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Scientists identify strategies to conquer lifestyle and genetic factors related to chronic diseases
Date:12/7/2011

10 key recommendations as having the highest priority for research into chronic inflammatory diseases:

  1. Research should distinguish between therapy and prevention.
  2. Large prospective cohort studies including deep phenotyping should be made a priority.
  3. Research should focus on the question of tolerance.
  4. A global (international) approach should be taken to understanding chronic inflammatory disease.
  5. Effective interdisciplinary research strategies must be established.
  6. New tools and experimental models must be developed.
  7. Protocols for data collection, handling, and storage need to be harmonized.
  8. Substantial investment must be made in infrastructure, personnel, and development of research tools.
  9. Dedicated funding must be provided for interdisciplinary research.
  10. Effective public-private partnerships must be developed to ensure free exchange of information.

Furthermore, the committee pointed to a series of key strategic research targets for which significant progress in the management of chronic diseases may be achieved.

Therapy and Prevention. Given the complexity of chronic inflammatory diseases, therapies must be based on deep environmental, clinical and biological phenotyping of patients. Without deep phenotyping, it is impossible to determine whether a potential therapy is clinically ineffective or simply inappropriately targeted. The committee calls for the identification of novel biological markers to enhance patient stratification, and for investments in bioinformatics and systems biology to realize the full potential of omics data.

For prevention, key issues include the selection of appropriate populations and the long-term tolerability of putative long-term protective agents. The results of clinical studies of probiotics as infant food supplements to prevent allergic disease have been mixed. The committee recommends that the term probiotic be employed with caution
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Contact: Terrie DuHadway
jacimedia@elsevier.com
314-447-8133
Elsevier Health Sciences
Source:Eurekalert

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