Navigation Links
Scientists identify major source of cells' defense against oxidative stress
Date:4/6/2012

Both radiation and many forms of chemotherapy try to kill tumors by causing oxidative stress in cancer cells. New research from USC on a protein that protects cancer and other cells from these stresses could one day help doctors to break down cancer cells' defenses, making them more susceptible to treatment.

In the March 23 issue of the Journal of Biological Chemistry, scientists led by USC Professor Kelvin J. A. Davies demonstrated that a protein known as Nrf2 governs a cell's ability to cope with oxidative stress by increasing the expression of key genes for removing damaged proteins.

Typically, oxidative stress is to be avoided. People eat foods high in antioxidants (such as fruits and vegetables) to try to block oxidation in their cells, in hopes of lowering their risk of illnesses such as cancer, heart disease, stroke and Alzheimer disease which are all linked to oxidative stress.

But in the case of cancer cells, if the Nrf2 response could some day be selectively turned off, treatments like chemotherapy and radiation could be more effective, Davies said.

"One of the problems you have is that cancer cells start becoming resistant to those treatments: they adapt," said Davies, who holds joint appointments in the USC Davis School of Gerontology the USC Dornsife College of Letters, Arts and Sciences. "The next time they may be more resistant because they've seen it before."

Nrf2 is a transcription factor protein, meaning that it binds to specific sequences of DNA, turning on the process of copying the blueprints encoded in those DNA sequences into functional enzymes. In particular, the new work from the Davies lab shows that production of proteasome and a proteasome regulator (Pa28) is controlled by Nrf2 during oxidative stress. Proteosome, in turn, is a large protein enzyme that breaks down oxidized proteins that would otherwise accumulate and cause cells to die.

When oxidative stress increases (si
'/>"/>

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists uncover multiple faces of deadly breast cancer
2. Scientists solving the mystery of human consciousness
3. A*STAR scientists discover special class of natural fats stimulates immune cells to fight diseases
4. Hutchinson Center and TGen scientists discover potential break through in pancreatic cancer
5. Scientists study link between amyloid beta peptide levels and Alzheimers disease
6. Scientists measure how energy is spent in martial arts
7. Scientists link 2 cancer-promoting pathways in esophageal cancer
8. Hutchinson Center scientists break through pancreas cancer treatment barrier
9. Sanford-Burnham scientists unravel cancer drugs secret to resistance
10. Scientists develop a software tool for estimating heart disease risk
11. UCLA scientists uncover mechanism for melanoma drug resistance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... Skmen.com, a well-known clothing manufacturer, has announced its promotion ... middle of September, all the company’s new and old ... 30 percent off. , As a matter of ... made and come with quality guarantees. They can certainly ... popular for its fashionable, high quality clothes for men ...
(Date:8/30/2014)... Information supplied by insurance companies has been helping ... consumers in 2014. A group of ratess for term ... open system for adults at http://quotespros.com/life-insurance.html . ... year can help the average person to quote a ... from medical histories. The finder tool works under a ...
(Date:8/30/2014)... 30, 2014 Hands On ... which offers the complete spa experience combining elegant ... and the most important ingredient of all, states ... licensed pro's! People will enjoy the get-away feel, ... The website reads, "Step into the spacious, luxurious ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 Daily Gossip reveals ... the Make Him Desire You program, who shows a unique ... The author of this method says that the program goes ... The Make Him Desire You review indicates that the program ... insider advice and his great techniques to make a man ...
(Date:8/30/2014)... August 30, 2014 Daily Gossip reveals in ... Infection is a method created by Sarah Summer, who can ... The author of this new program actually had to deal ... sufferer to be able to access it, in an all-natural ... determination in finding an effective cure for yeast infection. The ...
Breaking Medicine News(10 mins):Health News:Huge Deals On 2014 Long Casual Dresses Unveiled By Skmen.com 2Health News:Term Life Insurance Rates Now Found Nationally by New Insurer Finder Tool 2Health News:Hands On Mobile Massage and Spa of Long Island Now Offers a Spa-on-wheels 2Health News:Make Him Desire You Review Reveals Powerful Formula to Make a Man Emotionally Addicted 2Health News:Natural Cure for Yeast Infection Review Exposes New Natural Treatment 2
... ... Country’s Pest Management Needs, , ... (PRWEB) April 29, 2010 -- Most people are aware of the destruction caused by the ... the country is still dealing with widespread damage to its infrastructure and health and safety ...
... prebiotics (found in some foods) may help alleviate the ... a new research study appearing in the May 2010 ... ( http://www.jleukbio.org ), differing intestinal bacteria in celiac ... that manipulating the intestinal microbiota with dietary strategies such ...
... ... Cafés has been steadily increasing over the past two years since expansion in the State ... the Florida Council on Compulsive Gambling’s (FCCG) 24-Hour Problem Gambling HelpLine document the damage to ... ...
... ... claims process, reaffirm need for qualified SSDI representation , ... Belleville, IL (Vocus) April 29, 2010 -- Combating ... Security Administration (SSA), the federal agency has launched a number of initiatives to expedite ...
... Protecting ... 100’s of children around the world. Despite it being French Law to protect any swimming pool ... ... to all swimming pool owners to follow swimming pool legislation and not to leave pools a ...
... ... their newborns, is one of the most effective ways to save the lives of preterm ... NAP, Inc.’s Sleepy Wrap baby carrier provides several benefits for preterm babies requiring Kangaroo Mother ... Boulder, CO (PRWEB) ...
Cached Medicine News:Health News:Clark Pest Control Executive Asked to Aid Haitian Government with Post-Earthquake Pest Issue 2Health News:Clark Pest Control Executive Asked to Aid Haitian Government with Post-Earthquake Pest Issue 3Health News:Gut bacteria offer new insights -- and hope -- for people with celiac disease 2Health News:Internet Sweepstakes Cafe's…Already Causing Impact on Gambling Problems in Florida 2Health News:Allsup Outlines Quick-Processing Methods for Social Security Disability Claims 2Health News:Allsup Outlines Quick-Processing Methods for Social Security Disability Claims 3Health News:Allsup Outlines Quick-Processing Methods for Social Security Disability Claims 4Health News:Allsup Outlines Quick-Processing Methods for Social Security Disability Claims 5Health News:Allsup Outlines Quick-Processing Methods for Social Security Disability Claims 6Health News:Du Toit & Associates Prepare to Prevent Silent Deaths by the Pool this Summer 2Health News:NAP, Inc.'s Sleepy Wrap Baby Carrier is Helpful for Preterm Babies Requiring Kangaroo Mother Care 2Health News:NAP, Inc.'s Sleepy Wrap Baby Carrier is Helpful for Preterm Babies Requiring Kangaroo Mother Care 3
(Date:8/29/2014)... Research and Markets has announced the addition ... Pharmaceutical Equipment Market in China, 2014-2018" report to ... Forecast of Pharmaceutical Equipment Market in China ... pharmaceutical equipment industry in the aspects of current ... performance of domestic major enterprises, as well as offers ...
(Date:8/29/2014)... 2014 According to the ... Services (Equipment, Reagent, Primer, Probe, Custom Oligos), End-User ... Gene Synthesis, NGS, DNA, RNAi) - Global Forecast ... Synthesis Market is expected to reach $1,712.1 Million ... at a CAGR of 9.8% from 2014 to ...
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire-iReach/ -- ChemImage will ... the Australian and New Zealand Forensic Science Society,s ... Sciences in Adelaide, Australia . ... concerning the advancements that hyperspectral imaging can bring ... Jeffrey Beckstead , Director of Product Development at ...
Breaking Medicine Technology:Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3
... Grafts have met the challenges of the ... years. Recognized for exceptional performance and quality, ... surgeons worldwide. These grafts require no preclotting, ... and assure utmost thrombectomy safety. The Gore ...
... INTERING Vascular Graft, the newest vascular graft ... a leader in vascular surgical products for ... by reducing kinking and compression problems ... new graft provides all of the benefits ...
... newest vascular graft offering from W. L. ... surgical products for more than two decades, ... compression problems that can lead to ... of the benefits of a ring graft ...
... newest vascular graft offering from W. L. ... surgical products for more than two decades, ... compression problems that can lead to ... of the benefits of a ring graft ...
Medicine Products: