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Scientists investigate potential markers for a response to sunitinib in patients with metastatic RCC
Date:3/18/2013

accompanied by a reduced VHL protein staining and an increased CA9 score.

After 9 months, 45% of the patients responded to sunitinib treatment. Their response was associated with low Fuhrman grade of the primary tumour (p<0.05). The vessel staining of VEGFR1/2 was elevated in patients with a response after last report.

Patients with a response after 6 months exhibited an increased MVD and CA9 staining in the primary tumour (p<0.05) and their estimated median progression free survival (12 mo vs. 8 mo; p<0,001) and median overall survival (45 mo vs. 21 mo; p<0.001) was longer than for non-responders. High CA9 and low PDGFRα; protein expression were associated with longer overall survival (p<0.01).


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Contact: Ivanka Moerkerken
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

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