Navigation Links
Scientists identify novel way to prevent cardiac fibrosis
Date:4/22/2008

vision, migration and motility.

We found that Epac activation exerts a very important impact on the function of fibroblasts, the cells responsible for making and secreting collagen and thus for producing tissue fibrosis, said Insel. Most exciting was our discovery that multiple agents that promote fibrosis decrease the expression and activation of Epac in fibroblasts from several different tissues not only in the heart but also in lung, liver and skin.

The researchers found decreased Epac expression in regions near the site of heart attacks in rats and mice. In addition, they found that by increasing Epac expression, they were able to block the ability of agents to promote fibrosis.

Because increases in cAMP levels can decrease the function of fibroblasts after cell injury, stimulation of the cAMP signaling pathway is a potential way to blunt fibrosis. Increases in Epac expression may provide a novel way to do this, especially in cardiac fibroblasts, Insel added. To test this possibility, the scientists treated fibroblast cells in culture in ways that altered Epac expression, increasing Epac expression using an adenoviral construct.

Using this strategy to overexpress Epac, we produced an anti-fibrotic effect, thereby inhibiting the synthesis of collagen said Insel. Other experiments showed that decreasing Epac expression favored fibrosis; in other words, were pro-fibrotic. Overall, the results show the central role of Epac in determining pro-fibrotic and anti-fibrotic response.


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... Bio probe being developed, screening women for cervical cancer could ... inserted into the vagina, and the woman herself can do ... measures electrical resistance. ,It is so small that ... than taking up the routine Pap smear that is being ...
... developing fatal heart disease say researchers. A new study ... anxieties including the fear of crowded places, heights or ... psychosocial factors such as emotions, anxiety and anger to ... disease. Studies in men suggest anxiety, specifically phobic anxiety, ...
... to a treatment regimen already consisting of chemotherapy and ... among women with high-risk breast cancer with few long ... 1979 and 1986, 318 patients were randomly assigned to ... a 20-year follow-up, researchers found the chemotherapy/radiation combination, compared ...
... or broiled fish, such as tuna, may lower stroke ... 4,775 adults 65 and older. Study participants answered food-frequency ... 12 years. ,Results showed 626 of the participants ... ate broiled or baked fish one- to four-times per ...
... findings of a recent study researchers say weight gain after ... risk for postmenopausal women who // are not taking hormone ... women, ages 50 to 74, by asking them about their ... the women have been periodically asked to provide updates on ...
... days of physical inactivity, the body's efficient use of insulin ... ,Researchers conducted a study in rats and found insulin sensitivity ... stopped running for two days after a period of running ... muscle in response to insulin was found to have decreased ...
Cached Medicine News:Health News:Understanding The Link Between Phobias And Fatal Heart Disease 2
(Date:12/15/2014)...   DaVita HealthCare Partners Inc.  (NYSE: ... and most innovative health care communities, today announced ... Clinical Research  (DCR) and  HealthCare Partners Clinical Research , ... clinical research and data analytics services, specifically in ... renal disease (ESRD), as well as primary care ...
(Date:12/14/2014)... , Dec. 14, 2014  ChartSpan, a consumer ... most downloaded iPhone and iPad medical app in ... - http://photos.prnewswire.com/prnh/20141214/164317 ChartSpan is ... ability to request, manage and send electronic healthcare records. ... entrepreneurs who grew tired of waiting for the healthcare ...
(Date:12/13/2014)... Dec. 12, 2014  Radiologists can transmit their ... to their referring physicians, electronic health records (EHR) ... selected technology.  That was the ... Corporation (ADS) at the recent Radiology Society of ... of radiology reports in this manner also helps ...
Breaking Medicine Technology:DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 2DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 3DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 4ChartSpan Becomes The Most Downloaded Medical App in America 2ChartSpan Becomes The Most Downloaded Medical App in America 3Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 3
... Sept. 9, 2011 Nektar Therapeutics (Nasdaq: ... company,s Phase 2 clinical study of NKTR-102 in patients ... 2011 Breast Cancer Symposium in San Francisco, California.  NKTR-102 ... proprietary polymer conjugate technology, and is being developed in ...
... BRUSSELS, September 9, 2011 The Board of ... that today it agreed to ratify the proposal of the ... legislative package, designed with the help of EFCG and US ... Drug User Fees Act (GDUFA). GDUFA requires the ...
Cached Medicine Technology:Positive Results from Phase 2 Clinical Study of NKTR-102 in Metastatic Breast Cancer Presented in Oral Session at the ASCO 2011 Breast Cancer Symposium 2Positive Results from Phase 2 Clinical Study of NKTR-102 in Metastatic Breast Cancer Presented in Oral Session at the ASCO 2011 Breast Cancer Symposium 3Positive Results from Phase 2 Clinical Study of NKTR-102 in Metastatic Breast Cancer Presented in Oral Session at the ASCO 2011 Breast Cancer Symposium 4Positive Results from Phase 2 Clinical Study of NKTR-102 in Metastatic Breast Cancer Presented in Oral Session at the ASCO 2011 Breast Cancer Symposium 5Positive Results from Phase 2 Clinical Study of NKTR-102 in Metastatic Breast Cancer Presented in Oral Session at the ASCO 2011 Breast Cancer Symposium 6European Fine Chemicals Group Ratifies FDA's Proposed Generic Drug User Fees Act (GDUFA) 2
... and Alliance Catheter Delivery System ... introduction of catheters or devices ... a superior approach. These introducers ... peel-away introducer performance with a ...
This unique hemostatic seal provides a simple option for beating heart CABG anastomoses, allowing you to use your own hand-suturing technique without the release of cerebral emboli associated with th...
... design and ergonomic handle for easy ... Nitinol markers on the proximal and ... visibility. Corrugated ring design provides flexibility ... ring pattern minimizes stent shortening, provides ...
... catheters comprise the world's broadest line ... procedures. Their advanced catheter design and ... response with a soft, atraumatic tip. ... sizes, Supreme and Response catheters provide ...
Medicine Products: