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Scientists identify gene responsible for statin-induced muscle pain
Date:11/27/2007

o statin-induced damage.

These three complementary experiments demonstrate that atrogin-1 has a fundamental role in statin-induced toxicity, notes Lecker. Future experiments will be aimed at understanding how statins turn on the atrogin-1 response in muscle, and in ascertaining what transpires in muscle following atrogin-1 activation that leads to muscle damage and atrophy. The hope is that eventually patients will be able to glean statins positive benefits to cholesterol metabolism and reduction of cardiovascular events while being spared accompanying muscle toxicities.


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Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

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