Navigation Links
Scientists identify new protein in the neurological disorder dystonia
Date:5/6/2014

MANHATTAN, Kan. A collaborative discovery involving Kansas State University researchers may lead to the first universal treatment for dystonia, a neurological disorder that affects nearly half a million Americans.

Michal Zolkiewski, associate professor of biochemistry and molecular biophysics at Kansas State University, and Jeffrey Brodsky at the University at Pittsburgh co-led a study that focused on a mutated protein associated with early onset torsion dystonia, or EOTD, the most severe type of dystonia that typically affects adolescents before the age of 20. Dystonia causes involuntary and sustained muscle contractions that can lead to paralysis and abnormal postures.

"It's a painful and debilitating disease for which there is no cure or treatment that would be effective for all patients," Zolkiewski said. "There are some treatments that are being tested, but nothing is really available to those patients that would cure the symptoms completely."

In addition to Zolkiewski and Brodsky, researchers involved in the study included Hui-Chuan Wu, Kansas State University doctoral student in biochemistry and molecular biophysics, Taiwan, and colleagues at the University of Texas Southwestern Medical Center and the University of Adelaide in Australia.

The Journal of Biological Chemistry recently published the team's study, "The BiP molecular chaperone plays multiple roles during the biogenesis of TorsinA, a AAA+ ATPase associated with the neurological disease Early-Onset Torsion Dystonia." The study was funded by the Dystonia Medical Research Foundation.

Researchers built the study on a decade-old discovery that patients with early onset torsion dystonia typically have a mutated gene that encodes the protein TorsionA.

"TorsinA is a protein that all people have in their bodies," Zolkiewski said. "It appears to perform an important role in the nervous system, but currently nobody knows what that role is. Ther
'/>"/>

Contact: Michal Zolkiewski
michalz@k-state.edu
785-532-3083
Kansas State University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists awarded grant to develop diagnostics for cancer, rheumatoid arthritis, colitis
2. Norwegian neuroscientists elected to National Academy of Sciences
3. NIH scientists establish monkey model of hantavirus disease
4. Stanford scientists create circuit board modeled on the human brain
5. A civil war inside our cells: Scientists show how our bodies fight off jumping genes
6. Scientists find way to target cells resistant to chemo
7. Scientists identify cancer specific cell for potential treatment of gastric cancer
8. Scientists pinpoint protein that could improve small cell lung cancer therapies
9. AMP publishes curriculum recommendations for medical laboratory scientists
10. Scientists alter fat metabolism in animals to prevent most common type of heart disease
11. Scientists discover a new way to enhance nerve growth following injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... August 21, 2014 The City of ... for entertainment and programming for its inaugural “Re:Imagine Garden ... October 12, 2014, from 11 a.m. to 4 p.m., ... all cars and the downtown will be filled with ... by Community Arts Resources (CARS), for all to enjoy. ...
(Date:8/21/2014)... News) -- Not only is eating better and exercising healthy ... health-care dollars a year, a new study finds. The ... sciences at Wake Forest Baptist Medical Center in Winston-Salem, N.C., ... diabetes patients. Participants ranged in age from ... intensive "lifestyle change program" focused on diet and exercise, or ...
(Date:8/21/2014)... THURSDAY, Aug. 21, 2014 (HealthDay News) -- Among seniors, ... suggests. The study involved more than 2,500 people, aged ... the study and again two, six and eight years later. ... in the person,s risk of death during the study period, ... and effect, researchers led by Sharon Christ of Purdue University ...
(Date:8/21/2014)... The W. Montague Cobb/ NMA ... national voice in the elimination of health disparities, ... the 112th National Medical Association’s (NMA) Annual Convention ... John Ruffin, Ph.D, former Director of the National ... life-long career and innovations have had a significant ...
(Date:8/21/2014)... Rockville, MD (PRWEB) August 21, 2014 ... Pediatrics reported a 63% increase in disability associated with ... along with a more than 15% increase in disability ... of early intervention for rising numbers of children who ... Speech-Language-Hearing Association (ASHA). , On a broader ...
Breaking Medicine News(10 mins):Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 2Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 3Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 4Health News:Getting Healthier a Big Money-Saver for People With Diabetes 2Health News:Failing Vision Tied to Shorter Lifespans for Seniors 2Health News:W. Montague Cobb/NMA Health Institute Honors Three Outstanding Leaders in Health Disparities 2Health News:New Pediatrics Study Reveals Dramatic Increase in Speech Problems in Children Over Past Decade 2Health News:New Pediatrics Study Reveals Dramatic Increase in Speech Problems in Children Over Past Decade 3
... KING OF PRUSSIA, Pa., June 30 TMG Health ... the recipient of the,Ernst & Young Entrepreneur Of The ... & Young, the awards program was designed to,recognize outstanding ... building and leading dynamic, growing businesses. Jack Tighe,was selected ...
... Declaration Survey, SEOUL, Korea, June 30 ... the workplace and keeping,it top of mind with ... keeping employees safe, according to a DuPont-sponsored survey ... The survey results are the basis for the ...
... Management,Technologies, Inc., (OTC Bulletin Board: WNDM), has announced ... its wound care product,CellerateRx(R), with EWA Government Systems, ... and validates that CellerateRx is,destined to play a ... fragments (CRX) are a fraction of the size ...
... in Spanish . , The " La Mente ... Faculty of Arts at the University of the Basque Country analyses ... the brain acquires and manages languages and to discover in what ... , In order to understand how we become fluent in ...
... named,Richard L. Wonsettler to the newly created position of ... Wonsettler, who has nearly 20 years of financial,management experience ... that Cohera Medical is preparing to enter the clinical ... "We are entering an important phase in the ...
... 30 /PRNewswire-FirstCall/ - SXC Health Solutions Corp.,("SXC" or ... a leading provider of,technology and pharmacy benefits management ... for its informedRx(R) pharmacy benefit management,("PBM") services with ... begin providing its services for more than 6,000 ...
Cached Medicine News:Health News:TMG Health President and CEO Jack Tighe Named Ernst & Young Entrepreneur Of The Year(R) 2008 in Philadelphia Region 2Health News:TMG Health President and CEO Jack Tighe Named Ernst & Young Entrepreneur Of The Year(R) 2008 in Philadelphia Region 3Health News:Companies Report Success in Driving Safety Culture at Workplaces 2Health News:Companies Report Success in Driving Safety Culture at Workplaces 3Health News:Companies Report Success in Driving Safety Culture at Workplaces 4Health News:Wound Management Technologies, Inc. Announces Sales Agreement with EWA Government Systems, Inc. 2Health News:Wound Management Technologies, Inc. Announces Sales Agreement with EWA Government Systems, Inc. 3Health News:Laka: 'Language exists in the brain' 2Health News:Laka: 'Language exists in the brain' 3Health News:Laka: 'Language exists in the brain' 4Health News:Cohera Medical Names Richard L. Wonsettler as Company's First CFO 2Health News:The University of Toledo selects SXC Health Solutions (informedRx) to provide pharmacy benefit management services 2Health News:The University of Toledo selects SXC Health Solutions (informedRx) to provide pharmacy benefit management services 3
(Date:8/21/2014)... , Aug. 21, 2014  Seventy-one percent of Americans ... OxyContin is a serious public health and safety issue in ... from a survey released today by Repass & Partners, a ... "Americans understand the severity of the prescription medication ... progress with this very serious health situation facing our country," ...
(Date:8/21/2014)... 21, 2014 InfinityQS International, Inc., the ... Intelligence , today announces Infusion Chicago, its 9 ... be held Oct. 9-10, 2014, at the Chicago ... showcase the necessity for implementing a quality system ... Intelligence to gain insight into production processes. Complimentary ...
(Date:8/21/2014)... Professional Compounding Centers of America (PCCA) ... the three best scientific presentations at the sixth ... The Formulating Better Medicines for Children  conference, ... Athens, Greece , includes dozens of poster-style ... which three winners will be selected by a ...
Breaking Medicine Technology:Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3InfinityQS to Host Manufacturing Intelligence Conference in Chicago 2Professional Compounding Centers of America will award top poster-session winners at European Paediatric Formulation Initiative in Athens 2
... April 21 Tomato products may protect against ... recent multi-center, randomized, controlled trial on the effects ... in overweight and obese men and women, presented ... Giordano, Ph.D. on April 19, 2009 at the ...
... Leads to Weight Loss, Lower Blood Sugar and Improved A1CHORSHAM, ... a leading weight loss program that delivers to your door, ... loss program designed specifically for the approximately 24 million Americans ... are at risk for diabetes. In a clinical study ...
Cached Medicine Technology:Processed Tomato Products May Protect Against Inflammation, According to a Study Presented at the Experimental Biology Meeting 2Processed Tomato Products May Protect Against Inflammation, According to a Study Presented at the Experimental Biology Meeting 3New Weight Loss Hope for People with Diabetes 2New Weight Loss Hope for People with Diabetes 3New Weight Loss Hope for People with Diabetes 4New Weight Loss Hope for People with Diabetes 5New Weight Loss Hope for People with Diabetes 6
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: