Navigation Links
Scientists identify potential new target for treating triple negative breast cancer
Date:11/16/2010

, but the researchers tested it to see whether inhibiting ADAM and EGFR simultaneously would work synergistically. "We did not observe any additional benefit when we combined the ADAM inhibitor with gefitinib; however, adding gefitinib 72 hours after ADAM inhibitor treatment was more effective than adding both inhibitors simultaneously, although this did not reach statistical significance."

In addition, another, as yet un-named compound that blocks both ADAM10 and ADAM17 resulted in significant effect on a range of TNBC cell lines. "We found that it reduced the growth of these cells by up to 91%," she said. "We have also found that treatment of TNBC cells with this compound reduced their ability to migrate, a process that is vital for the progression of cancer.

"Triple negative breast cancers comprise 10-20% of all breast cancer cases. Women with TNBC tend to present with higher grade, larger tumours, are younger at diagnosis, have a higher incidence of metastases and have a shorter time to recurrence compared to other breast cancer types. One reason for the poor prognosis for this group is the lack of targeted therapies for these women. Having found that an ADAM inhibitor can reduce the proliferation of TNBC cell lines, we hope that ADAMs may be a useful therapeutic target."

The scientists hope that inhibiting ADAMs might also be a possible treatment for other cancers in which members of the EGFR 'family' are active. In addition to EGFR, the 'family' consists of HER2, HER3 and HER4, and these are implicated in a number of cancers such as lung, colorectal, head and neck, and pancreatic cancers.

"Theoretically, inhibiting ADAMs should block downstream signalling from all four EGFR family members and thus potentially reduce cancer progression. We are excited that we have seen an effect in this particularly aggressive subgroup of breast cancers but propose that we will see an effect in other cancer settings also," said Dr McGowan.'/>"/>

Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. U.S. Scientists Commit Most Research Fraud: Study
2. Four NYU researchers receive New York Academy of Sciences 2010 Young Scientists awards
3. Scientists Find Way to Boost Good Cholesterol in Mice
4. NIH scientists explore 1510 influenza pandemic and lessons learned
5. Scientists at IRB Barcelona and BSC publish the worlds largest video data bank of proteins
6. NIH scientists unveil mechanisms of immune reconstitution inflammatory syndrome
7. Scientists Use Tarantulas to Explore Human Fear
8. Scientists Say Theyve Made Blood From Skin
9. Hospital for Special Surgery scientists share advances in lupus and related conditions
10. Scientists develop method to keep surgically-removed prostate tissue alive and working for week
11. Scientists turn a new leaf to discover a compound in daffodils that targets brain cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... (PRWEB) September 23, 2014 Mel Frank, ... about cultivating, growing and harvesting marijuana. He is perhaps ... the field and he’ll be leading a special elective ... am to 5:00 pm at Oaksterdam University ... law, botany and nomenclature, harvesting and manicuring, and identifying ...
(Date:9/23/2014)... that FDG-PET technology is less accurate in diagnosing ... infections like histoplasmosis or tuberculosis are common. ... lead to unnecessary tests and surgeries for patients, ... Histoplasmosis and other fungal diseases are linked to ... and are found in soils. , The study ...
(Date:9/23/2014)... San Diego, CA (PRWEB) September 23, 2014 ... website daily regarding all the latest information from the ... announced on September 5, that its Private Label Jalapeno ... glass and small stones. Publix Jalapeno Bagels ... in the bakery department. , Taking into consideration ...
(Date:9/23/2014)... 2014 (HealthDay News) -- A test used to diagnose lung ... certain lung infections are more common, a new analysis says. ... through the use of what,s known as functional imaging. For ... is used, according to the study authors. Cancerous tumors ... parts of the lungs that don,t have cancer, according to ...
(Date:9/23/2014)... 23, 2014 Grinnell Mutual seeks ... projects in the Midwest. Working Together Making It ... non-profit organizations with projects positively impacting their communities. ... marketplace make their communities a better places,” said ... Community Relations Barb Baker. “Their leadership—as coaches, as ...
Breaking Medicine News(10 mins):Health News:Special Elective Course Added to Oaksterdam University Schedule; Unique Opportunity to Learn From the “Godfather of Cannabis” Mel Frank on September 27, 2014 2Health News:Study questions accuracy of lung cancer screens in some geographic regions 2Health News:Publix Private Label Jalapeno Bagels Recalled: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:Lung Infections May Hamper Ability to Detect Lung Cancer 2Health News:Grinnell Mutual Invites Submissions for Innovative, Collaborative Local Projects in Its Second Annual Working Together Making It Better Promotion 2
... with improved survival odds, , SUNDAY, June 21 (HealthDay News) ... are more likely to survive these days than they would ... doctors are trying to puzzle out why heart attacks have ... doing right, and how to keep that trend headed in ...
... Implantable Cardioverter Defibrillator (ICD) have an ongoing risk of ... driving a car. Driving restrictions are imposed making ... consensus statement with recommendations for drivers with ICD,s was ... meeting, in Berlin, Germany on Sunday 21 June. ...
... approach would have the tremendous advantages of enhancing patient ... health staff to focus on medical emergencies," urged Professor ... and official spokesperson of the European Society of Cardiology ... advantage of being more cost effective for health care ...
... devastating to frail elderly and disabled Ohioans , ... Nursing Care Coalition, consisting of the three organizations representing ... than 80,000 frail elderly and disabled Ohioans, today expressed ... announced late Friday. , , "While we respect ...
... makes children fat , FRIDAY, June 19 (HealthDay News) ... fat, nor does living near a supermarket stocked with ... shows. , The study by Indiana University-Purdue University Indianapolis ... 60,000 children aged 3 to 18. They compared the ...
... that men shouldn,t take them with just this in mind ... such as aspirin and ibuprofen might help men avoid prostate ... caution men not to self-dose or to take more than ... can result. , "Our data suggest if men are taking ...
Cached Medicine News:Health News:Heart Attacks Less Often Fatal Today 2Health News:Heart Attacks Less Often Fatal Today 3Health News:Implanted defibrillators: New recommendations for drivers with ICDs 2Health News:EUROPACE raises remote monitoring profile 2Health News:EUROPACE raises remote monitoring profile 3Health News:Does Location Affect Kids' Weight? 2Health News:Painkillers May Be Good for the Prostate 2Health News:Painkillers May Be Good for the Prostate 3
(Date:9/23/2014)... , Sept. 23, 2014  Hill-Rom (NYSE: ... Providence Health ( Renton, WA ), the ... expands the companies, existing relationship as Hill-Rom now becomes ... Bariatric capital bed frame and surface products. ... systems in the U.S.  It operates 34 hospitals, 475 ...
(Date:9/23/2014)... Sept. 23, 2014  MEDIMETRIKS PHARMACEUTICALS today announced ... Resnick have been elected to Medimetriks, Board ... Mr. Lary, who will serve on Medimetriks, Audit ... experience to the Company.  Mr. Lary is currently ... a leading institutional investment firm.  Mr. Lary is ...
(Date:9/23/2014)... Sept. 23, 2014   COTA, Inc. today ... $7 million Series A funding round led by Horizon ... is the first big data platform designed by practicing ... analysis for cancer care in support of healthcare,s new ... to expand development of the COTA platform, hire biostatisticians, ...
Breaking Medicine Technology:Hill-Rom Announces Seven-Year, Sole-Source Contract with Providence Health 2Medimetriks Pharmaceuticals, Inc. Welcomes Independent Directors Andrew Lary and William Resnick to its Board of Directors 2COTA Closes $3.7M of Planned $7M Series A Funding Round to Transform Cancer Outcomes and Reimbursement 2COTA Closes $3.7M of Planned $7M Series A Funding Round to Transform Cancer Outcomes and Reimbursement 3COTA Closes $3.7M of Planned $7M Series A Funding Round to Transform Cancer Outcomes and Reimbursement 4
... MARINO, Calif. March 25, 2011 VG Energy, ... VRAL ), announced today that it ... to verify lab results on a large scale for the development ... VG Energy has developed proprietary technology, with results ...
... Ltd. (Nasdaq: SVA ), a leading provider ... Weidong Yin, President and CEO, and Ms. Helen Yang, ... UBS Greater China Healthcare Corporate Day.  The conference will ... March 28th to March 29.  The Sinovac team will ...
Cached Medicine Technology:VG Energy Contracts BioProcess Algae To Verify "Lipid Trigger" Results For Commercial Biofuels Production 2VG Energy Contracts BioProcess Algae To Verify "Lipid Trigger" Results For Commercial Biofuels Production 3VG Energy Contracts BioProcess Algae To Verify "Lipid Trigger" Results For Commercial Biofuels Production 4Sinovac Participates in UBS Greater China Healthcare Corporate Day 2
... 210, Carl Zeiss has created a surgical microscope ... for ophthalmic surgery. Its wide range of uses ... and it offers new functions to improve depth ... integrated assistant's microscope the OPMI VISU 210 is ...
Blood grouping tubes are available in two formulations, ACD-A, ACD-B or with a CPDA solution. Blood grouping tubes are for blood grouping determinations and also for cell preservation....
MONOJECT Brown Stopper...
BD Vacutainer® PST™ Tubes contain spray-coated lithium heparin and a gel for plasma separation. They are used for plasma determinations in chemistry....
Medicine Products: