Navigation Links
Scientists identify key roadblock to gene expression
Date:5/8/2008

A team of scientists has provided, for the first time, a detailed map of how the building blocks of chromosomes, the cellular structures that contain genes, are organized in the fruit fly Drosophila melanogaster. The work identifies a critical stop sign for transcription, the first step in gene expression, and has implications for understanding how the AIDS virus regulates its genes. The findings will be published in the 15 May 2008 issue of the journal Nature.

The scientists found that nucleosomes--chromosomal building blocks made up of proteins around which DNA is coiled--occur at precise locations along genes that are actively undergoing transcription. They also showed that RNA polymerase--the enzyme that reads genes as the first step in making proteins--is stopped at the first nucleosome, where it remains idle until it is directed to continue moving forward. "This discovery is important because nucleosomes are barriers to transcription and we now are seeing the impact of nucleosome organization on RNA polymerase," said lead investigator B. Franklin Pugh, professor and Willaman Chair in Molecular Biology at Penn State University.

Using state-of-the-art ChIP-sequencing, a genome-mapping tool provided by collaborator Stephen S. Schuster, Penn State professor of biochemistry and molecular biology, and computational predictions developed by collaborators Ilya Ioshikhes, an assistant professor at Ohio State University, and Istvan Albert, a research assistant professor of bioinformatics at Penn State, the scientists precisely mapped the locations of hundreds of thousands of nucleosomes. The scientists then compared these maps to the team's earlier maps of the baker's yeast Saccharomyces cerevisiae, revealing that evolution has organized nucleosomes differently in simple life forms compared to more complex organisms like the fruit fly.

In yeast, a nucleosome sits on top of the transcription start site, so RNA polymerase must contend
'/>"/>

Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists identify interacting proteins key to melanoma development, treatment
2. The American Psychiatric Associations Awards for Young Scientists Encourage Research Expertise in China
3. Scientists identify gatekeepers of breast cancer transition to invasive disease
4. Scientists at Yale provide explanation for how cancer spreads
5. Brookhaven scientists explore brains reaction to potent hallucinogen
6. Scientists Discover How Stomach Tumors Form
7. U.S. Scientists Receive Japan Prize on April 23, 2008
8. Scientists discover a mechanism that can send cells on the road to cancer
9. Scientists identify novel way to prevent cardiac fibrosis
10. Scientists Explore Human Gene Pool With Help From Microsoft Research
11. Scientists obtain anticancer medicines from the elecampe, a wild plant growing in the Mediterranean
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... "The second toes cross over the big toes on my ... an inventor from East Hartford, Conn. This gave him idea ... He then created a prototype of the Comfort Sock, which ... toes from overlapping. This avoids discomfort and pain, which allows ... use, it's ideal for people with foot problems, athletes and ...
(Date:7/12/2014)... York, New York (PRWEB) July 12, 2014 ... continue to move forward in U.S. courts, Bernstein Liebhard ... ties elevated metal ion levels to the failure of ... July 2nd issue of The Journal of Bone & ... had received unilateral Articular Surface Replacement prostheses at least ...
(Date:7/12/2014)... NY (PRWEB) July 12, 2014 ... 2020 - New and Late-Stage Four-Factor PCCs and ... analysis of the critical care market in the ... Canada. The report provides an estimation of market ... 2020. It covers critical care indications that are ...
(Date:7/12/2014)... Arab Emirates (PRWEB) July 12, 2014 ... Los Angeles basketball legend is heading to the UAE. ... and six-time champion will be in the UAE from ... Fitness Weekend in support of diabetes awareness. The event ... award-winning entertainment marketing and event management company based in ...
(Date:7/12/2014)... Restore My Vision Today is a ... a couple boasting very impressive credentials on the field ... Today as a way to help consumers do without ... their respective patients’ treatments . , In ... trove of pertinent information relevant to eye care like:, ...
Breaking Medicine News(10 mins):Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 2Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 3Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6Health News:Los Angeles Basketball Legend Headed to Dubai 2Health News:Los Angeles Basketball Legend Headed to Dubai 3Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 3
... Omega-3 polyunsaturated fatty acids it has been revealed that ... benefits. // ,They influence mood, personality and behavior ... by University of Pittsburgh School of Medicine researchers at ... Society in Denver. ,The study comprised 106 ...
... who died on Saturday suspected to be of bird flu ... high alert.// ,The 32-year-old man is believed ... a busy city in China's Guangdong province, bordering Hong Kong. ... and died within nine days of hospitalisation. ,Many ...
... Justice Cyriac Joseph has expressed the need for quality ... must not leave any stone unturned to weed out ... Justice, this is a matter of grave concern to ... education. The educationists, professionals, governments and all the stakeholders ...
... University Medical Center researchers have discovered that distinct regions ... faced with ambiguous choices versus// choices involving only risk. ... risky choices, and how such risk-taking can become an ... were published in the journal Neuron. ,The ...
... and sound health info Kerala and Goa have lifted the ... revealed by Minister for Medical Education and Animal Husbandry V.S. ... that this indicates that the situation is under control. ... make policies Chief Minister H.D. Kumaraswamy said the Government has ...
... decided to test the effects of radiation released from of ... human skin in order to determine if these transmissions are ... is scheduled to begin sometime next week will expose a ... phone radiation for about 60 minutes or the duration of ...
Cached Medicine News:Health News:Distinct Brain Sections Are Activated While Making Risky Decisions 2
(Date:7/10/2014)... 10, 2014  BC Technical, the largest nationwide, non-OEM ... , Inc., a leading provider of Siemens Nuclear Medicine ... agreement naming BC Technical as the authorized provider of ... MiE and BC Technical announced today that the two ... Technical as the service and systems provider for MiE,s ...
(Date:7/10/2014)... , July 10, 2014   Ventana Medical Systems, ... announced it has entered into an agreement with Merck ... as EMD Serono in the United States ... collaborate with Merck KGaA,s biopharmaceutical division on the development ... undisclosed target using Ventana,s proprietary diagnostic assays. In alignment ...
(Date:7/10/2014)... 2014   LabStyle Innovations Corp . (OTCQB:DRIO), developer ... the appointment of Professor Richard B. Stone ... of Directors. Prof. Stone brings over ... LabStyle as an entrepreneur, venture capitalist public, company ... expert. He currently serves on the board of ...
Breaking Medicine Technology:BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4
... With obesity in America reaching alarming levels -- across our adult and youth ... who used BodyMedia,s wearable body-monitoring technology either in conjunction with a group weight loss ... three times more weight than individuals who attempted ... ...
... Ill., March 11 The U.S. Food ... supplemental new drug application (sNDA) of a new six-month ... Depot (leuprolide acetate for depot suspension) for ...  Palliative treatment helps to relieve symptoms associated with advanced ...
Cached Medicine Technology:The Results are in: Users of BodyMedia's Wearable Body-Monitoring Technology Lose 3 Times More Weight 2The Results are in: Users of BodyMedia's Wearable Body-Monitoring Technology Lose 3 Times More Weight 3The Results are in: Users of BodyMedia's Wearable Body-Monitoring Technology Lose 3 Times More Weight 4The Results are in: Users of BodyMedia's Wearable Body-Monitoring Technology Lose 3 Times More Weight 5The Results are in: Users of BodyMedia's Wearable Body-Monitoring Technology Lose 3 Times More Weight 6Abbott Seeks FDA Approval of a New Six-Month 45-mg Formulation of Lupron(R) Depot for the Palliative Treatment of Advanced Prostate Cancer 2Abbott Seeks FDA Approval of a New Six-Month 45-mg Formulation of Lupron(R) Depot for the Palliative Treatment of Advanced Prostate Cancer 3Abbott Seeks FDA Approval of a New Six-Month 45-mg Formulation of Lupron(R) Depot for the Palliative Treatment of Advanced Prostate Cancer 4Abbott Seeks FDA Approval of a New Six-Month 45-mg Formulation of Lupron(R) Depot for the Palliative Treatment of Advanced Prostate Cancer 5Abbott Seeks FDA Approval of a New Six-Month 45-mg Formulation of Lupron(R) Depot for the Palliative Treatment of Advanced Prostate Cancer 6Abbott Seeks FDA Approval of a New Six-Month 45-mg Formulation of Lupron(R) Depot for the Palliative Treatment of Advanced Prostate Cancer 7
... slot into the side ... monitor, so patient information ... patient's side. Data is ... and storage at the ...
... Telemetry System is a telemetry system ... which require monitoring and performance. With ... able to monitor patients from virtually ... and wireless bedsides. Now, monitoring your ...
TeleRehab Advantage is a monitoring system that automates the generation of outcomes data. Patient information and session information is automatically transferred from the monitoring program to Outc...
... Clearly, the ISI Lexan Universal ... surgical table for lower and ... head and neck, and lower ... traction package gives you the ...
Medicine Products: