Navigation Links
Scientists identify interacting proteins key to melanoma development, treatment
Date:5/6/2008

Researchers have discovered how a mole develops into melanoma by showing the interaction of two key proteins involved in 60-70 percent of tumors. The Penn State scientists also demonstrate that therapeutic targeting of these proteins is necessary for drugs to effectively treat this deadly form of cancer.

"We have shown that when two proteins (V600E)B-Raf and Akt3 communicate with one another in a mole, they cooperate leading to the development of melanoma," said Gavin Robertson, lead author and associate professor of pharmacology, pathology and dermatology, and director of the Foreman Foundation Melanoma Therapeutics Program at the Penn State College of Medicine Cancer Institute. "We have also shown that effective therapies for melanoma need to target both these proteins, which essentially eliminates the tumors.

Melanoma is the most deadly form of skin cancer because it metastasizes or moves around the body so quickly. In general, people with advanced-stage disease only have months to live. Currently, melanoma kills one person every hour in the U.S., and is predicted to affect one in 50 people by 2010. In recent years, researchers have zeroed in on two key genes B-Raf and Akt3 that cause this deadly cancer, and which could be important targets in the treatment of melanoma.

B-Raf is the most mutated gene in melanoma. The mutant protein, (V600E)B-Raf, produced by this gene is important in helping mole cells survive and grow but it is unable to form melanomas on its own. Nearly 90 percent of all moles have the mutant protein but it is not fully clear why only some of them turn into melanomas.

Robertson and his colleagues have found that a second protein produced by Akt3 regulates the activity of the mutated B-Raf, which aids the development of melanoma.

"What we have found is a second event that is necessary for melanomas to develop," added Robertson, whose findings are reported in the May 1 issue of the
'/>"/>

Contact: Amitabh Avasthi
axa47@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. The American Psychiatric Associations Awards for Young Scientists Encourage Research Expertise in China
2. Scientists identify gatekeepers of breast cancer transition to invasive disease
3. Scientists at Yale provide explanation for how cancer spreads
4. Brookhaven scientists explore brains reaction to potent hallucinogen
5. Scientists Discover How Stomach Tumors Form
6. U.S. Scientists Receive Japan Prize on April 23, 2008
7. Scientists discover a mechanism that can send cells on the road to cancer
8. Scientists identify novel way to prevent cardiac fibrosis
9. Scientists Explore Human Gene Pool With Help From Microsoft Research
10. Scientists obtain anticancer medicines from the elecampe, a wild plant growing in the Mediterranean
11. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... CT (PRWEB) July 11, 2014 ... the nation’s only non-profit dedicated exclusively to cell ... that Joshua Corday has joined the organization as ... fundraising professional with deep experience securing gifts and ... served as Annual Giving Director for NewYork Presbyterian ...
(Date:7/11/2014)... Global enterprises today are shifting towards the ... activities. Managed services offer these global enterprises a strategic ... resulted into rising operational costs to companies. The aim ... be the global market driver for expanding the managed ... services market is estimated to grow from $142.75 billion ...
(Date:7/11/2014)... 11, 2014 Presently, disposable medical suppliers ... equipment and supplies segment. During the past two decades, ... growth (on an average 12.5% per year), primarily owing ... Currently, the US is the largest market for disposable ... of 40%. The second position is held by Europe ...
(Date:7/11/2014)... PROVIDENCE, R.I. -- Researchers from The Miriam ... under age 65 have significantly higher rates of ... with mobility impairments were less likely to attempt ... quit-smoking treatments may not be sufficient for this ... online in advance of print in the ...
(Date:7/11/2014)... of its kind has found that organic foods ... their conventional counterparts, including more antioxidants and fewer, ... at an unprecedented 343 peer-reviewed publications comparing the ... plant-based foods, including fruits, vegetables, and grains. The ... differences between organic and non-organic foods. , ...
Breaking Medicine News(10 mins):Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 2Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 2Health News:Global Disposable Medical Supplies Market to See Robust Growth Through Next Decade, According to New TriMark Report Available at MarketPublishers.com 3Health News:Miriam Hospital study examines smoking prevalence 2Health News:Major study documents nutritional and food safety benefits of organic farming 2Health News:Major study documents nutritional and food safety benefits of organic farming 3
... and the elderly have slower response times when they have ... research suggests that much of that slower response is a ... healthy older people can be trained to respond faster in ... cognitive skills in this area aren,t so different from younger ...
... celiac disease -- an autoimmune disorder associated with a ... than the general population to report symptoms of depression ... gluten-free diet, according to researchers at Penn State, Syracuse ... often suffer from abdominal pain, constipation, decreased appetite, diarrhea, ...
... Teens are more likely to be obese if they had ... toddlers, according to a new study. The findings echo ... ties with their parents were more likely to be obese ... the latest study, researchers examined U.S. National Institute of Child ...
... -- Quitting smoking is one of the most common ... with six of 10 smokers requiring multiple attempts before ... Association. However, preparing a quit-smoking plan can greatly ... the single most important step smokers can take to ...
... The quality of the emotional relationship between a mother ... that child to be obese during adolescence, a new ... characteristics between mothers and their children during their toddler ... terms of the child,s emotional security and the mother,s ...
... team of neuroscientists, led by researchers at Mayo Clinic ... brain disorder that may be much more common than once ... Nature Genetics , the researchers say they identified 14 ... of hereditary diffuse leukoencephalopathy with spheroids (HDLS). This ...
Cached Medicine News:Health News:Elderly can be as fast as young in some brain tasks, study shows 2Health News:Elderly can be as fast as young in some brain tasks, study shows 3Health News:Elderly can be as fast as young in some brain tasks, study shows 4Health News:Women with celiac disease suffer from depression, disordered eating 2Health News:Women with celiac disease suffer from depression, disordered eating 3Health News:Mother-Toddler Bond May Influence Teen Obesity 2Health News:How to Make Your Quit-Smoking Resolution Stick 2Health News:Study links quality of mother-toddler relationship to teen obesity 2Health News:Study links quality of mother-toddler relationship to teen obesity 3Health News:Study links quality of mother-toddler relationship to teen obesity 4Health News:'Rare' brain disorder may be more common than thought, say Mayo Clinic scientists 2Health News:'Rare' brain disorder may be more common than thought, say Mayo Clinic scientists 3
(Date:7/10/2014)... BURLINGTON, Mass. , July 10, 2014 /PRNewswire/ ... three-quarters of surveyed infectious disease (ID) specialists are ... Medicines Company,s Orbactiv (oritavancin) for use as OPAT, ... to prescribe these agents to their hospital inpatients. ... percent) of OPAT patients are initiated on OPAT ...
(Date:1/15/2014)... Sono-Tek Corporation (OTC BB: SOTK) today announced sales of  ... to sales of $2,202,000 for the prior year period, an ... also shown growth over the preceding quarter,s sales, continuing a ... year. Markets that experienced sales increases over the prior year ...
(Date:1/15/2014)... Mich. , Jan. 15, 2014 As health officials ... flu virus, select Meijer pharmacies in Michigan ... throat to eligible patients, enabling Meijer pharmacists to administer tests ... protocol set by a physician participating in the study. ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3
Classic, stylish, and preppy, this collection features men's, women's and unisex styles....
The latest VALENTINO eyewear collection is a refined expression of sophisticated luxury,balancing ultimate feminine, chic styles against understated, minimalist mens models....
Stylish, elegant and feminine, these attractive frames provide refined and beautiful styles for women ages 40 and older....
The Nine West Eyewear collection is positioned to present today's styles with a sharp, edgy contemporary attitude tied into a clean design element....
Medicine Products: