Navigation Links
Scientists image beginning stages of ovarian cancer growth with time-lapse technique

PHILADELPHIA Scientists at Harvard University have created a laboratory model using time-lapse video microscopic technology that allows observation of early stages of ovarian cancer metastasis.

"We were able to observe key molecular mechanisms that are necessary for the force-dependent processes associated with metastasis," said Joan Brugge, Ph.D., professor and chair of cell biology at Harvard University.

These findings are published in Cancer Discovery, the newest journal of the American Association for Cancer Research. According to Brugge, who served as program chairperson for the AACR 102nd Annual Meeting 2011, ovarian cancer cells spread throughout the peritoneum by attaching to the outer cell layer of organs in this area and then clearing away this layer of cells and embedding themselves on the organ, where they then proliferate and expand.

"The reason these tumors are so morbid is that the metastatic tumors grow large enough to interfere with the function of the organs in the peritoneum," she said.

By using the time-lapse video microscopic technique, Brugge and colleagues were able to visualize the detailed sequence of events associated with insertion of tumor cells into peritoneal monolayers in cell culture, and then determine that the mechanism involves tumor cells' use of force via 5 integrin, talin I and muscle myosin II.

"Theoretically, by targeting these molecules, it may be possible to prevent the formation of new metastatic tumors," said Brugge.


Contact: Jeremy Moore
American Association for Cancer Research

Page: 1

Related medicine news :

1. Scientists identify key component in lethal lung cancer complication
2. Swine flu spread was much wider than first thought, scientists say
3. Einstein scientists find crucial molecule involved in spread of breast cancer
4. Scientists create humanized mouse model for hepatitis C
5. Scientists unlock potential of frog skin to treat cancer
6. The New York Stem Cell Foundation awards fellowships to 7 innovative stem cell scientists
7. UCSB scientists discover new direction in Alzheimers research
8. Indiana University neuroscientists map a new target to wipe pain away
9. NIH scientists reactivate immune cells exhausted by chronic HIV
10. Scientists identify overactive genes in aggressive breast cancers
11. Tie Between Biomarkers, Disease Often Overstated, Scientists Say
Post Your Comments:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating ... many ways they remain in the eye of the beholder, according to experts who ... of The American Journal of Managed Care. For the full issue, click here ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, ... editors can give their videos a whole new perspective by using the title ... Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to choose ...
(Date:6/26/2016)... ... 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop ... The fitness app plans to fix the two major problems leading the fitness industry today:, ... all type program , They don’t eliminate all the reasons people quit their ...
(Date:6/25/2016)... Washington, D.C. (PRWEB) , ... June 25, 2016 ... ... will discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June ... share their work on several important health care topics including advance care planning, ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... WAYNE, Pa. , June 23, 2016 ... provider, will launch its next generation clinical outcomes platform, Bracket ... DIA Meeting held on June 26 – 30, 2016 in ... 6.0, the first electronic Clinical Outcome Assessment product of its ... DIA Booth #715. Bracket eCOA 6.0 is a ...
(Date:6/23/2016)... , June 23, 2016 Revolutionary ... Oticon , industry leaders in advanced audiology ... of Oticon Opn ™, the world,s first internet ... possibilities for IoT devices.      (Photo: ... introduces a number of ,world firsts,: , ...
(Date:6/23/2016)... FRANKLIN, Tenn. , June 23, 2016 ... for automating, integrating and transforming the patient ... launch of several innovative new products and ... depth of its revenue cycle offerings. These ... establish more efficient workflows, remain compliant in ...
Breaking Medicine Technology: