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Scientists identify key component in lethal lung cancer complication
Date:6/13/2011

lung cancer patients who have two copies of this mutation one from each parent are more likely to develop hypercalcemia even before their blood work shows elevated levels of calcium.

"The significance of this is if you have two copies of the mutation, it would be ideal for a clinician to know that you have this mutation and start pre-emptive fluid therapy or other preventive treatment. Even in the normal calcium range, this mutation is going to set a person up for hypercalcemia much earlier than other patients," Lorch said.

Calcium-sensing receptors are present in other areas of the body, which complicates their status as a potential drug target specifically for hypercalcemia in lung cancer, Lorch noted. She is continuing to study this receptor and others in a family of proteins known as G-protein-coupled receptors, which are important to tumor initiation, promotion and development.


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Contact: Gwendolen Lorch
gwendolen.lorch@cvm.osu.edu
614-292-9698
Ohio State University
Source:Eurekalert

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