Navigation Links
Scientists look at 'syringe' assembly in plague bacteria

Bacteria that cause the bubonic plague avoid death in our bodies by injecting our cells with immune evasion proteins. Scientists have discovered a new way bacteria build and hold the syringes, according to research published in the journal Microbiology.

Some pathogenic bacteria have a complex injection device made of many proteins. This molecular syringe has to be attached across two membranes so that proteins can be passed from the bacterial cells into human cells.

Until now, scientists thought that the position of a key lipoprotein component of the syringe was determined by one or two specific amino acids as is true for all other bacterial lipoproteins. But research led by Dr Gregory Plano at the University of Miami Miller School of Medicine suggests that location is not always determined by these previously identified sorting signals.

The YscJ lipoprotein in Yersinia pestis is an essential part of the injection device, says Dr Plano. It serves as a platform for the syringe to be built on and it is a major component of the structure that links the two bacterial cell membranes together. The sequence of YscJ suggests that it should be attached to the outer membrane, but it is actually attached to the inner membrane of the bacterial cell. Instead of being controlled by a few key amino acids, the location of the YscJ lipoprotein is determined by the presence of a specific section of the protein.

Injection devices help pathogenic bacteria to survive in our bodies by injecting proteins that stop our immune cells from communicating and launching an attack. Some bacteria that are beneficial to plants and animals also use these devices to evade their hosts immune systems.

Understanding this mechanism tells us more about how Yersinia pestis causes plague. We now want to find out why the YscJ protein uses this unusual mechanism instead of the traditional method used by other lipoproteins, says Dr Plano.


Contact: Lucy Goodchild
Society for General Microbiology

Page: 1

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/27/2016)... ... 27, 2016 , ... recently awarded their highest five-star rating to Best ... individuals in the United States and Canada wear eyeglasses. Once considered to be a ... and make a fashion statement. Even celebrities use glasses as a way of creating ...
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... On ... as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle ... honor of the city’s history as home to some of the world’s leading providers ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 ... value-based care operating models within the health care industry ... greater financial efficiency , Deloitte offers a suite ... key business issues impacting efficient cost optimization: labor resource ... , These services facilitate better outcomes and better economics ...
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
Breaking Medicine Technology: