Navigation Links
Scientists identify possible drug target for acute pancreatitis
Date:5/31/2012

Bethesda, MDScientists from the Universities of Illinois and California have found that the inflammatory protein interleukin-6 (IL-6) plays a pivotal role in the duration of acute pancreatitis in animal models with this condition. Their report, in the June 2012 issue of the Journal of Leukocyte Biology, describes experiments in lean and obese mice that identify the presence of high IL-6 as one of the reasons why the disease is more devastating in obese people.

"The study helps to understand why acute pancreatitis is more prolonged in obese subjects," said Giamila Fantuzzi, Ph.D., the senior researcher of this work, from the Department of Kinesiology and Nutrition at the University of Illinois at Chicago. "Our data indicate that IL-6 participates in prolonging inflammation in obese mice with acute pancreatitis, but also show that this inflammatory mediator is not the most important factor in determining the severity of the acute response."

To make this discovery, researchers used lean and obese mice that do and do not produce IL-6. They induced acute pancreatitis in all mice and studied them at different times of the disease. Both groups of the lean mice developed mild disease and then promptly recovered. Both sets of obese mice developed more severe disease at its onset. For the obese mice that did not produce IL-6, the course of the disease was much shorter than in the obese mice that did produce IL-6. It is also important to note that obesity leads to elevated levels of IL-6 and other inflammatory proteins.

"There is an increasing awareness that obesity and inflammation are connected," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Not only does this new report demonstrate an important set of interactions between obesity, pancreatitis, and inflammation, but it also identifies the inflammatory pathway, IL-6, which could represent an important new therapeutic target in these settings."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... Sunrise, FL (PRWEB) March 05, 2015 ... appear at this week’s Arnold Sports Festival and ... March 5-8. Metabolic Nutrition will host a display ... its all-new pre-workout E.S.P. and its highly-popular, class-leading fat ... free shaker cups, unique recipes that utilize its top-of-the-line ...
(Date:3/5/2015)... Think it’s tough to get kids to ... them to brush their teeth. That’s a finding from a ... Delta Dental(1) in conjunction with National Parenting Month in March. ... kids to brush their teeth is one of the most ... higher than getting children to eat vegetables regularly (42 percent) ...
(Date:3/5/2015)... DE (PRWEB) March 05, 2015 The ... false weight loss promises is alarming, with more and ... products without an actual prescription, making it easy for ... that simply take their money and endanger their health. ... questions before purchasing prescription online diet pills: , 1.    Where ...
(Date:3/5/2015)... The MTC 5-day Fundamental Implantology Course ... from a variety of dental disciplines, to offer implant ... "From the onset we wanted this course to be ... to the excellence of the lecturers and the sheer ... more than satisfied our aims." , Unlike large-scale ...
(Date:3/5/2015)... Plains, NY (PRWEB) March 05, 2015 Hope ... New York Sporting Clay Shoot to be held at Beretta ... May 15, 2015. All proceeds from the event will benefit ... a sense of self, restoring the family unit, and restoring ... The event will honor our nation’s heroes through a day ...
Breaking Medicine News(10 mins):Health News:Metabolic Nutrition Exhibiting at 2015 Arnold Sports Festival and Fitness EXPO This Week 2Health News:Delta Dental Survey Says Parents Have Harder Time Getting Kids to Brush than to Eat Vegetables 2Health News:Delta Dental Survey Says Parents Have Harder Time Getting Kids to Brush than to Eat Vegetables 3Health News:Diet Doc Announces Four Simple Questions that Dieters Must Ask Prior to Purchasing Online Diet Pills 2Health News:Diet Doc Announces Four Simple Questions that Dieters Must Ask Prior to Purchasing Online Diet Pills 3Health News:MIS Global Training Center (MTC) Launches its Fundamental Implantology Course for Doctors - with a Difference 2Health News:Hope For The Warriors Announces New York Clay Shoot to Benefit Military Families 2
... by the National Human Genome Research Institute (NHGRI), has ... shows promise in laboratory studies for treating a fatal ... ,These drugs belong to a class of farnesyltransferase inhibitors ... myeloid leukemia, neurofibromatosis and other conditions. It could also ...
... Brisk walks or running may reduce the risk of ovarian cancer, ... may reduce the risk of some other forms of cancer. ... a 70 % reduction in the risk of development of ovarian ... colon cancer was also less frequent among those who exercised. ...
... behaviors, like over speeding, more in company of same ... sex. ,The study was published on-line edition of ... ,The findings indicate that teen risky driving increases in ... But more important, the finding should remind teens-and the ...
... from University of Pennsylvania had identified a brain chemical ... abuse. The chemical called orexin is also involved in ... ,Research showed that the activation of ... that controls many vital functions such as eating, body ...
... couples trying to conceive that is, one in every six ... a problem with conception. ,With this being the clinical ... is increasing day by day. // In spite of ... to physical, mental and psychological trauma. Anxiety of patients regarding ...
... by AUT Professor of Nutrition Elaine Rush states that ... sugar as well as caffeine contributes to obesity. // ... containing sugar, added caffeine and guarana (which also contains ... more rapidly than lemonade. "These results could have huge ...
Cached Medicine News:Health News:Brain Chemical Identified For Drug Dependent Behavior 2Health News:Will anxiety regarding fertility treatment affect the chances of conception? 2Health News:Obesity Can Be Caused By Consumption Of Energy Drinks 2
(Date:3/5/2015)... 5, 2015  Sanomedics, Inc. (OTC: SIMH, SIMHD) ("Sanomedics" ... on developing, manufacturing, and acquiring cutting-edge technology, products and ... will be exhibiting at booth # 709 at the ... (NAPNAP) taking place on March 11-13, 2015 at Caesars ... The 36 th annual NAPNAP ...
(Date:3/5/2015)... , March 5, 2015   AMC ... management solutions recognized for improving the effectiveness and ... that Robert Anazagasty and Jared ... serve as Vice President, Strategic Client Development, and ... These additions support AMC Health,s commitment to accelerating ...
(Date:3/5/2015)...  Celsion Corporation (NASDAQ: CLSN ) ... conference call to discuss year-end 2014 financial results ... for ThermoDox®, its proprietary heat-activated liposomal encapsulation of ... and TheraSilence™, in immunotherapy and RNA delivery at ... To participate in the call, interested parties may ...
Breaking Medicine Technology:Sanomedics to Showcase the Caregiver at National Association of Pediatric Nurse Practitioners Conference 2Sanomedics to Showcase the Caregiver at National Association of Pediatric Nurse Practitioners Conference 3AMC Health Bolsters Sales Team with Robert Anazagasty and Jared Wilstead 2AMC Health Bolsters Sales Team with Robert Anazagasty and Jared Wilstead 3Celsion Corporation to Hold Year-End 2014 Financial Results Conference Call on Thursday, March 12, 2015 2
... WORCESTER, Mass. and TORONTO, Nov. 21, 2011 Generex ... that its wholly-owned subsidiary, Antigen Express, Inc. ( www.antigenexpress.com ... its study of a novel Ii-Key Hybrid-based HER-2/neu Peptide ... the 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium ...
... Calif., Nov. 21, 2011  BARRX Medical Inc., a leader ... with endoscopy to remove precancerous tissue from the gastrointestinal ... agreement to be acquired by Covidien.  Covidien is a ... leader in advanced energy-based devices.  Covidien ...
Cached Medicine Technology:Generex Subsidiary Antigen Express to Present AE37 Cancer Vaccine Phase 2 Clinical Data at 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium 2Generex Subsidiary Antigen Express to Present AE37 Cancer Vaccine Phase 2 Clinical Data at 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium 3Generex Subsidiary Antigen Express to Present AE37 Cancer Vaccine Phase 2 Clinical Data at 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium 4Generex Subsidiary Antigen Express to Present AE37 Cancer Vaccine Phase 2 Clinical Data at 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium 5BARRX Medical, Inc. Announces Definitive Agreement to be Acquired by Covidien 2BARRX Medical, Inc. Announces Definitive Agreement to be Acquired by Covidien 3
The XTRI method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of triglycerides in serum and plasma....
For the quantitative in vitro determination of Triglycerides in serum and plasma....
CK-MB Control...
The CK method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of creatine kinase activity in serum and plasma...
Medicine Products: