Navigation Links
Scientists identify new target to battle rheumatoid arthritis
Date:5/20/2012

inflammatory macrophages attack joints and they produce inflammatory mediators that basically sustain inflammation in joints," said Dr. Hu.

In experiments, researchers found that knockout mice that lack the Notch pathway in macrophages were unable to produce certain type of macrophages and exhibited a lesser inflammatory phenotype.

"Notch is essential for the development and function of a cell type called the inflammatory macrophages and if this pathway is missing in mice, then you don't get good differentiation of the inflammatory macrophages," said Dr. Hu. In a nutshell, the Notch pathway is essential for the differentiation and function of inflammatory macrophages, and these macrophages are critical for human RA pathogenesis.

In a series of test tube studies, the researchers flushed out the specifics of how Notch influences the molecular cascade that leads to generation of inflammatory macrophage. In another experiment, the investigators used an inhibitor of the Notch pathway called GSI-34 that is under development and showed that this drug could inhibit the function of macrophages.

The researchers say the study provides the first explanation of how Notch contributes to rheumatoid arthritis pathogenesis. It also shows, for the first time, that investigational Notch inhibitors under development for cancer and Alzheimer's could potentially be used to treat RA. Several Notch inhibitors are under development by various companies and a few are currently in Phase III trials.

"Before this study, the Notch pathway has been implicated mainly in cancer, but in this study we define how it is connected to RA," said Dr. Hu.


'/>"/>

Contact: Phyllis Fisher
fisherp@hss.edu
212-606-1724
Hospital for Special Surgery
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. Scientists discover distinct molecular subtype of prostate cancer
2. Scientists study serious immune malfunction
3. Scientists discover marker to identify, attack breast cancer stem cells
4. CNIO scientists successfully test the first gene therapy against aging-associated decline
5. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
6. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
7. Scientists Map Melanomas Genome
8. Scripps Research scientists show how memory B cells stay in class to fight different infections
9. Joslin scientists identify important mechanism that affects the aging process
10. NIH scientists link quickly spreading gene to Asian MRSA epidemic
11. Warwick scientists uncover how checkpoint proteins bind chromosomes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists identify new target to battle rheumatoid arthritis
(Date:5/25/2013)... great companions for senior citizens, but elderly people who always ... likely to crash than those who never drive with a ... licensed drivers aged 70 and older. The nearly 700 participants ... their pet in the car. Among those who always ... high as among those who never drove with their pet. ...
(Date:5/25/2013)... (PRWEB) May 25, 2013 Providing patients with ... Diet Doc team of weight management professionals. But, aside from ... and effectively, Diet Doc’s hCG diets also provide ... abuse during childhood like bullying, more control over their lives ... of dealing with the underlying factors of weight gain derived ...
(Date:5/25/2013)... NY (PRWEB) May 25, 2013 ... problems, ranging from irritable bowel syndrome (IBS) to ... are among the most long-lasting, embarrassing, frustrating and ... natural foods for digestive health have provided ... there are many factors contributing to digestive health ...
(Date:5/25/2013)... 2013 Many orthodontists have thought about ... exactly that cloud is. Most people would naturally ... to provide their cloud service and support would own ... service they're selling, they'd be wrong. Cloud providers ... secure, redundant facility that houses servers and related equipment ...
(Date:5/25/2013)... 25, 2013 The Slim Weight Patch has ... results. This is due to the highly sought after ingredients ... weight patch offers an extra 2 months supply & premium ... and get the body you desire faster than ever. , ... , With Slim weight patch consumers can observe instant ...
Breaking Medicine News(10 mins):Health News:Seniors More Likely to Crash When Driving With Pet: Study 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces hCG Diet Plans for Those Suffering from Abuse-Related Weight Gain 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces hCG Diet Plans for Those Suffering from Abuse-Related Weight Gain 3Health News:Natural Foods For Digestive Health Report and Video Published by BetterDigestion.org 2Health News:Cirrus Ortho Launches Cloud Computing for Orthodontic Industry That is Unlike Any Other 2Health News:Slim Weight Patch Advanced Weight Loss System Offers Extra Two Month Supply and Membership for Maximum Weight Loss 2
... weight training has grown over the past decade. A ... and Policy of The Research Institute at Nationwide Children,s ... weight training has increased as well. The study found ... in U.S. hospital emergency departments between 1990 and 2007, ...
... Parents usually call the shots; doctors unclear in their explanations, ... children with cancer who are enrolled in clinical research trials, ... in research from their parents and doctors, a new report ... cancer patients, ages 7 to 18, and found that ...
... ... girls’ health and education. IDOL GIVES BACK to benefit the UN Foundation Wednesday, April 21, ... Washington, DC ... in Ethiopia as a guest of the United Nations Foundation to learn about ...
... , ... Jackson, MI, based manufacturing and design firm, has brought over 35 years of experience ... and antimicrobial copper carts, storage cabinets, workstations, and tables, as well as cleaning and ... ...
... Don Chapin, one ... AARP article entitled "Love is (Not) All You Need." In the AARP article, the ... to protect their remaining savings to be Medicaid compliant. According to Chapin, the advice ... ...
... from Boston University School of Medicine found that women with ... lower risk of developing gout than men. This study, ... and gout risk in women, also evaluated purported risk factors ... use, and diuretic use to be among leading contributors for ...
Cached Medicine News:Health News:New national study examines weight training-related injuries 2Health News:New national study examines weight training-related injuries 3Health News:Many Kids Not Fully Informed of Their Role in Cancer Studies 2Health News:AMERICAN IDOL's David Cook Travels to Ethiopia with the UN Foundation 2Health News:AMERICAN IDOL's David Cook Travels to Ethiopia with the UN Foundation 3Health News:Midbrook Medical Brings Industrial Experience to Medical Fabrication 2Health News:Midbrook Medical Brings Industrial Experience to Medical Fabrication 3Health News:Prominent National Elder Law Attorney Disputes AARP Article Recommending Divorce to Afford Health Care 2Health News:Prominent National Elder Law Attorney Disputes AARP Article Recommending Divorce to Afford Health Care 3Health News:Obesity, hypertension, alcohol and diuretic use -- gout risk factors for women 2
(Date:5/23/2013)... , May 23, 2013  The need to ... treatment continuum was highlighted prominently at the 108 ... Association (AUA), in San Diego.  According to SonaCare ... focused ultrasound (HIFU) technology, the need for image-guided ... for urologists to consider minimally invasive ablative treatments, ...
(Date:5/23/2013)... , May 23, 2013  Texas, premier physician associations ... doctors the survival tools they need to provide demonstrably ... today,s health care marketplace. "I am confident ... local practices," said Stephen L. Brotherton ... " Texas doctors are determined to ...
(Date:5/23/2013)... TARRYTOWN, N.Y. , May 23, 2013 /PRNewswire/ ... reconstruction following mastectomy is an appropriate option ... mutations seeking to surgically reduce their breast cancer ... involves a gradual expansion process and a second ... of implants in the same surgery as mastectomy ...
Breaking Medicine Technology:Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 2Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 3Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 4Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 5Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 6TMA Launches Physician Services Organization for Patient Care 2TMA Launches Physician Services Organization for Patient Care 3TMA Launches Physician Services Organization for Patient Care 4Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 2Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 3
... WASHINGTON, June 20, 2011 The Consumer Healthcare ... response to Texas Governor Rick Perry signing into ... allowing law-abiding citizens to access common cold and ... that exceed the legal limit: "We ...
... a pilot for as long as he can remember.  His passion ... play with toy planes instead of cars, and grew when he ... to Disney World.  At 8-years old Baniecki scribbled down on a ... placed it into a time capsule.  Ten years later, Baniecki pulled ...
Cached Medicine Technology:Pilot's Dream Comes True Thanks to New Robotic Surgery 2Pilot's Dream Comes True Thanks to New Robotic Surgery 3Pilot's Dream Comes True Thanks to New Robotic Surgery 4
... Total PSA method for Dimension integrated ... is an in vitro diagnostic test ... specific antigen (TPSA) in human serum ... an aid in the detection of ...
... offers a comprehensive line of pregnancy tests ... urine in convenient one-step stick and cassette ... options. Clearview Easy HCG is a 25 ... format. Clearview HCG II provides 25mIU ...
The BioCheck hCG ELISA is intended for the quantitative determination of human chorionic gonadotropin (hCG) concentration in human serum. The assay is for use in the early diagnosis of pregnancy in a...
The BioCheck Ferritin ELISA is intended for the quantitative determination of ferritin in human serum. This assay is to be used in the diagnosis of diseases affecting iron metabolism....
Medicine Products: