Navigation Links
Scientists identify potential new target for treating triple negative breast cancer
Date:11/16/2010

, but the researchers tested it to see whether inhibiting ADAM and EGFR simultaneously would work synergistically. "We did not observe any additional benefit when we combined the ADAM inhibitor with gefitinib; however, adding gefitinib 72 hours after ADAM inhibitor treatment was more effective than adding both inhibitors simultaneously, although this did not reach statistical significance."

In addition, another, as yet un-named compound that blocks both ADAM10 and ADAM17 resulted in significant effect on a range of TNBC cell lines. "We found that it reduced the growth of these cells by up to 91%," she said. "We have also found that treatment of TNBC cells with this compound reduced their ability to migrate, a process that is vital for the progression of cancer.

"Triple negative breast cancers comprise 10-20% of all breast cancer cases. Women with TNBC tend to present with higher grade, larger tumours, are younger at diagnosis, have a higher incidence of metastases and have a shorter time to recurrence compared to other breast cancer types. One reason for the poor prognosis for this group is the lack of targeted therapies for these women. Having found that an ADAM inhibitor can reduce the proliferation of TNBC cell lines, we hope that ADAMs may be a useful therapeutic target."

The scientists hope that inhibiting ADAMs might also be a possible treatment for other cancers in which members of the EGFR 'family' are active. In addition to EGFR, the 'family' consists of HER2, HER3 and HER4, and these are implicated in a number of cancers such as lung, colorectal, head and neck, and pancreatic cancers.

"Theoretically, inhibiting ADAMs should block downstream signalling from all four EGFR family members and thus potentially reduce cancer progression. We are excited that we have seen an effect in this particularly aggressive subgroup of breast cancers but propose that we will see an effect in other cancer settings also," said Dr McGowan.'/>"/>

Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. U.S. Scientists Commit Most Research Fraud: Study
2. Four NYU researchers receive New York Academy of Sciences 2010 Young Scientists awards
3. Scientists Find Way to Boost Good Cholesterol in Mice
4. NIH scientists explore 1510 influenza pandemic and lessons learned
5. Scientists at IRB Barcelona and BSC publish the worlds largest video data bank of proteins
6. NIH scientists unveil mechanisms of immune reconstitution inflammatory syndrome
7. Scientists Use Tarantulas to Explore Human Fear
8. Scientists Say Theyve Made Blood From Skin
9. Hospital for Special Surgery scientists share advances in lupus and related conditions
10. Scientists develop method to keep surgically-removed prostate tissue alive and working for week
11. Scientists turn a new leaf to discover a compound in daffodils that targets brain cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... The Holiday Inn Westbury - Long Island ... Association to donate various items consisting of practical, ... such items.The Association's program is aimed toward helping over ... nursing homes, assisted living facilities and nursing homes. The ... of seniors throughout the Long Island area. The Holiday ...
(Date:11/24/2014)... and Philadelphia, PA (PRWEB) November 24, 2014 ... of care coordination and disease management services to ... chosen to implement Essetteā€™s Medical Management software suite. ... Essette SaaS platform in a program to reduce ... suite includes Population Health Management, Care Management, Utilization ...
(Date:11/23/2014)... iFitDress.com, a well-known wedding dress manufacturer, has unveiled its ... They are now offered at deeply discounted prices, up to ... to Dec. 15. The main purpose of the promotion is ... quality items are ideal options for ladies who are eager ... All its new mint cocktail dresses are very beautiful; they ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 Nearly ... heart attacks, strokes, deep vein thrombosis and other ... a federal multidistrict litigation (MDL) underway in the ... , Court documents updated on November 17th ... (JPML) show the filing of 259 lawsuits against ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 To show thanks ... its new collection of white evening dresses for ... online workers 24/7. , iFitDress.com is a distinguished dress manufacturer, ... and supported by worldwide customers for a very long time. ... place where a customer will be able to buy not ...
Breaking Medicine News(10 mins):Health News:The Holiday Inn Westbury - Long Island gives back to the local Long Island community, and also goes beyond borders to assist those in need during the 2014 Holiday Season 2Health News:The Holiday Inn Westbury - Long Island gives back to the local Long Island community, and also goes beyond borders to assist those in need during the 2014 Holiday Season 3Health News:ReAdmission Solutions, LLC Selects Essette 2Health News:Trendy Long Black Evening Gowns Now Provided By iFitDress.com 2Health News:Testosterone Lawsuits Approach 260 in Illinois Federal Court Litigation, Bernstein Liebhard LLP Reports 2Health News:Testosterone Lawsuits Approach 260 in Illinois Federal Court Litigation, Bernstein Liebhard LLP Reports 3Health News:iFitDress.com: Wonderful White Evening Dresses Now Available 2
... Tobacco-Free,Kids, WASHINGTON, Oct. 2 The following is ... Kids:, The Campaign for Tobacco-Free Kids applauds Tyra ... exposing the ugly truth that,smoking is not only dangerous ... week,s season premiere of "America,s Next Top Model",featured a ...
... Manchester scientists will discuss their research aimed at reducing ... at the National Cancer Research Institute conference in Birmingham ... patients receive radiotherapy as part of their cancer treatment ... causing side effects (toxicity) to the normal tissues and ...
... For the first time, data show a positive ... overall health at birth. Babies born to women with ... to be less likely to need intensive care than ... Inc. (NASDAQ:CBRX) announced today. The data are published in ...
... Angel Flight West (AFW),awarded The Distinguished Pilot award ... Awards on Saturday, September 29. Dr. Irish,completed 18 Angel ... AFW,pilot, he flies people in need whose non-emergency health ... facilities. Dr. Irish, like,all AFW volunteer pilots, donates the ...
... Does your October purchase really make a difference?, ... products to,benefit the breast cancer cause, Y-ME National Breast ... make meaningful,consumer choices to ensure that their money really ... consumers can take to become informed about,pink, promotions so ...
... HILL, N.C., Oct. 2 The U.S. hospital ... vying to get their,therapies on hospital formularies. Among ... time with key physicians and the list of ... companies are working their way into formularies via,specialized ...
Cached Medicine News:Health News:Tobacco-Free Kids Applauds Tyra Banks for Exposing the Ugly Truth About Smoking 2Health News:Cancer researchers seek safe reduction of radiotherapy 2Health News:Vaginal progesterone gel may improve infant outcomes and... 2Health News:Vaginal progesterone gel may improve infant outcomes and... 3Health News:Vaginal progesterone gel may improve infant outcomes and... 4Health News:Angel Flight West Recognizes Colorado Pilots and Supporters at AFW 24th Anniversary Awards 2Health News:National Breast Cancer Awareness Month 2Health News:Equipping your Sales Force to Influence Hospital Formulary Decision-Makers 2
(Date:11/24/2014)... Nov. 24, 2014  Surgical Theater, LLC, announced today ... 24 th opening of Europe,s ... Nazionale "C. Besta." The SuRgical Planner (SRP) and the ... the event for their 3D navigation and augmented reality ... Bederson , Professor and Chair, Department of Neurosurgery at ...
(Date:11/24/2014)... 24, 2014  Pifflers United Chronic and Invisible ... release of results of a study of ActiPatch®, ... self-management of fibromyalgia pain. The results demonstrated that ... very significant clinically meaningful pain reduction can be ... with fibromyalgia used ActiPatch® for 7 days and ...
(Date:11/22/2014)...  Sprout Pharmaceuticals today announced positive preliminary results from a ... flibanserin up to 200 mg at bedtime had no next-day ... 20 th Annual Fall Scientific Meeting of the Sexual ... Miami . The Phase 1 ... Letter and the Formal Dispute Resolution that was filed in ...
Breaking Medicine Technology:Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 2Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 3Pifflers United - "Supporting Anyone Living With Chronic/Invisible Illness" Reports ActiPatch Bioelectronic Therapy Relieves Chronic Pain In Fibromyalgia 2Pifflers United - "Supporting Anyone Living With Chronic/Invisible Illness" Reports ActiPatch Bioelectronic Therapy Relieves Chronic Pain In Fibromyalgia 3Sprout Pharmaceuticals Presents Phase 1 Clinical Trial Data Showing Treatment With Flibanserin Results In No Next-Day Driving Impairment 2Sprout Pharmaceuticals Presents Phase 1 Clinical Trial Data Showing Treatment With Flibanserin Results In No Next-Day Driving Impairment 3
... Chrono-log's wide range of Platelet aggregometers ... to meet particular needs. Single, dual ... with chart recorder outputs or digital ... Chrono-log Optical aggregometers, which measure platelet ...
... a four channel platelet aggregation profiler combined ... in conjunction with Microsoft WindowsTM, the PAP-4CD ... tests, automatic storage of test results, plus ... test modes are available: chromogenic assays, von ...
... is a four channel platelet aggregation profiler ... assays, von Willebrand assay (Ristocetin cofactor), platelet ... also be used for the evaluation and ... channels allow four tests to be run ...
... plus, innovation means 4 on-board measurement ... and im-proved operator ergonomics. This supports ... required for true workload consolidation, leading ... only one analytical platform, one user ...
Medicine Products: