Navigation Links
Scientists look at 'syringe' assembly in plague bacteria
Date:2/27/2008

Bacteria that cause the bubonic plague avoid death in our bodies by injecting our cells with immune evasion proteins. Scientists have discovered a new way bacteria build and hold the syringes, according to research published in the journal Microbiology.

Some pathogenic bacteria have a complex injection device made of many proteins. This molecular syringe has to be attached across two membranes so that proteins can be passed from the bacterial cells into human cells.

Until now, scientists thought that the position of a key lipoprotein component of the syringe was determined by one or two specific amino acids as is true for all other bacterial lipoproteins. But research led by Dr Gregory Plano at the University of Miami Miller School of Medicine suggests that location is not always determined by these previously identified sorting signals.

The YscJ lipoprotein in Yersinia pestis is an essential part of the injection device, says Dr Plano. It serves as a platform for the syringe to be built on and it is a major component of the structure that links the two bacterial cell membranes together. The sequence of YscJ suggests that it should be attached to the outer membrane, but it is actually attached to the inner membrane of the bacterial cell. Instead of being controlled by a few key amino acids, the location of the YscJ lipoprotein is determined by the presence of a specific section of the protein.

Injection devices help pathogenic bacteria to survive in our bodies by injecting proteins that stop our immune cells from communicating and launching an attack. Some bacteria that are beneficial to plants and animals also use these devices to evade their hosts immune systems.

Understanding this mechanism tells us more about how Yersinia pestis causes plague. We now want to find out why the YscJ protein uses this unusual mechanism instead of the traditional method used by other lipoproteins, says Dr Plano.


'/>"/>

Contact: Lucy Goodchild
l.goodchild@sgm.ac.uk
44-011-898-81843
Society for General Microbiology
Source:Eurekalert

Page: 1

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
(Date:10/12/2017)... ... 12, 2017 , ... Information about the technology: , Otomagnetics ... enable prevention of a major side effect of chemotherapy in children. Cisplatin and ... For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will join ... International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey Dome, ... at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division of ...
(Date:10/12/2017)... ... 2017 , ... Health Literacy Innovations (HLI), creator of the ... the Cancer Patient Education Network (CPEN), an independent professional organization that shares best ... alliance. , As CPEN’s strategic partner, HLI will help support CPEN members ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical ... innovative solutions for injectable drug administration, today shared the ... ID Adapter for improving the intradermal administration of polio ... Skin Vaccination Summit in May 2017 by Dr. ... Polio Department, World Health Organization (WHO), and recently published ...
(Date:10/4/2017)... 2017  According to the Centers for Disease Control and Prevention (CDC), ... PhysicianOne Urgent Care is helping communities across Massachusetts , ... by offering no-cost* flu shots through the end of the month. ... insurance regulations. ... get a flu shot is by the end of October, according to ...
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, the ... by Walgreens and pharmacy benefit manager Prime Therapeutics LLC ... brand, which included the unveiling of new signage at ... as well as at a few other company-owned facilities ... brand to patients, some of whom will begin to ...
Breaking Medicine Technology: