Navigation Links
Scientists identify overactive genes in aggressive breast cancers
Date:6/1/2011

their surfaces. They resemble stem cells, as they constantly renew themselves and make tumors likely to spread to distant organs.

As a result, Polyak and colleagues believe that new treatments aimed at specifically knocking out these CD44+CD24- cells with activated Jak2/Stat3 signaling could be useful in combating triple-negative cancers and potentially other tumors that contain these cells.

The investigators surveyed genes present in CD44+CD24- cells and found 1,576 genes that differed from those in other, more differentiated epithelial cancer cells within tumors. Additional experiments assessing the viability of CD44+CD24- cells when each of these genes was inhibited individually narrowed the field to 15 genes that were required for their growth and thus looked like promising targets for selective drugs. These 15 genes were linked to the overactive Jak2/Stat3 pathway, which in turn was triggered by a growth factor signal, interleukin-6, or IL-6.

When the activity of several of those genes was blocked in CD44+/CD24- tumor cells, the level of Stat3 signaling was reduced and cell growth was suppressed, the researchers said.

Polyak said that inhibitor drugs exist for five of the genes identified in the CD44+CD24- cell network, and two of those drugs are currently in advanced clinical testing.

Nancy Lin, MD, a Dana-Farber oncologist who will lead the clinical trial of a Jak2/Stat3 inhibitor in breast cancer patients, said women who volunteer for the trial will be tested to determine whether the pathway is abnormally activated in their cancer. Those who test positive will be candidates for treatment with the drug. According to Lin, the abnormal pathway is expected to be found in 50 to 60 percent of patients with triple-negative cancers.


'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists identify overactive genes in aggressive breast cancers
(Date:7/11/2014)... Microbiology testing is a highly dynamic ... which is expected to pose the biggest challenge to ... its growth to the ongoing spread of AIDS – ... a major factor leading to the upsurge of opportunistic ... a broader availability of immunosuppressants, among others. , ...
(Date:7/11/2014)... 11, 2014 As part of ... Liebhard LLP has been closely monitoring the ongoing ... (FDA) Obstetrics and Gynecology Devices Panel, which ... the cancer risks associated with the use of ... to a report published by Dow Jones Business ...
(Date:7/11/2014)... The report, “Specialty Synthetic Fibers ... Geography - 2018,” defines and segments the specialty ... analysis and forecast of the volumes and values ... aramids, meta aramids, UHMW Polyethylene, carbon fiber, partially ... PBI fiber, PBO fiber, and liquid crystal polymer ...
(Date:7/11/2014)... 2014 The Europe Well Intervention Market report ... with analysis and revenue forecast. The well intervention services market ... in 2013 to $3.4 billion by 2018, at a CAGR ... TOC of the Europe Well Intervention Market report, to get ... a glimpse of the segmentation in the Europe well intervention ...
(Date:7/11/2014)... 11, 2014 Datalogic brings a new ... sanitation hospital wide. With their new Gryphon GD4400 ... disease, like the devastating MRSA, which claimed 5,500 lives, ... GD4400-HC 2D and the Gryphon GM4400-HC 2D readers ... can even read barcodes off of troublesome LCD monitors, ...
Breaking Medicine News(10 mins):Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 2Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 3Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 2Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 3Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 4Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 2Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 4Health News:Europe Well Intervention Services Market is Expected to Reach $3.4 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:Europe Well Intervention Services Market is Expected to Reach $3.4 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 2Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 3
... Health and Safety Products Company, Kidz-Med, Inc. takes special notice ... Kidz-Med, Inc. along with its parent company, American Scientific Resources, ... role models for all families. , , In 1994, ... Sunday of each July, as a national day of commemoration, ...
... exposure during pregnancy to miniscule levels of carbon monoxide damages ... The journal BMC (BioMed Central) Neuroscience published ... "We expected the placenta to protect fetuses from the ... Edmond, professor emeritus of biological chemistry at the David Geffen ...
... Evanston, Ill., June 25 Lenox Hill Heart and ... Inc. (Mentice) partnered to coordinate the 1st trans-septal specific ... the Mentice VIST(TM) endovascular simulator to enhance the training ... , , The two-day course included didactic presentations, ...
... Reduce Access to Care for Dying Americans , , ... the country sent a letter to President Barack Obama urging him ... 1, 2009. , , The cuts threaten to ... patients and their family caregivers receive from hospice providers each year. ...
... , Funding supports multiple commercial, emerging and pilot projects ... for Stem Cell & Regenerative Medicine (CSCRM), comprised of ... (CC), University Hospitals (UH), and Athersys, Inc. has received ... Research Commercialization Program. The funding will help support new ...
... to Millennium Research Group (MRG), the global authority ... procedure adoption will accelerate over the next five ... deep vein thrombosis (DVT). Although the ATTRACT (Acute ... trial, which will compare catheter-directed thrombolysis (CDT) to ...
Cached Medicine News:Health News:Parents' Day is Coming - Kidz-Med Celebrates the Role of Parents 2Health News:Tiny levels of carbon monoxide damage fetal brain 2Health News:Lenox Hill Heart and Vascular Institute of New York and Mentice, Inc. Announce the Successful Completion of Their 1st Trans-septal Cardiac Catheterization Training Course: A Comprehensive Hands-On Tutorial with Certification on June 12th and 13th 2009 in 2Health News:Lenox Hill Heart and Vascular Institute of New York and Mentice, Inc. Announce the Successful Completion of Their 1st Trans-septal Cardiac Catheterization Training Course: A Comprehensive Hands-On Tutorial with Certification on June 12th and 13th 2009 in 3Health News:Hospice Community Urges President Obama to Stop Funding Cuts 2Health News:Case Western Reserve University Receives $5M From Third Frontier Commission for the Center for Stem Cell & Regenerative Medicine 2Health News:Case Western Reserve University Receives $5M From Third Frontier Commission for the Center for Stem Cell & Regenerative Medicine 3Health News:Case Western Reserve University Receives $5M From Third Frontier Commission for the Center for Stem Cell & Regenerative Medicine 4Health News:Case Western Reserve University Receives $5M From Third Frontier Commission for the Center for Stem Cell & Regenerative Medicine 5Health News:Pharmacomechanical Thrombectomy Procedure Adoption to Accelerate Due to More Aggressive Treatment of Deep Vein Thrombosis, According to Millennium Research Group 2Health News:Pharmacomechanical Thrombectomy Procedure Adoption to Accelerate Due to More Aggressive Treatment of Deep Vein Thrombosis, According to Millennium Research Group 3
(Date:7/11/2014)... Research and Markets has announced the addition ... Industry Report 2014" report to their offering. ... And Chinese Medical X-Ray Film Industry Report 2014 is ... of the Global medical X-ray film industry with a ... a basic overview of the industry including definitions, classifications, ...
(Date:7/11/2014)... According to a new ... Material, Application (Healthcare, Homeland security, Industrial application, Nuclear ... Hand-Held Instruments, Fixed, and Installed Instruments) & Geography ... by MarketsandMarkets, the Scintillator Market is expected to ... to 2020, and reach $479.16 Million in 2020. ...
(Date:7/11/2014)... -- Research and Markets  has announced the addition ... report to their offering. ... hollow needle commonly used with a syringe to inject ... from it. A hypodermic needle is used for rapid ... be ingested. Hypodermic needles are broadly classified into non-safety ...
Breaking Medicine Technology:Global and Chinese Medical X-ray Film Industry Report 2014 2Scintillator Market will be worth $479.16 Million by 2020 2Scintillator Market will be worth $479.16 Million by 2020 3Scintillator Market will be worth $479.16 Million by 2020 4Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3
... Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX ), ... human disease, announced today that Dr. Roy Fleischmann from ... presenting data from Lexicon,s LX2931 Phase 2 ... American College of Rheumatology on Wednesday, November 9, 2011 ...
... Nov. 8, 2011 Mesa Laboratories, Inc. (NASDAQ: ... declared a regular quarterly dividend of $.13 per share of ... dividend will be payable December 15, 2011, to shareholders of ... in 1984 Mesa Labs has maintained strong cash positions and ...
Cached Medicine Technology:LX2931 Phase 2 Data to be Presented at the American College of Rheumatology Conference 2LX2931 Phase 2 Data to be Presented at the American College of Rheumatology Conference 3
The Natural-Knee Family is a complete range of interchangeable, anatomically-designed implants with over 14 years of proven clinical results....
Maximum contact. Minimum wear. Outstanding results....
... tricompartmental total knee prosthesis stems from many ... design and manufacturing technologies have been used ... as well as a favorable pressure distribution ... keep wear to a minimum. The inherent ...
...
Medicine Products: