Navigation Links
Scientists identify possible drug target for acute pancreatitis
Date:5/31/2012

Bethesda, MDScientists from the Universities of Illinois and California have found that the inflammatory protein interleukin-6 (IL-6) plays a pivotal role in the duration of acute pancreatitis in animal models with this condition. Their report, in the June 2012 issue of the Journal of Leukocyte Biology, describes experiments in lean and obese mice that identify the presence of high IL-6 as one of the reasons why the disease is more devastating in obese people.

"The study helps to understand why acute pancreatitis is more prolonged in obese subjects," said Giamila Fantuzzi, Ph.D., the senior researcher of this work, from the Department of Kinesiology and Nutrition at the University of Illinois at Chicago. "Our data indicate that IL-6 participates in prolonging inflammation in obese mice with acute pancreatitis, but also show that this inflammatory mediator is not the most important factor in determining the severity of the acute response."

To make this discovery, researchers used lean and obese mice that do and do not produce IL-6. They induced acute pancreatitis in all mice and studied them at different times of the disease. Both groups of the lean mice developed mild disease and then promptly recovered. Both sets of obese mice developed more severe disease at its onset. For the obese mice that did not produce IL-6, the course of the disease was much shorter than in the obese mice that did produce IL-6. It is also important to note that obesity leads to elevated levels of IL-6 and other inflammatory proteins.

"There is an increasing awareness that obesity and inflammation are connected," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "Not only does this new report demonstrate an important set of interactions between obesity, pancreatitis, and inflammation, but it also identifies the inflammatory pathway, IL-6, which could represent an important new therapeutic target in these settings."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... 20, 2017 , ... Vitamin Well has launched two new ... have been produced in collaboration with Zlatan Ibrahimovic and have been developed to ... a successful launch in Sweden last year, the next generation sports drinks VW+001 ...
(Date:1/20/2017)... , ... January 20, 2017 , ... ... ® Oscillating Positive Expiratory Pressure (OPEP) device, was featured in a study indicating ... Pursley, MEd, RRT-ACCS, FAARC, “Analysis of Three Oscillating Positive Expiratory Pressure Devices ...
(Date:1/20/2017)... ... ... “God's Miracle Man: Against All Odds”: an inspiring affirmation of God’s work. “God's ... Tucker, son of Minister Delores Pinnock and a Jamaican native who lives in Kingston ... sitting up in bed, I felt a pounding headache. It was like a drum ...
(Date:1/19/2017)... ... ... With the cold weather here, many people will have to clear snow with snow blowers ... of snow, but they can be dangerous when used incorrectly. That’s why Amica Insurance ... proper use of snow blowers:, , When removing wet snow or ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Cosmetic Town, an ... surgery procedures in order to make it easier for their readers to get the ... body they impact as well as the techniques used on those particular areas. , ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , Jan. 19, 2017 Conference Call and Webcast to ... ) today announced it will release results for the fourth quarter ... ... host a conference call at 4:30 PM ET on Wednesday, February ... full year 2016 financial results and other corporate activities. To participate ...
(Date:1/19/2017)... 2017 This report on the opioid induced ... of the global market. Large number of chronic pain ... constipation is a major side effect of consumption of ... targeted therapy has been prescribed to treat opioid induced ... medicines, and growing awareness about the therapy are the ...
(Date:1/19/2017)...  Stealth BioTherapeutics Inc. ( Stealth ), a clinical-stage ... announced new additions to its senior leadership team: ... and Daniel Geffken as interim Chief Financial ... , Pharm.D. has been promoted to Chief Clinical Development ... Doug and Daniel to our management team, as both ...
Breaking Medicine Technology: