Navigation Links
Scientists identify order of mutations that lead to cancer
Date:6/29/2011

PHILADELPHIA Scientists have begun to reveal the order of the genetic aberrations in individual cancers in a finding they say is key to early diagnosis and personalized medicine.

"We know that each cancer is a collection of genetic malfunctions," said Raymond Cho, Ph.D., an assistant clinical professor in the department of dermatology at the University of California, San Francisco (UCSF). "We now show it is possible to determine which changes happen earlier and which ones happen further down the road, even in a single cancer."

Cho and colleagues reported the findings in Cancer Discovery, the newest journal of the American Association for Cancer Research. He said the work was the result of collaboration among UCSF, the Oregon Health & Science University, the University of California at Berkley and the Samsung Advanced Institute of Technology.

The researchers focused on TP53, a known oncogene present in cutaneous squamous cell carcinomas and serous ovarian adenocarcinomas. By examining how additional copies of the mutant oncogene accumulated, they found that complex changes in TP53 occurred earlier in most cases, rather than later, as had been previously believed.

According to the study, the ability to identify the actual sequence of mutations will help scientists to determine which mutations lead to precancerous lesions and which produce invasive carcinomas.

"Although cancers carry many mutations, the ones that always happen earliest set the stage for additional abnormalities," said Cho.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Scientists discover new molecular pathway involved in wound-healing and temperature sensation
2. Neuroscientists find famous optical illusion surprisingly potent
3. Scientists sequence endangered Tasmanian devils genome
4. Scientists identify a novel mechanism for evolution of highly aggressive cancers
5. Singapore scientists discover how to control fate of stem cells
6. Scientists Zero In on Key Melanoma Links
7. Scientists develop first ever drug to treat Celtic gene in cystic fibrosis sufferers
8. Scientists Turn Memory On, Off in Rats With Flip of Switch
9. Scientists Pinpoint Parts of Brain That Help People Recognize Themselves
10. Several methods for early diagnosis of Alzheimers disease developed by European scientists
11. Scientists image beginning stages of ovarian cancer growth with time-lapse technique
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... ... “When the Stars Lead Home”: a poignant story of loss, determination, and ... Douglas, an avid reader who lives in the Pacific Northwest with her husband, daughter, ... Adventure Camp. She couldn’t be more grateful. , Twelve-year old Tizzy could not believe ...
(Date:5/26/2017)... ... , ... “Just What Happened in the Garden of Eden”: retells the stories of three Bible ... creation of published author, Penelope Colt, mother, trader, horse farmer, artist and a former GM ... was three. At six, they moved to Dayton, Ohio, where Penny graduated high school. ...
(Date:5/24/2017)... ... May 24, 2017 , ... Last month, ... Ellen, hospital employees, and town officials to celebrate the grand opening of the ... by Rendina as part of its ongoing relationship with RWJBarnabas Health, New Jersey’s ...
(Date:5/24/2017)... ... May 24, 2017 , ... Altec Products, Inc., a leader ... – a one-day technology conference in San Diego, CA. , At nVerge 2017, ... to fully utilize and enhance their Sage ERP solutions by providing improved visibility and ...
(Date:5/24/2017)... ... ... Dr. Manju R. Kejriwal, a leading Ohio dentist, is now welcoming new ... Dr. Kejriwal understands the emotional and financial toll traditional orthodontics can take on patients’ ... longer need to feel the esthetic effects of wires and brackets when they can ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... May 5, 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), ... 100,000 square feet to its Welch Allyn campus. ... commitment to bring more than 100 new jobs to ... Allyn has maintained a significant presence for more than ... new positions, a large portion of which will be ...
(Date:5/4/2017)...  A recent study published in the American ... as a means of disinfection anesthesia workstations ... on anesthesia workstations. In the study, UVC disinfection ... equipment surfaces contaminated with three (3) organisms commonly ... further validates the body of literature supporting Tru-D," ...
(Date:5/4/2017)... Mass. and SAN DIEGO ... Obstetricians and Gynecologists (ACOG) 2017 Annual Clinical and Scientific ... single-use, self-contained, illuminating medical devices, today announced the launch ... of its OfficeSPEC and ER-SPEC ... the addition of extra-small and extra-large sizes makes OBP ...
Breaking Medicine Technology: