Scientists identify gene responsible for statin-induced m... ( We learned that atrogin-1 is rapidly...)

Scientists identify gene responsible for statin-induced muscle pain

Date:11/27/2007

We learned that atrogin-1 is rapidly turned on in wasting muscle, explains Lecker, who is an investigator in the Division of Nephrology at BIDMC and Assistant Professor of Medicine at HMS. Muscle wasting occurs in a large number of disease states, including cancer, AIDS, and kidney disease and can also occur when muscles are underused due to injury or lack of exercise. In the absence of atrogin-1 activation, he adds, muscle atrophy is diminished.

Since this initial discovery, atrogin-1 has been found in every existing model of muscle wasting, prompting Lecker and Sukhatme to investigate whether cholesterol-lowering statins might also be turning on this gene.

We reasoned that since atrogin-1 plays a key role in the development of wasting in skeletal muscle, it might also mediate part of [patients] sensitivity to statins, the authors write.

They proceeded to conduct three separate experiments to test this hypothesis. They first examined the expression of the atrogin-1 gene in biopsies of 19 human quadricep muscles from five control patients, six patients with muscle pain who were not being treated with statins and eight patients with muscle pain/damage who were using statins. Their results showed that atrogin-1 expression was significantly higher among the statin users.

Next, the scientists studied statins effects on cultured muscle cells treated with various concentrations of lovastatin. Compared with control samples, the lovastatin-treated cells became progressively thinner and more damaged. But remarkably, say the authors, the cells lacking the atrogin-1 gene were resistant to statins deleterious effects.

Finally, the authors tested the drug in zebrafish. And, they showed that just as in mammalian muscle cell culture, lovastatin led to muscle damage, even at low concentrations; as the concentration was increased, so too was the damage. And, once again, they observed that fish lacking the atrogin-1 gene were resistant t
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3
Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds

Post Your Comments:

(Date:12/15/2009)... -- Vitech Systems Group, a leading provider of ... announced today that it has completed a major ... Actors Guild-Producers Pension & Health Plans (SAG-PH). ,, ... to SAG-PH call center personnel in Burbank, Ventura ... Vitech,s V3 Benefits Administration System which consolidated data ...

(Date:12/15/2009)... have really been in trouble, expert says , , TUESDAY, ... pandemic H1N1 swine flu has revealed serious flaws in ... a new report says. , The report, prepared by ... Johnson Foundation, also finds the dire economy has strained ... H1N1 outbreak is the latest in a series of ...

(Date:12/15/2009)... delivered ,, WASHINGTON, Dec. 15 ... that healthcare reform does not override the prostate ... in 37 states. ,, Prostate cancer screening is ... and individuals who are identifiable as high risk, ... a family history of prostate cancer. The American ...

(Date:12/15/2009)... BERWYN, Pa., Dec. 15 4R Systems, ... supply chain solutions which help retailers significantly increase ... chain decisions, announced today that The Vitamin Shoppe ... 2008. ,, "4R,s store and DC inventory solutions ... inventory efficiency and in-stocks over the last two ...

(Date:12/15/2009)... --The following are the remarks by Lanny ... division, at the Medicare Fraud Strike Force press ... you for the enormous effort everyone at HHS ... Together, our Departments have and will continue to ... tremendous progress in fighting Medicare fraud in South ...

Breaking Medicine News(10 mins):Health News:Screen Actors Guild - Producers Pension & Health Plans Live on New CRM Solution 2 Health News:Serious Gaps Revealed in U.S. Response to Health Emergencies 2 Health News:Serious Gaps Revealed in U.S. Response to Health Emergencies 3 Health News:Men's Health Network Calls on Congress to Complete President Obama's Promise on Health Care Reform 2 Health News:4R's Profit Optimizing Inventory Solutions Helps The Vitamin Shoppe Drive Increased Productivity and Performance 2 Health News:4R's Profit Optimizing Inventory Solutions Helps The Vitamin Shoppe Drive Increased Productivity and Performance 3 Health News:4R's Profit Optimizing Inventory Solutions Helps The Vitamin Shoppe Drive Increased Productivity and Performance 4 Health News:Remarks by Lanny A. Breuer, Assistant Attorney General for the Criminal Division, at the Medicare Fraud Strike Force Press Conference 2 Health News:Remarks by Lanny A. Breuer, Assistant Attorney General for the Criminal Division, at the Medicare Fraud Strike Force Press Conference 3

[0] Screen Actors Guild - Producers Pension & Health Plans Live on New CRM Solution [0] Serious Gaps Revealed in U.S. Response to Health Emergencies [1] Men's Health Network Calls on Congress to Complete President Obama's Promise on Health Care Reform [1] 4R's Profit Optimizing Inventory Solutions Helps The Vitamin Shoppe Drive Increased Productivity and Performance [1] Remarks by Lanny A. Breuer, Assistant Attorney General for the Criminal Division, at the Medicare Fraud Strike Force Press Conference

... in an upcoming issue of the World Health Organisation (WHO) ... issue of border control, and the need for coherent and ... pandemic . The report comes after the recent confirmation ... (HN51) in Northern Sumatra: although the outbreak was contained by ...

... Oct. 10 CBIZ, Inc. (NYSE: CBZ ) has,scheduled ... a.m.,(ET) to discuss the Company,s financial results for the third-quarter ... the,market opens the morning of October 25, 2007. At that ... Company,s web site at http://www.cbiz.com . The call ...

... afternoon Governor,Arnold Schwarzenegger held a press conference ... the state legislature aimed at producing,reforms to ... the,Employment Policies Institute issued the following statement:, ... not solve California,s,health care crisis," said Jill ...

... and Hundreds of Other Prizes Just ... for Doing Something Healthy, PHILADELPHIA, ... their well-being, the region,s leading,health insurer, Independence Blue Cross, announces No ... better health. No Pay Getaway invites eligible members who get ...

... Oct. 10 Blue Cross and Blue Shield,of ... approval for all,of its 2008 Medicare Advantage BlueMedicare(SM) ... Service (PFFS) product, expansion of PPO and,HMO products ... drug plan,benefits. (Logo: http://www.newscom.com/cgi-bin/prnh/20000427/BLUELOGOA ) ...

... suggests it boosts blood pressure, damages cells , WEDNESDAY, ... lead exposure accelerated chronic kidney disease in rats by ... cellular damage, U.S. researchers report. , Previous studies in ... high blood pressure, atherosclerosis (hardening of the arteries), kidney ...

Other Medicine News:Health News:Report highlights inadequate pandemic planning as a threat to EU security 2 Health News:CBIZ Webcasts Third-Quarter 2007 Conference Call 2 Health News:Independence Blue Cross Announces 'No Pay Getaway' Promotion Designed to Encourage Healthy Behaviors 2 Health News:Independence Blue Cross Announces 'No Pay Getaway' Promotion Designed to Encourage Healthy Behaviors 3 Health News:Blue Cross and Blue Shield of Florida Receives Approval for Medicare Advantage BlueMedicare Plans in 2008 2 Health News:Blue Cross and Blue Shield of Florida Receives Approval for Medicare Advantage BlueMedicare Plans in 2008 3

Report highlights inadequate pandemic planning as a threat to EU security CBIZ Webcasts Third-Quarter 2007 Conference Call EPI Says, California Health Care Reform Bill is Misguided Independence Blue Cross Announces 'No Pay Getaway' Promotion Designed to Encourage Healthy Behaviors Blue Cross and Blue Shield of Florida Receives Approval for Medicare Advantage BlueMedicare Plans in 2008 Low Lead Exposures Can Hurt Kidneys

(Date:12/15/2009)... New York Times article ... Division," illustrates an internal renal community reimbursement debate ... be deprived of their life-saving immunosuppressive medications beyond ... Congress is poised to approve this urgent transplant ... kidney recipients, behind-the-scenes debate continues within the renal ...

(Date:12/15/2009)... Reportlinker.com announces that a ... in its catalogue: ,, Systemic ... and Market Forecasts to 2015 ... Systemic Lupus Erythematosus - Drug Pipeline ... ,, Summary ,, GlobalData, ...

(Date:12/15/2009)... YORK, Dec. 15 Reportlinker.com ... report is available in its catalogue: ... Therapeutics - Market Forecasts to 2015, ... Analysis ,, http://www.reportlinker.com/p0168102/The-Future-of-HIV-Therapeutics---Market-Forecasts-to-2015-Competitive-Benchmarking-Product-Pipeline-and-Deals-Analysis.html ... author has released its latest research ...

[0] AST Concerned That Kidney Transplant Patients May Suffer Politics As Usual in Capitol Hill Health Care Reform Debate [0] Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 [0] Reportlinker Adds The Future of HIV Therapeutics - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis

... Presented at the 31st European Cystic Fibrosis Conference ... Republic, June 12 /PRNewswire/,-- PTC Therapeutics, Inc. (PTC) ... PTC124 in cystic fibrosis (CF). Results from an ... oral PTC124 treatment in adult,patients with nonsense-mutation-mediated CF ...

... June 12 Cardiogenesis,Corporation (Pink Sheets: CGCP), ... revascularization, today announced a scientific presentation,that describes ... combining,transmyocardial revascularization (TMR) with autologous bone marrow ... Revascularization Combined,with Concentrated Autologous Stem Cells," is ...

Other Medicine Technology:PTC Therapeutics Announces Data from Additional Clinical Studies of PTC124 in Cystic Fibrosis Confirming Activity 2 PTC Therapeutics Announces Data from Additional Clinical Studies of PTC124 in Cystic Fibrosis Confirming Activity 3 PTC Therapeutics Announces Data from Additional Clinical Studies of PTC124 in Cystic Fibrosis Confirming Activity 4 PTC Therapeutics Announces Data from Additional Clinical Studies of PTC124 in Cystic Fibrosis Confirming Activity 5 Cardiogenesis Announces Preliminary Clinical Results With the PHOENIX System Combining TMR + Stem Cells 2 Cardiogenesis Announces Preliminary Clinical Results With the PHOENIX System Combining TMR + Stem Cells 3 Cardiogenesis Announces Preliminary Clinical Results With the PHOENIX System Combining TMR + Stem Cells 4

PTC Therapeutics Announces Data from Additional Clinical Studies of PTC124 in Cystic Fibrosis Confirming Activity Cardiogenesis Announces Preliminary Clinical Results With the PHOENIX System Combining TMR + Stem Cells

The Surgifresh mini has the same rugged construction as the Plume-inator. It is the ideal size for operating room, clinic and office settings. This unit includes a filter test button, hospital grade ...

A system for the removal and filtration of laser and surgical smoke....

The FreedomAire Surgical Helmet System is a lightweight, comfortable helmut system with superior air flow, and a removable motor module that lifts off for easy cleaning....

...

Medicine Products:

Surgifresh® Mini SAFE® System Surgical Smoke Evacuation System FreedomAire Surgical Helmet System Round Stainless Steel Moulded Ground

Scientists identify gene responsible for statin-induced m...( We learned that atrogin-1 is rapidly...),Health