Navigation Links
Scientists identify genes linked to lupus in women
Date:1/20/2008

WINSTON-SALEM, N.C. An international consortium of scientists has identified multiple genes that are linked to systemic lupus erythematosus, a devastating autoimmune disease that affects between 1 million and 2 million Americans. Reporting in Nature Genetics, the scientists also confirmed earlier findings linking lupus to several other genes highlighting the role that genetics plays in the disease.

These findings underscore that numerous genes, which are often immune-function related, contribute to the risk of developing lupus, said Carl D. Langefeld, Ph.D., senior author from Wake Forest University School of Medicine and co-director of the International Consortium for Systemic Lupus Erythematosus Genetics (www.SLEGEN.org).

These results suggest biologic pathways that help us understand the condition better and suggest additional genetic and non-genetic triggers, said Langefeld. In addition, they help delineate the genetic distinctions between rheumatoid arthritis, lupus and other autoimmune diseases, which could lead to earlier, more accurate diagnoses.

Systemic lupus can involve the joints, kidneys, heart, lungs, brain and blood. The disease occurs in about 31 out of every 100,000 people and affects women nine times more frequently than men. Scientists believe that lupus is caused by genetic variants that interact with each other and the environment.

The current study was made possible because of advances in technology that allow researchers to take a more systematic approach to looking at the entire genome. It was supported by the Alliance for Lupus Research and the National Institutes of Health.

The researchers studied the DNA of 720 women of European descent with lupus and 2,337 women without lupus. They scanned the entire genome for more than 317,000 single nucleotide polymorphisms (SNPs), which are locations on chromosomes where a single unit of DNA, or genetic material, may vary from one person to the next. The goal was to identify SNPs linked to lupus. They confirmed these results in another independent set of 1,846 women with lupus and 1,825 women without lupus.

The scientists found evidence of an association with multiple SNPs in three genes: ITGAM, KIAA1542 and PXK, and also at SNP rs10798269, which is not within any known gene. ITGAM is important for both the adherence of immune cells and for cleaning up pathogens. KIAA1542 is important for translating the DNA code into proteins. PXK encodes a molecule that transmits signals and controls complex processes in cells. These scientists also found association in genes previously associated with lupus and other autoimmune diseases.

The scientists are now focusing their attention on specific pathways and genes identified in this study, trying to dissect the precise molecular mechanisms by which these genes contribute to the risk for lupus. Genetic factors likely predict specific complications or patterns of complications. If so, it might be possible to intervene earlier in the process to delay or prevent their onset.

This initial, important discovery will prove invaluable to all those affected by lupus, said Barbara Boyts, president of the Alliance for Lupus Research, which supported the study and continues to support SLEGENs efforts to uncover genetic information about lupus. We are hopeful that this information will lead to new and better treatment possibilities and, eventually, a cure for lupus.

Lupus is a decimating illness, said John Harley, M.D., Ph.D., lead author and SLEGEN director, from the Oklahoma Medical Research Foundation. As researchers, our goal is to reduce the burden of suffering caused by this disease. These findings have opened many new doors, and were excited to investigate whats inside each of them.


'/>"/>

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Scripps research scientists find new genetic mutation that halts the development of lupus
2. Jefferson scientists uncover role of cancer stem cell marker: controlling gene expression
3. Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
4. 2 Hebrew University scientists awarded Wolf Prizes
5. UCLA scientists restore walking after spinal cord injury
6. Scientists Report Refinements to Brain Surgery
7. Jefferson scientists find protein potential drug target for treatment-resistant prostate cancer
8. Scientists Marvel at Santas Stamina
9. Scientists identify brain abnormalities underlying key element of borderline personality disorder
10. Scientists seek to assess the microbial risks in the water we drink
11. Scientists find how bacteria in cows milk may cause Crohns disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... California (PRWEB) , ... June 27, 2016 , ... "FCPX ... fully customizable inside of Final Cut Pro X," said Christina Austin - CEO of ... unique style. Final Cut Pro X users can now reveal the media ...
(Date:6/26/2016)... ... 2016 , ... Quality metrics are proliferating in cancer care, and are derived ... eye of the beholder, according to experts who offered insights and commentary in the ... Care. For the full issue, click here . , For the American Society ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... have been diagnosed with endometriosis. These women need a treatment plan to not ... comprehensive approach that can help for preservation of fertility and ultimately achieving a ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
Breaking Medicine Technology: