Navigation Links
Scientists identify key component in lethal lung cancer complication
Date:6/13/2011

then tested the cell lines to see how much calcium it would take for the receptors on those cells to produce the maximum amount of the PTHrP hormone. All three lines produced the highest hormone levels when the calcium concentration reached the equivalent of 12 milligrams per deciliter of calcium in blood in humans the level at which hypercalcemia is diagnosed. Normal values range from 8.5 to 10.2 milligrams per deciliter.

"This told us that when people are hypercalcemic, they are producing the maximum level of PTHrP," Lorch said.

An experiment in mice confirmed the calcium-sensing receptor's role. Mice were injected with either regular tumor cells or cells from which the calcium-sensing receptor had been stripped away. Mice that received cells without the receptor developed hypercalcemia in 49 days, compared to 29 days for mice that received typical tumor cells, which do have the receptor.

"That's a very big difference in time in mice," Lorch said. "This suggests that the calcium-sensing receptor was necessary for the rapid development of hypercalcemia."

The receptors on those cells also behaved as expected in additional cell line experiments exploring their behavior after the PTHrP hormone was released. All three lines led to the release of what is known as intercellular calcium, but at different levels and rates. One line in particular stood out. This line, called HARA, had previously produced the most PTHrP when stimulated with calcium, and then released much more excess calcium than the other two cell lines.

These findings in the tissue studies led the scientists to sequence the calcium-sensing receptors in the three cell lines to look for genetic variants. The HARA line contained a mutation known as a single nucleotide polymorphism, or SNP (pronounced snip), that influenced how much of the PTHrP protein the receptors produced and how much calcium it took to stimulate that action.

What this means is that
'/>"/>

Contact: Gwendolen Lorch
gwendolen.lorch@cvm.osu.edu
614-292-9698
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Swine flu spread was much wider than first thought, scientists say
2. Einstein scientists find crucial molecule involved in spread of breast cancer
3. Scientists create humanized mouse model for hepatitis C
4. Scientists unlock potential of frog skin to treat cancer
5. The New York Stem Cell Foundation awards fellowships to 7 innovative stem cell scientists
6. UCSB scientists discover new direction in Alzheimers research
7. Indiana University neuroscientists map a new target to wipe pain away
8. NIH scientists reactivate immune cells exhausted by chronic HIV
9. Scientists identify overactive genes in aggressive breast cancers
10. Tie Between Biomarkers, Disease Often Overstated, Scientists Say
11. California scientists discover how vitamins and minerals may prevent age-related diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 26, 2014 It is said that nothing ... Today, UWDress.com, the famous wedding dress supplier, shows its ... site-wide cocktail gown promotion. , UWDress.com’s navy cocktail gowns ... they come in high fashion styles. Simple dresses in bright ... the occasion; they are specially designed for those who want ...
(Date:12/26/2014)... 26, 2014 Plugin and template developers from ... 5 Plugin for Final Cut Pro X. , “TransPack Volume ... tool to pull off an industry professional look” Said Christina ... hands on TransPack Volume 5, a new level of professionalism ... set of over 50 Final Cut Pro X transitions featuring ...
(Date:12/26/2014)... 2014 DW-InductionHeating.com (DaWei Induction Heating Co.) ... and developing, producing and marketing of a series of ... announces their new series of induction brazing equipments ... company, induction brazing refers to the joining ... material and heat. The manager says that there are ...
(Date:12/25/2014)... (PRWEB) December 26, 2014 ... BambooFlooringChina.com combines beauty, strength and durability. Today, the ... promotion, which is valid until Jan. 30, 2015. ... grain of traditional hardwood. BambooFlooringChina.com is a well-known ... help consumers worldwide to find a reliable bamboo ...
(Date:12/25/2014)... three months the trends for evening dresses shift ... one of the hottest styles in the next few months.” ... releases 26 A-line sweetheart evening dresses, and announces the availability ... are trying our best to help a lady to show ... affordable prices, we provide discounted delivery costs to our customers ...
Breaking Medicine News(10 mins):Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2Health News:Today a new plugin was announced from Pixel Film Studios, TransPack Volume 5 for Final Cut Pro X 2Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2
... The Food and Drug Administration has cleared a new diagnostic ... thousands of AIDS patients stricken with cryptococcosis, a fungal meningitis. ... professor of microbiology of the University of Nevada School of ... of Oklahoma. The new, rapid blood test known as ...
... -- Obesity is costing states up to $15 billion each ... already accounts for 10 percent or more of the state,s ... University and the U.S. Agency for Healthcare Research and Quality. ... large part of the bill, with the state,s share of ...
... (HealthDay News) -- Chicks and ducklings from a mail-order hatchery ... United States, the U.S. Centers for Disease Control and Prevention ... 65 people in 20 states and Salmonella Johannesburg ... 54 of the people infected with the Altona strain found ...
... , New York, NY, August 24, 2011 Nearly three-quarters (72%) ... their jobs over the last two years said that they ... because of cost, according to a new Commonwealth Fund ... or medical debt, compared to about half (49%) who lost ...
... WEDNESDAY, Aug. 24 (HealthDay News) -- Exclusive breast-feeding of ... them against developing the itchy skin disorder known as ... breast-feeding, an infant receives only breast milk, with no ... Organization. Exclusive breast-feeding up to 6 months of age ...
... as well as others in Canada and the United ... major motion pictures that depict smoking -- leading to ... of California, San Francisco (UCSF) researcher has found. ... , those subsidies, along with government inaction on stricter ...
Cached Medicine News:Health News:FDA clears new IMMY and University of Nevada, Reno life-saving blood test 2Health News:Obesity Costing States Billion in Yearly Medical Expenses 2Health News:Three-quarters of those who have lost jobs and health insurance are skipping needed health care 2Health News:Three-quarters of those who have lost jobs and health insurance are skipping needed health care 3Health News:Three-quarters of those who have lost jobs and health insurance are skipping needed health care 4Health News:Breast-Feeding Won't Prevent Kids' Eczema, Researchers Say 2Health News:Taxpayer film subsidies promote youth smoking 2
(Date:12/24/2014)... , Dec. 23, 2014 In response to ... Association of Sierra Leone , Direct Relief ... for the treatment of local health workers who ... a new dedicated Ebola care center was constructed for foreign ... facility is not available for local Sierra Leonean health workers. ...
(Date:12/22/2014)... NxStage Medical, Inc. (NASDAQ: NXTM ... announced today that the U.S. Food and Drug ... perform hemodialysis overnight while the patient is at ... System One is the first and only hemodialysis ... Home nocturnal hemodialysis is an ...
(Date:12/22/2014)... 2014 Research and Markets ( ... "Investment Analysis of the US Medical Device ... http://photos.prnewswire.com/prnh/20130307/600769 ... device sector identifies the key trends and rationale ... and mergers and acquisitions. The study ...
Breaking Medicine Technology:First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3Investment Analysis of the US Medical Device Sector 2
... BETHESDA, Md., July 05, 2007 /PRNewswire-FirstCall/ -- Micromet,Inc. ... of,novel, proprietary antibody-based products for cancer, inflammatory,and autoimmune ... Chief Executive Officer of Micromet, Inc., will,present at ... in New York on Thursday, July 12, 2007 ...
... WIRE)--Jul 2, 2007 - Tercica, Inc.,(NASDAQ:TRCA) today announced ... at the C.E. Unterberg, Towbin,Emerging Growth Opportunities Conference ... Wednesday, July 11, 2007 at 4:00 p.m. Eastern,time ... and slide presentation will be available,via the Internet ...
Cached Medicine Technology:Micromet, Inc. to Present at the 3rd Annual C.E. Unterberg, Towbin,Emerging Growth Conference 2
... The new E300 Corneal ... diverse range of clinical procedures ... Refractive Surgery and Contact Lens ... compact cone design, the E300 ...
Egg-Shaped Bioceramic orbital implants insert easily into orbital socket and will not cling to surrounding tissue. Improved interconnectivity between pores enhances vascularization. Implants may be e...
... The S7 with Discrete Technology ... plus unmatched scaffolding. Proprietary Secure Technology ... proximal pillows that partially encapsulate the ... Discrete Technology is designed to minimize ...
Increased stent scaffolding at the proximal end gives optimal lumen support and 6F guide catheter compatibility and improved tracking offer excellent deliverability. Customized balloon lengths for ea...
Medicine Products: