiments suggest that one day it will be possible for doctors to send some specially designed molecules down in the stomach, where they will make H. pylori glow brightly green", explains Silvia Fontenete.

To see the green light the doctor will send a small micro-camera into the stomach.

The scientists report to have made H. pylori glow green in artificial tissue in the laboratory - this was tissue that mimics the lining of the human stomach.

"We believe that the same can happen in a real human stomach", says Silvia Fontenete.

To achieve their results, the researchers had to overcome two major challenges: The first challenge was to create the special molecules that can both detect H. pylori bacteria and function at approx. 37 degrees Celsius, which is the temperature of the human stomach. The second challenge was that the molecule should be able to function in the extremely acidic environment of the stomach.

Both challenges were solved by working with the so-called Locked Nucleic Acid (LNA), some special synthetic molecules developed by Silvia Fontenente's research director, Professor Jesper Wengel at University of Southern Denmark. LNA are artificial RNA-like molecules which can bind to microRNA molecules. They are extremely stable and can operate at lower temperatures and in more acidic environments than other molecules.

"We have been lucky: The first molecules I created turned out to do the job right away. I could have been more unfortunate, and it would have taken several years", says Silvia Fontenete.


'/>"/>
Contact: Birgitte Svennevig
birs@sdu.dk
University of Southern Denmark
Source:Eurekalert  

Related medicine news :

1. Scientists reduce protein crystal damage, improve pharmaceutical development
2. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
3. Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
4. Scientists discover that short-term energy deficits increase factors related to muscle degradation
5. CNIO scientists create the first large catalog of interactions between drugs and proteins
6. Over 70 new centers to train tomorrows engineers and scientists
7. Scientists Agree: Sleep Less, Get Fat
8. UNC scientists find potential cause for deadly breast cancer relapse
9. Western University cancer researcher teams up with Chinese scientists to study chemotherapy
10. Scientists show how cells protect their DNA from catastrophic damage
11. Scientists far from finish line in understanding anemia in female athletes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists make your stomach turn bright green if you have an ulcer
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... This campaign ... a stroke, which we as a society can control and change. , As nearly ... nearly every 40 seconds within the United States. Plus, with an estimated 129,000 of ...
(Date:5/27/2016)... ... , ... Beleza Medspa has initiated a new program to assist ... first time that Coolsculpting is being used for for more than just cosmetic purposes. ... meet the prescribed body-fat standard, measured by the circumference-based tape method. The tape-test ...
(Date:5/27/2016)... ... May 27, 2016 , ... Each ... studying complementary medicine. Allison Outerbridge is this year’s Life University winner ... 18 at the university’s Student Leadership Awards ceremony. , Outerbridge is approaching her ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... There are ... Hot Dog and Sausage Council (NHDSC) suggests that Americans prefer their dogs straight off ... 63 percent say grilling is their favorite way to cook a hot dog, far ...
(Date:5/26/2016)... Missouri (PRWEB) , ... May 26, 2016 , ... ... quality and clinical outcomes, hosted members and suppliers for its inaugural Member Conference ... focus on their mission of elevating the operational health of America’s healthcare providers. ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... Tenn. , May 26, 2016 /PRNewswire/ ... of software and analytics, network solutions and ... today announced it entered into a strategic ... provider of outpatient software solutions and revenue ... centers, specialty hospitals and rehabilitation clinics to ...
(Date:5/25/2016)... , May 25, 2016 According ... by Type (3D, 2D, 4D), by Therapeutic Area (Oncology, ... End User (Medical Device Manufacturers, Hospitals/ Clinics) - Forecast ... global Medical Animation Market for the forecast period of ... USD 301.3 Million by 2021 from USD 117.3 Million ...
(Date:5/25/2016)... 25, 2016  Zymo Research Corp. announced today ... reference materials that help researchers obtain the most ... analyses. The rapid growth of the study of ... have standard methods to improve the reproducibility and ... exist at every step of the measurement process ...
Breaking Medicine Technology: