Navigation Links
Scientists image a single HIV particle being born
Date:5/25/2008

A mapmaker and a mathematician may seem like an unlikely duo, but together they worked out a way to measure longitude and kept millions of sailors from getting lost at sea. Now, another unlikely duo, a virologist and a biophysicist at Rockefeller University, is making history of their own. By using a specialized microscope that only illuminates the cells surface, they have become the first to see, in real time and in plain view, hundreds of thousands of molecules coming together in a living cell to form a single particle of the virus that has, in less than 25 years, claimed more than 25 million lives: HIV.

This work, published in the May 25 advanced online issue of Nature, may not only prove useful in developing treatments for the millions around the globe still living with the lethal virus but the technique created to image its assembly may also change the way scientists think about and approach their own research.

The use of this technique is almost unlimited, says Nolwenn Jouvenet, a postdoc who spearheaded this project under the direction of HIV expert Paul Bieniasz and cellular biophysicist Sandy Simon, who has been developing the imaging technique since 1992. Now that we can actually see a virus being born, it gives us the opportunity to answer previously unanswered questions, not only in virology but in biology in general.

Unlike a classical microscope, which shines light through a whole cell, the technique called total internal reflection microscopy only illuminates the cells surface where HIV assembles. The result is that you can see, in exquisite detail, only events at the cell surface. You never even illuminate anything inside of the cell so you can focus on what you are interested in seeing the moment it is happening, says Simon, professor and head of the Laboratory of Cellular Biophysics.

When a beam of light passes through a piece of glass to a cells surface, the energy from the light propagates upward, illumin
'/>"/>

Contact: Thania Benios
tbenios@rockefeller.edu
212-327-7146
Rockefeller University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cold Spring Harbor scientists reveal a proteins role in enabling AIDS virus to reproduce
2. Pittsburgh scientists find protein may be key to new therapies for elevated triglycerides
3. BWF awards $11.2 million to support physician-scientists
4. Nu Skin Scientists Identify Additional Free Radical Generator
5. CSHL scientists are part of consortium that sequences platypus genome
6. Scientists identify key roadblock to gene expression
7. Scientists identify interacting proteins key to melanoma development, treatment
8. The American Psychiatric Associations Awards for Young Scientists Encourage Research Expertise in China
9. Scientists identify gatekeepers of breast cancer transition to invasive disease
10. Scientists at Yale provide explanation for how cancer spreads
11. Brookhaven scientists explore brains reaction to potent hallucinogen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in ... Player Health Alliance (PPHA). The PPHA's passion for others' ... including NFL greats, treated for obstructive sleep apnea (OSA) has ... the cause in the valley. The most recent plans for ...
(Date:1/22/2015)... 22, 2015 The Incredible Bulk is a ... to increase lean muscle by up to 30lbs in less ... attention of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , ... a step-by-step, scientific diet formula that allows the body to ...
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue Cross) wants ... “Live Fearless.” , The “Faces of Fearless” campaign ... how they or someone they know has faced a challenge, ... moment. By telling these types of stories through livefearlessmn.com, participants ...
(Date:1/22/2015)... New York (PRWEB) January 22, 2015 The ... ) in the U.S. District Court, Southern District of West ... Bard, Inc. in that proceeding’s first bellwether trial. In an ... for a new trial after finding that C.R. Bard had ...
(Date:1/22/2015)... A new white paper by The ... in the long-term care environment as well as provides ... The paper, “The Power of Person-Centeredness in Long-Term Care: ... of the patient, resident and family experience in long-term ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3
... the pulmonary division at National Jewish Medical and Research Center ... before bedtime and asthma medicines in the late afternoon to ... the fact that body behaviour is not the same at ... the circadian rhythms influences allergy and asthma. "Taking your ...
... herself and her new born proud. The mama is the first ... was conceived with a frozen egg and sperm.// ,The ... her chances of having a baby with the conventional method. Apparently, ... hopes of having a baby, something she wanted more than anything ...
... decision to adopt much of Federal Government’s preferred model ... and accreditation of training for each of the nine ... said that overall this is great news for the ... there will be nationally consistent standards for registration and ...
... in Afghanistan are increasingly suffering from war–related anxiety and ... ,Ontario’s ombudsman Andre Marin had undertaken a recent ... center for treatment of such traumatized children was caught ... bodies unwilling to take financial responsibilities. ,Mr. ...
... notices to All India Institute of Medical Sciences (AIIMS) ... filed by a former patient alleging// that the state-run ... from patients undergoing treatment at its cardiac and neuro ... notices Thursday to Venugopal, Mayank Sharma, former senior financial ...
... team of UK scientists have undertaken what is described as ... ,Their findings will mark the biggest single leap in the ... opening the door to a new wave of tailored therapies ... a serious illness. ,A coalition of 50 groups, ...
Cached Medicine News:Health News:COAG Gets It Mostly Right On National Registration 2Health News:Collateral Damage-Children Of Canadian Soldiers Suffer 2Health News:Court Issues Notice to Venugopal Over Fund Irregularities 2Health News:UK Scientists to Reveal Genetic Secrets Behind Serious Illnesses 2
(Date:1/23/2015)... MOINES, Iowa , Jan. 23, 2015  The Partnership to Fight ... Iowa health care leaders and a new study analyzing ... medications. The PFCD is a nationwide coalition working to educate policy ... research released at the Capitol was focused on how the ...
(Date:1/23/2015)... than a third of reproductive-aged women enrolled in Medicaid, and ... a prescription for an opioid pain medication each year during ... Mortality Weekly Report (MMWR). Opioids are typically ... pain.  They are also found in some prescription cough medications. ...
(Date:1/23/2015)... 23, 2015  HyGreen, Inc., a leader in hand hygiene ... RCA Medical, a subsidiary of Ascendis Health Limited, in ... Each year, hundreds of millions of patients around the ... are transmitted from patient to patient via the unwashed ...
Breaking Medicine Technology:New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3HyGreen Partners with RCA Medical in Johannesburg, South Africa 2
... 23 The Public Patent,Foundation ("PUBPAT") announced today that ... HIV/AIDS drug patents held by Gilead Sciences,that relate to ... key weapon in the battle against HIV/AIDS. Gilead markets ... and as a part of its ATRIPLA,combination product., ...
... Ala., Jan. 23 BioCryst,Pharmaceuticals, Inc. (Nasdaq: ... on activities,conducted following release of the preliminary ... development plan for intramuscular (i.m.) peramivir., ... release of preliminary Phase II results in ...
Cached Medicine Technology:U.S. Patent Office Rejects Key HIV/AIDS Drug Patents at PUBPAT Request: Government Finds Prior Art Submitted By PUBPAT Invalidates All of Gilead Sciences' Claims 2BioCryst Updates Peramivir Clinical Development Plan 2BioCryst Updates Peramivir Clinical Development Plan 3BioCryst Updates Peramivir Clinical Development Plan 4BioCryst Updates Peramivir Clinical Development Plan 5BioCryst Updates Peramivir Clinical Development Plan 6
Two point fixation, tips separated by 13 mm. Each tip has 0.12 mm, 1 x 2 teeth. Wide serrated handle with thumb catch lock and dull finish....
... A simple, effective method for determining color ... reliable data which can be applied to ... The set consists of four trays containing ... caps that have incremental hue variation on ...
... Farnsworth 100 Hue Test including MS-Excel scoring template ... Farnsworth 100 Hue Test comes boxed in clear ... the potential for test disruption by holding ... test from Richmond Products includes 93 color discs, ...
... modification of the Farnsworth-Munsell 100 Hue Test. It ... the in-depth study of a color vision defect. ... ease or difficulty in distinguishing color differences in ... 15 color reference caps with Munsell notations, plus ...
Medicine Products: