Navigation Links
Scientists identify gene that is consistently altered in obese individuals
Date:3/21/2013

AUGUSTA, Ga. Food and environment can chemically alter your gene function and scientists have identified a gene that is consistently altered in obesity.

The gene LY86 was among a group of 100 genes identified as likely contributors to obesity through genome-wide association studies comparing the DNA of thousands of obese and lean individuals, said Dr. Shaoyong Su, genetic epidemiologist at the Medical College of Georgia at Georgia Regents University.

Su looked at progressively larger groups of obese versus lean individuals and found LY86 consistently and highly chemically altered, or methylated, in the obese individuals. "The association is solid; the methylation of this gene is important in obesity," Su said.

It's known that obesity is highly inheritable; that if parents are obese, children are at higher risk. However environment, including high-fat foods and chemical exposure, can put you at risk as well, said Su. Methylation is one way the body adjusts to its environment.

He received the 2013 Scott Grundy Fellowship Award for Excellence in Metabolism Research for his studies and is presenting the work this week during the Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism Scientific Session of the American Heart Association in New Orleans.

Previously LY86 had been known as an inflammation gene and Su's studies show, in fact, it may be contributing to more than just obesity. He found high methylation of LY86 also was associated with increased inflammation a risk factor for a variety of maladies such as heart disease and cancer as well as insulin resistance, a cause of diabetes. This association also held up among a group of about 703 subjects that, like the general public, included obese, lean and average-weight individuals.

Now he wants to go back to the animal model to see whether methylation changes gene expression up or down in fat mice as well as fat, pregnant mice and their offspring. He believes that a lot of methylation starts in the womb and there are unfortunate real-life circumstances that support that theory.

For example, in the Dutch famine of 1944 near the end of World War II, babies born to starving mothers experienced DNA methylation that made them better able to survive such depravation, but in the more plentiful environment in which they grew up, put them at increased risk for cardiovascular disease as well as diabetes, obesity and other health problems.

He's already moving forward with more human studies as well, looking at a new group of lean and obese individuals, analyzing their DNA expression to see if increased methylation of LY86 means the gene is expressed more or less. Generally, higher methylation is thought to translate to lower gene expression.

He also wants to pin down whether methylation results from things like a high-fat diet, unfortunate genetics or both. These types of details may help explain why some individuals grow obese with a bad diet and little physical activity while others don't, Su said. It also may mean that positive environmental change, such as a better diet or more physical activity, can reverse at least some of the methylation. People may not get thin, for example, but they may reduce their risk for obesity-related disease, Su said.

LY86's clear importance in obesity emerged by first merging the gene list from the genome wide association studies with a genome wide methylation database on a small cohort of seven obese and seven lean individuals. The finding of increased methylation held up in subsequent groups of 46 obese/46 leans, 230 obese/413 leans as well as the general population panel of 703 at the GRU Institute of Public and Preventive Health. The research was supported by the National Institutes of Health.


'/>"/>

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University
Source:Eurekalert  

Related medicine news :

1. Most men with erectile dysfunction remain untreated, say US scientists
2. Scientists investigate potential markers for a response to sunitinib in patients with metastatic RCC
3. Scientists ID Antibody That Might Boost Cancer Therapy
4. Scientists Report Clues to Flu Shots Effectiveness
5. Scientists discuss relationship between abortion and violence against women
6. A*STAR scientists discover switch critical to wound healing
7. Scientists uncover source of ovarian stem-like cells prone to give rise to ovarian cancer
8. Defective virus surprisingly plays major role in spread of disease, UCLA life scientists report
9. OHSU scientists first to grow liver stem cells in culture, demonstrate therapeutic benefit
10. Scientists Pinpoint How Deep Brain Stimulation Eases OCD
11. Scientists make older adults less forgetful in memory tests
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists identify gene that is consistently altered in obese individuals
(Date:5/25/2016)... ... 25, 2016 , ... Today Omega Institute, a leading destination for yoga education ... training opportunities in the growing field of yoga therapy . Yoga therapy ... with specific health issues—including injuries, illnesses, and temporary or chronic health conditions. , “Yoga ...
(Date:5/25/2016)... ... May 25, 2016 , ... DKT International, one ... developing world, is pleased to release their 2015 global impact data. In 2015, ... almost 14,000 maternal deaths and 3.8 million unsafe abortions across 21 countries worldwide. ...
(Date:5/25/2016)... Coral Gables, FL (PRWEB) , ... May 25, ... ... in its Cross Benefit Clearinghouse supporting the real time adjudication of medical service ... Urgent Care providers using their current medical claims management software. The TransactRx Cross ...
(Date:5/25/2016)... SAN FRANCISCO, CA (PRWEB) , ... May 25, 2016 , ... ... the School of Nursing and Health Professions. She will lead a team of more ... Leadership Team. Baker will begin her role as dean in late August. , Baker ...
(Date:5/25/2016)... ... May 25, 2016 , ... Laser Skin & ... turn back the hands of time of female aging. The Juliet™ ... Women with symptoms such as leakage, laxity, itchiness and pain have reported real relief ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... Mass. , May 24, 2016  NxStage Medical, ... technology company focused on advancing renal care, today announced ... plans to participate in the following schedule of investor ... be made available at http://ir.nxstage.com/ . ... Jefferies Healthcare Conference NY, NY           Friday, June ...
(Date:5/24/2016)... HONG KONG , May 24, 2016 /PRNewswire/ ... primer stent de doble terapia del mundo, introduce ... fístula arteriovenosa. OrbusNeich, una compañía global ... cambian las vidas, ha expandido su cartera incluyendo ... catéteres balón JADE™ y Scoreflex™ PTA son los ...
(Date:5/24/2016)... AMSTERDAM , May 24, 2016 ... met elkaar verbindt, zodat zij collectief patiënten kunnen behandelen, ... Dat is het idee achter de nieuwe en revolutionaire ... aanvoering van de Nederlandse vaatchirurg dr. Hans Flu en ... MDLinking app, die inmiddels beschikbaar is, wordt op dinsdag ...
Breaking Medicine Technology: