Navigation Links
Scientists identify molecule that can increase blood flow in vascular disease
Date:3/10/2011

CHAPEL HILL, N.C. Circulating through the bloodstream of every human being is a rare and powerful type of cell, one that can actually create new blood vessels to bypass blockages that cause heart attacks and peripheral artery disease. Though everyone has these cells called endothelial progenitor cells they are often dysfunctional in people prone to vascular disease.

Now researchers at the University of North Carolina at Chapel Hill have discovered that a molecule called Wnt1 can improve the function of endothelial progenitor cells, increasing the blood flow to organs that previously had been cut off from the circulation. The finding could enhance clinical trials already testing these powerful cells in patients hospitalized with cardiac arrest.

"The premise of these trials is that these cells will supply the ischemic organ with new blood vessels and allow the damaged organ to function better," said senior study author Arjun Deb, MD, assistant professor of medicine in the UNC School of Medicine. "But because you are isolating these cells from the patients themselves, you know that the cells are dysfunctional -- so the approach is almost flawed from the very beginning. We want to see how we can improve the function of these cells so they can do their job better."

The study, published online Feb. 14, 2011, in the FASEB (Federation of American Societies for Experimental Biology) Journal, is the first to show that the Wnt1 protein, one of a family of 19 such molecules, can stimulate blood vessel formation.

A number of studies in the past few years have suggested that genes that play an important role during early development and get "turned off" during adulthood may also get "turned on" or expressed again in response to injury, such as heart attack.

Deb, who studies the Wnt family of developmental genes, looked to see if any of its members follow this same pattern. He found that one gene in particular, Wnt1,
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists identify molecule that can increase blood flow in vascular disease
(Date:8/20/2014)... No matter how “lonely” a person may ... set of friends to be always there for them. However, ... concept of making new friends during adulthood : not ... taking care of one’s family to a near-slavish devotion to ... new person just is not the same as it was ...
(Date:8/20/2014)... 2014 Blaine Labs®, the creators ... RevitaDERM® Psoriasis Treatment to ease the redness, ... This all-in-one product was created to treat, moisturize, ... is powered by coal tar and formulated to ... effective ingredient. , RevitaDERM® Psoriasis Treatment is ...
(Date:8/20/2014)... First Choice Emergency Room , ... the United States, named Richard Daniels, DO the Medical ... , “We are pleased to announce that Dr. ... second facility in Pflugerville,” said Dr. James M. Muzzarelli, ... , Dr. Daniels received his undergraduate degree from Brigham ...
(Date:8/20/2014)... August 20, 2014 What to Do ... Locked Out of the Market, **FDAnews Webinar**, Sept. 11, ... http://www.fdanews.com/DoNowforUDI , Hospitals and other buyers of devices ... ineffective product tracking systems. , Complying with the FDA’s ... demands to implement UDI as soon as possible. ...
(Date:8/19/2014)... As moms and dads prepare their children to go ... normal routine of dropping their little ones off at daycare ... encourages them to use the opportunity to implement a ... Yarker explains, “Kids have small tummies, short attention spans, and ... food handouts, use snack time as another daily opportunity to ...
Breaking Medicine News(10 mins):Health News:‘How to Make Friends as an Adult by Just Being Yourself: Becoming a “People Person” In Three Steps or Less’ Gives Tips for Making Friends During Adulthood - Vinamy 2Health News:RevitaDERM® Psoriasis Treatment Now Available At Over 7,600 CVS/pharmacies 2Health News:First Choice Emergency Room Announces Dr. Richard Daniels as Medical Director of the Pflugerville – FM 685 Facility 2Health News:FDAnews Announces — What to Do Now for UDI: Don’t Lose Your Customers by Getting Locked Out of the Market Webinar, Sept. 9, 2014 2Health News:FDAnews Announces — What to Do Now for UDI: Don’t Lose Your Customers by Getting Locked Out of the Market Webinar, Sept. 9, 2014 3Health News:FDAnews Announces — What to Do Now for UDI: Don’t Lose Your Customers by Getting Locked Out of the Market Webinar, Sept. 9, 2014 4Health News:Child Nutritionist Kristen Yarker Wants Parents to Rethink Kids’ Snacks This Fall 2Health News:Child Nutritionist Kristen Yarker Wants Parents to Rethink Kids’ Snacks This Fall 3
... UP WITH CROSSFIT TRAINER ANDY PETRANEK TO TACKLE THE ... an Olympic medalist to the growing list of female ... Andrea Duran is part of a burgeoning movement of ... the same grueling, high-intensity workouts used to train the ...
... to Address Rising Health Costs and Lost Economic OpportunityWASHINGTON, ... to the nation last night, Ken Thorpe, Ph.D., Executive ... on the Obama Administration to address the tremendous cost ... spending priorities of the nation in the year ahead. ...
... Telehealth Solutions, Adds Accomplished Financial Executive to its Senior Management Team ... ... TeleCare, Inc. (ATI) announced that Michael A. Brodeur has joined the ... the development and application of video-based telehealth solutions to advance patient ...
... Feb. 25 Practicing Clinicians Exchange (PCE) has ... (NFA) to provide continuing education programs to nurse ... United States in 2009.The partnership is beneficial to ... nonprofit group dedicated to improving the quality of ...
... (March 1, 2009) Even in the best economic ... cancer screening receive the life-saving test. Those without health ... colorectal cancer screenings are even less likely to be ... Gastroenterological Association (AGA) is working to raise awareness of ...
... offering to over 30,000 MembersNew Agreement with Diversified ... the new Fitness Industry Sales ChannelFORT LAUDERDALE, Fla., ... ), and Diversified Health & Fitness, Inc. today ... promote eDiets, award-winning, fresh-prepared diet meal delivery service ...
Cached Medicine News:Health News:CrossFit: A Workout Fit for an Olympian 2Health News:Partnership Calls on President to Attack Budget-Busting Crisis of Chronic Disease 2Health News:American TeleCare, Inc. (ATI) Appoints Michael A. Brodeur as Chief Financial Officer 2Health News:American TeleCare, Inc. (ATI) Appoints Michael A. Brodeur as Chief Financial Officer 3Health News:Practicing Clinicians Exchange Forms Partnership With National Fibromyalgia Association 2Health News:Practicing Clinicians Exchange Forms Partnership With National Fibromyalgia Association 3Health News:Economy could reduce colorectal cancer screening rate 2Health News:eDiets.com(R) and Diversified Health & Fitness Announce New Strategic Marketing Partnership 2Health News:eDiets.com(R) and Diversified Health & Fitness Announce New Strategic Marketing Partnership 3Health News:eDiets.com(R) and Diversified Health & Fitness Announce New Strategic Marketing Partnership 4
(Date:8/19/2014)... 2014 /PRNewswire-iReach/ -- ChemImage founder and CTO, Patrick ... describing an innovative diagnostic procedure for the detection of ... on Disease (SPEC) conference in Krakow, Poland ... "Development of in vitro Diagnostics for Detection of Colorectal ... the conference poster session on Tuesday, August 19, 2014 ...
(Date:8/19/2014)...  As power morcellator lawsuits continue to mount ... notes that women in need of fibroid removal ... options that do not involve the use of ... report published by The Wall Street Journal on ... mini-laparotomy and vaginal hysterectomy. Non-surgical options for shrinking ...
(Date:8/19/2014)... Aug. 19, 2014 Research and Markets ... Drugs - Global Strategic Business Report" report to their ... for Human Growth Hormone Drugs in US$ Million by the ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ...
Breaking Medicine Technology:ChemImage Scientists Present Latest Developments for in vitro Detection of Colorectal Cancer Using Raman Molecular Imaging (RMI) at International Conference Focused on Biomedical Applications of Raman Spectroscopy 2As Morcellator Lawsuits Mount, Bernstein Liebhard LLP Notes Report Detailing Alternatives to Uterine Morcellation 2As Morcellator Lawsuits Mount, Bernstein Liebhard LLP Notes Report Detailing Alternatives to Uterine Morcellation 3Global Human Growth Hormone Drugs - Strategic Business Report 2014 2
... iMRI is a neurosurgical OR that ... diagnostic tools, including iMRI, necessary to ... iMRI, neurosurgical treatments are performed in ... designed for MR compatibility and safety, ...
... Neuropack M1 is an advanced ... system. It is a sophisticated 2 ... MEB-2200. 2 electrical stimulations, 2 sound ... goggles stimulation. You can customize each ...
Every so often a new product comes along that isn't a small step but a giant leap ahead of everything that has preceeded it. Such is the impact of the Fidelity IAB....
... Dimension cardiovascular ultrasound system is the world's ... fully integrated real-time 4D and multi-dimensional imaging ... member of the Vivid 7 family, provides ... diagnosing heart conditions such as heart failure ...
Medicine Products: