Navigation Links
Scientists identify overactive genes in aggressive breast cancers
Date:6/1/2011

BOSTONScientists at Dana-Farber Cancer Institute have identified an overactive network of growth-spurring genes that drive stem-like breast cancer cells enriched in triple-negative breast tumors, a typically aggressive cancer that is highly resistant to current therapies.

Kornelia Polyak, MD, PhD, a breast cancer geneticist at Dana-Farber, and colleagues found that a large proportion of cells within these tumors showed elevated activity in a network of genes called the Jak2/Stat3 pathway. Experiments have demonstrated that a drug specifically aimed to block this pathway halted the growth of such tumors in mice. The report will be published online June 1 by The Journal of Clinical Investigation in advance of its July print issue.

Polyak called the strategy very promising. "The discovery of these targets will rapidly lead to clinical trials with the hope of achieving one of the first specific therapies for triple-negative breast cancers," said Polyak, senior author of the findings that was submitted by a large collaboration of scientists.

Jak2/Stat3 inhibitors are already in advanced phases of clinical testing for certain blood cancers that are driven by the Jak2/Stat3 pathway. Polyak noted that because these inhibitors have already been tested in humans and appear to be relatively non-toxic, it should be possible to begin testing them in breast cancer patients soon.

Triple-negative breast cancers are characterized by a lack of estrogen, progesterone, and HER2 receptors, which makes them unresponsive to targeted treatments that block those receptors. These tumors, also termed "basal-like," make up an estimated 15 to 20 percent of breast cancers and tend to occur in younger women, those with BRCA1 gene mutations, and black women.

Polyak previously found that triple-negative tumors typically contain a large number of "stem-like" breast cancer cells, labeled CD44+CD24- cells, referring to identifying markers on
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists identify overactive genes in aggressive breast cancers
(Date:9/20/2014)... MarijuanaDoctors.com recently returned to New ... PAIN Week conference that was held at the ... Las Vegas from September 2nd to September 6th. ... in the hopes of educating physicians in regards ... tool to treat chronic Pain, MarijuanaDoctors.com accomplished goals ...
(Date:9/19/2014)... Nearly 780 Risperdal lawsuits are moving ... a meeting took place to discuss the next steps ... the court’s mass tort program. Attorneys for the plaintiffs ... at the Complex Litigation Center in Philadelphia’s City Hall ... The Risperdal lawsuits filed against Johnson & Johnson and ...
(Date:9/19/2014)... (Washington, DC) (PRWEB) September 19, 2014 ... to inflate sales of brand drugs among patients with ... D, according to a new report from ... the Inspector General (OIG). Federal anti-kickback laws prohibit suppliers ... are subsidized by the federal government. , The report ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 Unbound , ... to families in regions of the Philippines being affected by ... More than 1,060 families evacuated to the nearest public schools ... brought heavy rain and gusty winds to portions of the ... heavy flooding. Some homes filled with more than 10 feet ...
(Date:9/19/2014)... 19, 2014 (HealthDay News) -- As kids transition from ... of cyberbullies, according to a recent study. ... through 8 found that verbal and physical bullying declines ... bullying intervention and prevention strategies must address all types ... boys and girls, the researchers said. The study was ...
Breaking Medicine News(10 mins):Health News:MarijuanaDoctors.com Experiences Unprecedented Support and Growth at Pain Week 2014 2Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 2Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 3Health News:Risperdal Lawsuits Move Forward As Attorneys Meet To Discuss Litigation, Reports Wright & Schulte LLC 4Health News:PCMA: New OIG Report Cites Drug Manufacturer“Copay Coupon” Use in Medicare Part D 2Health News:Double Threat in Philippines Displaces Thousands of Unbound Families 2Health News: Cyberbullying Seems to Ramp Up in Middle School 2
... , RESEARCH TRIANGLE PARK, N.C., Sept. 21 ... standards for funding accredited, continuing medical education (CME) for healthcare ... Starting in 2010, GSK will raise the bar and ... to close gaps in patient care, and that demonstrate support ...
... ... TCO by Streamlining IT Audit Processes, Harmonizing Controls with Policy Requirements, and Providing Greater IT ... ... , , ,News Facts:, , ,A typical organization spends 30-50% more on compliance and IT ...
... , LOS ANGELES, Sept. 21 ... nationally as the "Dean of DUI Attorneys", claims that many citizens ... alcohol (DUI) are actually innocent. Their crime: diabetes. , ... Drunk Driving Defense , claims that the symptoms of a ...
... , , , ... economic downturn and reduction in funding for early stage projects ... across major therapeutic segments in the short-to-medium term. However, due ... and biotechnology companies will invest in in-house capabilities to conduct ...
... may suffer from dementia , MONDAY, Sept. 21 (HealthDay ... a rapid pace, and by next year 35.6 million people ... percent increase since 2005, a new report predicts. , ... 65.7 million in 2030 and 115.4 million in 2050, ...
... , , SAN JOSE, Calif., ... of Motorola, Inc. (NYSE: MOT ), ... partner, has deployed its 802.11n wireless LAN (WLAN) solution ... located in Ludington, Mich. , , Motorola,s innovative ...
Cached Medicine News:Health News:GSK Limits Medical Education Funding to Independent Programs With Highest Impact on Patient Care 2Health News:GSK Limits Medical Education Funding to Independent Programs With Highest Impact on Patient Care 3Health News:Lumension Unveils Enhanced Compliance and IT Risk Management Solution that Enables Organizations to Continuously Monitor Compliance and IT Risk Posture while Reducing the Overall Cost of Compliance 2Health News:Lumension Unveils Enhanced Compliance and IT Risk Management Solution that Enables Organizations to Continuously Monitor Compliance and IT Risk Posture while Reducing the Overall Cost of Compliance 3Health News:Lumension Unveils Enhanced Compliance and IT Risk Management Solution that Enables Organizations to Continuously Monitor Compliance and IT Risk Posture while Reducing the Overall Cost of Compliance 4Health News:Lumension Unveils Enhanced Compliance and IT Risk Management Solution that Enables Organizations to Continuously Monitor Compliance and IT Risk Posture while Reducing the Overall Cost of Compliance 5Health News:Lumension Unveils Enhanced Compliance and IT Risk Management Solution that Enables Organizations to Continuously Monitor Compliance and IT Risk Posture while Reducing the Overall Cost of Compliance 6Health News:Lumension Unveils Enhanced Compliance and IT Risk Management Solution that Enables Organizations to Continuously Monitor Compliance and IT Risk Posture while Reducing the Overall Cost of Compliance 7Health News:Los Angeles DUI Attorney Claims Diabetics Often Falsely Convicted of Drunk Driving 2Health News:Frost & Sullivan: Key Therapeutic Areas to Remain Strongest Drivers of CRO Revenue Growth in the United States 2Health News:Frost & Sullivan: Key Therapeutic Areas to Remain Strongest Drivers of CRO Revenue Growth in the United States 3Health News:Alzheimer's Soars, Global Focus Needed: Study 2Health News:Alzheimer's Soars, Global Focus Needed: Study 3Health News:Motorola's 802.11n Wireless LAN Solution Improves Patient Care and Wireless Security at Memorial Medical Center of Western Michigan 2Health News:Motorola's 802.11n Wireless LAN Solution Improves Patient Care and Wireless Security at Memorial Medical Center of Western Michigan 3Health News:Motorola's 802.11n Wireless LAN Solution Improves Patient Care and Wireless Security at Memorial Medical Center of Western Michigan 4Health News:Motorola's 802.11n Wireless LAN Solution Improves Patient Care and Wireless Security at Memorial Medical Center of Western Michigan 5
(Date:9/19/2014)... 2014 Today, iHealth Lab Inc. announced it has ... for its first institutional round of funding. The strategic ... reach, accelerate growth and innovation, and invest in additional ... Xiaomi Ventures will join iHealth,s board of directors, bringing ... ecommerce. "We are very pleased to have ...
(Date:9/19/2014)... , September 19, 2014 ... has announced the addition of the ... to their offering.      (Logo: ... been broadly classified into wide categories based ... for the treatment of different gynecological conditions ...
(Date:9/19/2014)... Ill. , Sept. 19, 2014  The board ... ) declared a quarterly cash dividend of $0.42 per ... Nov. 17, 2014 to stockholders of record at the ... About AbbVie AbbVie is a global, research-based biopharmaceutical company ... mission is to use its expertise, dedicated people and ...
Breaking Medicine Technology:iHealth Raises $25 Million to Fuel Growth and Global Market Share 2Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 2Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 3
... 2011 Reportlinker.com announces that a new market ... Global Microscopes Industry ... the worldwide markets for Microscopes in US$ Million ... Microscopes, and Scanning Probe Microscopes. The report also ...
... StemCyte, Inc. announces the launch of www.cordbloodtv.com , ... offers this comprehensive educational tool that allows audiences worldwide ... blood banking options and the latest in medical research ... "StemCyte is pleased to offer our worldwide ...
Cached Medicine Technology:Reportlinker Adds Global Microscopes Industry 2Reportlinker Adds Global Microscopes Industry 3Reportlinker Adds Global Microscopes Industry 4Reportlinker Adds Global Microscopes Industry 5Reportlinker Adds Global Microscopes Industry 6Reportlinker Adds Global Microscopes Industry 7Reportlinker Adds Global Microscopes Industry 8Reportlinker Adds Global Microscopes Industry 9Reportlinker Adds Global Microscopes Industry 10Reportlinker Adds Global Microscopes Industry 11Reportlinker Adds Global Microscopes Industry 12Reportlinker Adds Global Microscopes Industry 13Reportlinker Adds Global Microscopes Industry 14Reportlinker Adds Global Microscopes Industry 15Reportlinker Adds Global Microscopes Industry 16Reportlinker Adds Global Microscopes Industry 17Reportlinker Adds Global Microscopes Industry 18Reportlinker Adds Global Microscopes Industry 19Reportlinker Adds Global Microscopes Industry 20Reportlinker Adds Global Microscopes Industry 21Reportlinker Adds Global Microscopes Industry 22StemCyte Launches CordBloodTV 2
Ideal for lower abdominal procedures. Comes with a left side separating zipper....
Female High Waist Briefs...
Provides upper and lower arm support. Extends to the lower arm and across the shoulders. Has two columns of hook & eye closure for added adjustability....
Provides upper and lower arm and flank support. Extends to the wrist and over the full upper back. Has a thin strap above the breast and a 3 waistband for a secure, comfortable fit. Made of soft span...
Medicine Products: