Navigation Links
Scientists identify genes that may signal long life in naked mole-rats

Scientists at the University of Liverpool have identified high levels of a number of genes in the naked mole-rat that may suggest why they live longer than other rodents and demonstrate resistance to age-related diseases.

The Liverpool team has recently generated the first whole-genome sequencing data of the naked mole-rat - a rodent that lives for more than 30 years and is resistant to cancer - to understand its longevity and resistance to disease. Scientists, in collaboration with Harvard University, have now compared the levels of its genes with genes in wild mice to investigate what makes naked mole-rats different to other rodents.

They found that genes associated with mitochondria, that provide energy to cells, and genes that affect respiration and the decisions cells make, are expressed at unusually high levels in the naked mole-rat compared to the same genes in wild mice. In animals and humans these genes are thought to play a role in influencing and adapting to cell damage, which is thought to be one of the significant causes of ageing.

Naked mole-rats, however, also have increased levels of oxidative stress, which is an imbalance in reactive molecules containing oxygen. This can lead to mutations in the cells and the growth of cancerous tumours. To date, cancer has not been detected in the naked mole-rat, but these new findings suggest that the rodent has mechanisms of regulating gene responses to limit the potential negative impact of oxidative stress on cells. The research will help scientists focus on particular areas of the genome to further understanding into how the body ages.

Dr Joao Pedro Magalhaes, from the University's Institute of Integrative Biology, said: "The naked mole-rat is native to the deserts of East Africa and has unique physical traits that allow it to survive in harsh environments for many years. It has a lack of pain sensation in its skin and has a low metabolic rate that allows it to live underground with limited oxygen supply.

"It has been of interest to scientists for some time and we hope that by studying its genome it will help us understand the mechanisms of ageing and how the body protects itself from disease.

"These findings add further evidence to research that suggests genes responsible for mitochondria and oxireduction are associated with the ageing processes. It also provides some clues as to how naked mole-rats protect themselves against high levels of oxidative stress. The high levels of genes connected to energy production and cell decision-making systems may help in creating an intracellular environment that prevents cancer and other age-related diseases.

"This work provides candidate genes for specifying resistance to ageing and cancer that we can build on in future studies. The next stage of the research will be to observe what happens to the cells if gene levels change from high to low and vice-versa."

The research is published in the journal, PLoS ONE.


Contact: Samantha Martin
University of Liverpool

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
(Date:10/13/2017)... ... October 13, 2017 , ... While it’s often important ... problem. Fortunately, an inventor from Austin, Texas, has identified a solution. , She developed ... darkness or restricted lighting. As such, it eliminates the need to turn on a ...
(Date:10/13/2017)... ... , ... PurhealthRX , a leading Health and Nutrition Company, is announcing ... full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the ... incorporated into liquid products, while reducing costs to end users. , The team of ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which ... evacuation of the facility as part of a disaster drill on October 3rd. , ... and Shelton City Emergency Manager, as well as the Connecticut Long Term Care ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... MENLO PARK, Calif. , Oct. 11, 2017 /PRNewswire/ ... a national scientific team that developed an innovative way ... and quantity of the delivery of new drugs. ... the 2017 Fall Clinical Dermatology Conference will show how ... Massachusetts General Hospital, Harvard Medical School used a suite ...
(Date:10/10/2017)...   West Pharmaceutical Services, Inc. (NYSE: WST), ... administration, today shared the results of a study highlighting ... intradermal administration of polio vaccines. The study results were ... 2017 by Dr. Ondrej Mach , Clinical Trials ... (WHO), and recently published in the journal Vaccine. ...
(Date:10/4/2017)... 2017 OBP Medical , a ... devices, today announced regulatory approval from ... Agência Nacional de Vigilância Sanitária (ANVISA)) to market ... retractor with integrated LED light source and smoke ... exposure of a tissue pocket or cavity during ...
Breaking Medicine Technology: