Navigation Links
Scientists identify genes linked to lupus in women
Date:1/20/2008

WINSTON-SALEM, N.C. An international consortium of scientists has identified multiple genes that are linked to systemic lupus erythematosus, a devastating autoimmune disease that affects between 1 million and 2 million Americans. Reporting in Nature Genetics, the scientists also confirmed earlier findings linking lupus to several other genes highlighting the role that genetics plays in the disease.

These findings underscore that numerous genes, which are often immune-function related, contribute to the risk of developing lupus, said Carl D. Langefeld, Ph.D., senior author from Wake Forest University School of Medicine and co-director of the International Consortium for Systemic Lupus Erythematosus Genetics (www.SLEGEN.org).

These results suggest biologic pathways that help us understand the condition better and suggest additional genetic and non-genetic triggers, said Langefeld. In addition, they help delineate the genetic distinctions between rheumatoid arthritis, lupus and other autoimmune diseases, which could lead to earlier, more accurate diagnoses.

Systemic lupus can involve the joints, kidneys, heart, lungs, brain and blood. The disease occurs in about 31 out of every 100,000 people and affects women nine times more frequently than men. Scientists believe that lupus is caused by genetic variants that interact with each other and the environment.

The current study was made possible because of advances in technology that allow researchers to take a more systematic approach to looking at the entire genome. It was supported by the Alliance for Lupus Research and the National Institutes of Health.

The researchers studied the DNA of 720 women of European descent with lupus and 2,337 women without lupus. They scanned the entire genome for more than 317,000 single nucleotide polymorphisms (SNPs), which are locations on chromosomes where a single unit of DNA, or genetic materi
'/>"/>

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Scripps research scientists find new genetic mutation that halts the development of lupus
2. Jefferson scientists uncover role of cancer stem cell marker: controlling gene expression
3. Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
4. 2 Hebrew University scientists awarded Wolf Prizes
5. UCLA scientists restore walking after spinal cord injury
6. Scientists Report Refinements to Brain Surgery
7. Jefferson scientists find protein potential drug target for treatment-resistant prostate cancer
8. Scientists Marvel at Santas Stamina
9. Scientists identify brain abnormalities underlying key element of borderline personality disorder
10. Scientists seek to assess the microbial risks in the water we drink
11. Scientists find how bacteria in cows milk may cause Crohns disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/5/2008)...ert Pathologists Discuss the Latest Developments i...RTHFIELD, Ill., Sept. 5 /PRNewswire-USNewswire/ --...point. Molecular testing and the promise,of person...reated. Digital,slides and other imaging technolog...lege of American Pathologists is taking a leadersh...
(Date:9/5/2008)...hers explain how theoretical ,anti-cloak, could br...pt. 5 (HealthDay News) -- Just in case someone dev...cientists say they know how to uncloak the objects... Optics Express , certain materials underneath an ...o be seen again. , Researchers at Shanghai Jiao...
(Date:9/5/2008)...HINGTON, Sept. 5 /PRNewswire-USNewswire/ -- Speake...y in support of the aims of the "Stand,Up to Cance... "There is not a person in our country who has no...r kills 565,000 Americans annually, and each,year ...ricans must work,together to make eradicating the ...
(Date:9/5/2008)...HINGTON, Sept. 5 /PRNewswire-USNewswire/ -- U.S. c...r relief to Cuban victims of Hurricane,Gustav, whi...s., (http://www.PanAmericanRelief.org ), "Donatio...perately need,after this natural disaster," says M... Initiative at the Pan American Development Founda...
Breaking Medicine News(10 mins):Health News:Leaders in Pathology Meet in San Diego: Sept. 25 - 28, 2008 2Health News:Cuban Disaster Relief Donations Sought in the Wake of Hurricane Gustav 2
...industrialised nations summit, which begins on Sat...obal health issues high on its list// of priority....h officer, addressing the press stated that the G8...hat would establish the basic guidelines for comba...
...ds Agency (FSA) has said that one in five take-out...ews for over 1.3 million Britons// who thrive on t...oncern since many fast-food restaurants were found...properly before packing the food. Also infestation...
...k, all of two years, found his eyelids stuck toget...his eye, instead of using it to treat a head// inj...ye Infirmary where he was administered treatment. ...some improvement, though a major portion of the ey...
... about the inherent risks involved in the consumpt...e human milk is capable of causing food poisoning ...ces that the human milk carries remnants of drugs ...when consumed. Even unhygienic storage of milk, an...
Other Medicine News:
(Date:9/4/2008)... Ala., Sept. 4 /- Southern Research I...tes of Health (NIH) has selected,the organization ...ries,Probe Production Center Network (MLPCN). The ...rt of the Molecular Libraries Program which is,des...knowledge of the human,genome and validate future ...
(Date:9/4/2008)...imizing Patient Identification for Targeted Therap...zed Treatment HUNTINGTON BEACH, Calif., and AMS...ia, a world leader in molecular cancer diagnostics...new diagnostic test that,allows physicians to quan...,the estrogen receptor (ER), progesterone receptor...
(Date:9/3/2008)...College of Rheumatology Research and Education Fou...icant Advances in Detecting, T...RNewswire/ -- For the first time during its,unprec...rthritis, the,American College of Rheumatology Res...formation acquired from research funded by the Wit...
(Date:9/3/2008)... showed that Multaq(R) (dronedarone) decreased the...illation or atrial flutter already ad...EWATER, N.J., Sept. 3 /- Th...the ATHENA study were presented today at,the clini...f Cardiology,congress 2008, in Munich, Germany. Pr...
Breaking Medicine Technology:Southern Research Institute Wins $14.7 Million NIH Award to Participate in Molecular Libraries Probe Production Center Network 2Southern Research Institute Wins $14.7 Million NIH Award to Participate in Molecular Libraries Probe Production Center Network 3Southern Research Institute Wins $14.7 Million NIH Award to Participate in Molecular Libraries Probe Production Center Network 4Agendia Launches TargetPrint(R) for Breast Cancer Patients 2New Research Shows Promise for Finding A Cure for Rheumatoid Arthritis 2New Research Shows Promise for Finding A Cure for Rheumatoid Arthritis 3Further Analysis From ATHENA Study Showed That Multaq(R) (dronedarone) Reduced the Risk of Stroke in Patients With Atrial Fibrillation 2Further Analysis From ATHENA Study Showed That Multaq(R) (dronedarone) Reduced the Risk of Stroke in Patients With Atrial Fibrillation 3Further Analysis From ATHENA Study Showed That Multaq(R) (dronedarone) Reduced the Risk of Stroke in Patients With Atrial Fibrillation 4Further Analysis From ATHENA Study Showed That Multaq(R) (dronedarone) Reduced the Risk of Stroke in Patients With Atrial Fibrillation 5NCPA Offers New Immunization CE Program 25168 1NCPA Offers New Immunization CE Program 25168 2Study sees need for standardized evaluation of antibody response to HIV 1 25163 1Study sees need for standardized evaluation of antibody response to HIV 1 25163 2Medical doctors who do research could be a dying breed 4377 1Medical doctors who do research could be a dying breed 4377 2Study helps pinpoint genetic variations in European Americans 4374 1Study helps pinpoint genetic variations in European Americans 4374 2Study helps pinpoint genetic variations in European Americans 4374 3
Used as a percutaneous entry needle to introduce wire guides. The coaxial design reduces potential A.V. malformations. Supplied sterile in peel-open packages. Intended for one-time use.
Used for stone manipulation and removal in the urinary tract. Enhanced wire strength permits the basket to expand the ureter more readily than standard flat-wire designs. The Unidex handle facilitate
...d for stone manipulation and removal in the urinar... to retain its shape following extreme torsion. Th...ture by allowing the basket to open at the base of...ign reduces the likelihood of mucosal damage and p...
Used to establish and maintain nephrostomy drainage following pyeloplasty. Supplied sterile in peel-open packages. Intended for one-time use. CAUTION: Periodic evaluation is advised; stent must not r
Medicine Products: