Navigation Links
Scientists identify new strategy to fight deadly infection in cystic fibrosis
Date:1/23/2013

COLUMBUS, Ohio New research suggests that lowering excessive levels of a protein in immune system cells could be a strategy to clear an infection that is deadly to patients with cystic fibrosis (CF).

Researchers determined that normalizing levels of the protein, called p62, in cells from mice carrying the most common mutation that causes CF will jump-start a natural cellular process that clears away the offending bacteria.

The scientists had previously determined that in cells from mice and humans carrying the CF mutation, the bacteria that cause this infection interfere with an important survival process in immune system cells; they also attributed this interference to elevated levels of p62.

The survival process, called autophagy, allows a cell to digest parts of itself to produce energy when it is experiencing starvation. In many infections, autophagy also helps digest pathogens and clear them away.

The bacterium, Burkholderia cenocepacia, causes a severe and persistent lung infection in patients with CF and is resistant to nearly all known antibiotics. Various types of chronic lung infection are responsible for about 85 percent of deaths in CF patients.

"Autophagy also controls inflammation, so when you decrease p62 levels in a CF mouse model and that improves autophagy, you are controlling inflammation produced by Burkholderia cenocepacia. And that's what we are trying to do for patients save them from inflammation," said Amal Amer, associate professor of microbial infection and immunity and internal medicine at Ohio State University and senior author of the study.

While relatively rare, B. cenocepacia infection is highly transmissible in patients with cystic fibrosis. By causing either severe sepsis or massive inflammation that damages lung tissue, the infection amounts to a death sentence for CF patients.

To lower p62 levels, the researchers introduced a small interfering RNA molecule, or
'/>"/>

Contact: Amal Amer
amal.amer@osumc.edu
614-247-1566
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Social Scientists call for more effective teaching in Higher Education
2. UT MD Anderson scientists find protein that reins in runaway network
3. Study Finds Older Male Scientists Likelier to Commit Research Fraud
4. NIH scientists identify protective role for antibodies in Ebola vaccine study
5. Johns Hopkins neuroscientists win National Academy of Science Awards
6. Scientists find a new way to boost common cancer drugs
7. Cancer scientists determine mechanism of 1 of the most powerful tumor-suppressor proteins, Chd5
8. New American Chemical Society video series: Conversations with Celebrated Scientists
9. Scientists discover how deadly skin cancer spreads into other parts of the body
10. Scientists ID New Genetic Connection for Gout
11. Scientists Shed Light on Fungus Behind Deadly Pneumonia Strain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Wash.Researchers at Washington State University Spokane have developed ... about to nod off behind the wheel. , ... wheel movementswhich are more variable in drowsy driversand ... currently available video-based driver drowsiness detection systems. , ... when a car is drifting out of its ...
(Date:4/23/2014)... American Society for Radiation Oncology (ASTRO) has issued ... Therapy for Endometrial Cancer: An ASTRO Evidence-Based Guideline," ... in the treatment of endometrial cancer. The guideline,s ... issue of Practical Radiation Oncology (PRO), ... full-length guideline is available as an open-access article ...
(Date:4/23/2014)... important enzyme pathway that helps prevent new cells from ... that has been directly linked to cancer and other ... that near the end of cell division, the enzyme ... in DNA are fully repaired before the parent cell ... process helps safeguard against some of the most devastating ...
(Date:4/23/2014)... 23, 2014Men whose testosterone falls below normal levels are ... overweight and have heart disease and type 2 diabetes. ... men for further testing and possible treatment is described ... , a peer-reviewed publication from Mary Ann Liebert, Inc., ... Journal of Men,s Health website at http://www.liebertpub.com/jmh ...
(Date:4/23/2014)... (April 23, 2014) The American Gastroenterological Association ... 2014 AGA Research Scholars. The AGA Research Scholar ... to develop independent and productive research careers in ... Awards fund an additional year allowing for three ... to supporting junior faculty who are paving the ...
Breaking Medicine News(10 mins):Health News:WSU innovation improves drowsy driver detection 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 3Health News:Study identifies enzymes that help fix cancer-causing DNA defects 2Health News:AGA announces 2014 Class of AGA Research Scholars 2
... Housing NYC,s Homeless & Mentally IllNEW YORK, April 29 ... shed light on it, philanthropic-minded New Yorkers will raise ... the mentally ill and physically disabled. As federal ... health services in the current economy, supporters will raise ...
... the first about his popular cookie-based diet, Dr. Sanford Siegal combines ... history of weight-loss diets through the Ages , ... ... Diet Book (Hyde Park Publishing Ltd., hardcover, 320 pages, ISBN 978-0-9822728-3-1) ...
... Khanna, founder of the Khanna institute of LASIK is Featured ... LASIK, PRELEX and his expanding practice. , ... Westlake, ... of the Khanna Institute of LASIK, was featured in the highly ...
... leader in on-demand workforce development and productivity, announced today that ... staffing, and management, has switched to the LearnCenter platform to ... partners. , ... (PRWEB) April 29, ...
... cleanup from this year,s record floods continue in the Fargo-Moorhead ... providing the city some badly needed good news. Fargo ... cities for ozone pollution, short-term particle pollution and long-term particle ... live in areas that failed all three tests. The rest ...
... strikes, because of severe pain, often accompanied by nausea and ... up to 72 hours. Since they are forced to stop ... subside, migraine causes a significant loss in productivity at work ... especially the 25% of migraineurs who experience more than three ...
Cached Medicine News:Health News:Weston United Celebrates Mental Health Month on May 19th 2Health News:Dr. Siegal's Cookie Diet Book by Sanford Siegal, D.O., M.D., Available May 22nd 2Health News:Dr. Siegal's Cookie Diet Book by Sanford Siegal, D.O., M.D., Available May 22nd 3Health News:Dr. Siegal's Cookie Diet Book by Sanford Siegal, D.O., M.D., Available May 22nd 4Health News:Dr.Khanna Featured in Highly Respected Trade Journal 2Health News:Dr.Khanna Featured in Highly Respected Trade Journal 3Health News:Emergency Consultants Inc. switches to Learn.com to deliver Continuing Medical Education (CME) courses to physicians 2Health News:Emergency Consultants Inc. switches to Learn.com to deliver Continuing Medical Education (CME) courses to physicians 3Health News:Migraine prevention by targeting glutamate receptors? 2Health News:Migraine prevention by targeting glutamate receptors? 3
(Date:1/15/2014)...  Zafgen, Inc., a leading biopharmaceutical company dedicated to ... today announced initial results from its Phase 2a ... aminopeptidase 2 (MetAP2), in patients with Prader-Willi syndrome ... results showed improvements in body weight, hunger-related behaviors, ...
(Date:1/14/2014)... (Nasdaq: LMNX ) today announced that it expects ... Monday, February 3, 2014. A press release announcing the results ... (Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ) Management will ... financial results for the fourth quarter and twelve months ended ...
(Date:1/14/2014)... Dynamic Healthcare Services, Inc. ("DHS"), a portfolio company of GMH ... Medical Equipment, Inc. ("Progressive") of Clarion, PA ... were not disclosed. Progressive is a full ... of sleep, mobility, and respiratory products to customers in the ...
Breaking Medicine Technology:Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3
... (NASDAQ: REGN) today announced that it will report ... April 26, 2012, before the U.S. financial markets open.  The ... that day. Live audio of the conference ... webcast may be accessed from the ,Events and Presentations, page ...
... ST. PAUL, Minn., April 11, 2012 Gamma Pharmaceuticals, ... company focused on alternative delivery systems for everyday ... of a Distribution Agreement with Purchase Order for ... order is for approximately $70,000 retail value.  Gamma ...
Cached Medicine Technology:Gamma Pharmaceuticals, Inc. Announces Distribution Agreement for New York Tri-state Area and Purchase Order for Gamma Energy GEL™ 2Gamma Pharmaceuticals, Inc. Announces Distribution Agreement for New York Tri-state Area and Purchase Order for Gamma Energy GEL™ 3
... Vista 1500 integrated system will ... (integrated multisensor technology) and LOCI ... integrate analysis of electrolytes, general ... drugs, immunosuppressive drugs, plasma proteins, ...
... flexibility to floor-mounted X-ray systems. The ... the C-arm around the exam table ... angle for cardiac and general angiography. ... flat panel detector that delivers outstanding ...
... In-office. Information. In real time. The FemExam pH ... elevated vaginal fluid pH (pH >= 4.7) and ... is easy to use and delivers accurate results ... a swab containing unprocessed vaginal fluid across each ...
The Polygraf ID multi-parametric recorder works with POLYGRAM NET analysis software to create a unique interface that combines web-style navigation, graphical presentation and intuitive design to del...
Medicine Products: