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Scientists identify new leads for treating parasitic worm disease
Date:3/16/2008

ith schistosomiasis.

The TGR project submitted to NCGC by Dr. Williams group was the first one officially accepted for screening by the NIH Roadmap Molecular Libraries Initiative. The results of that collaboration underscore the value of a new paradigm established by the NCGC, which is administered by the National Human Genome Research Institute (NHGRI). The high-tech center offers academic researchers, such as the ISU team, the opportunity to tap into a robotic system for quickly screening large numbers of chemical compounds for biological activity.

Chemical genomic advances are being used to develop a new approach to a parasite that has afflicted countless generations of humankind, said NHGRI Director Francis S. Collins, M.D., Ph.D. This study showcases the beauty of high-throughput chemical screening for biomedical applications.

NCGC Director Christopher P. Austin, M.D., who is a co-author of the Nature Medicine paper, said Our center has brought pharmaceutical-scale chemical screening, informatics and medicinal chemistry to bear on neglected diseases that affect millions globally, but are not worked on by the pharmaceutical industry since they cannot generate the needed financial returns. This study demonstrates the wonderful things that can happen when the NCGCs scientific capabilities and infrastructure are combined with the biological expertise of individual academic investigators.


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Contact: Raymond MacDougall
macdougallr@mail.nih.gov
301-443-3523
NIH/National Human Genome Research Institute
Source:Eurekalert

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