Navigation Links
Scientists identify 'gatekeepers' of breast cancer transition to invasive disease
Date:5/5/2008

appears to play a critical role in myoepithelial cell differentiation. Perturbation of key mediators of these signaling pathways led to a loss of myoepithelial cells and a progression to invasion.

Here, we show that a key event of tumor progression is the disappearance of the myoepithelial cell layer due to defective myoepithelial cell differentiation regulated by intrinsic and microenvironment signals. Thus, myoepithelial cells can be considered gatekeepers of the in situ to invasive carcinoma transition; understanding the pathways that regulate their differentiation may open new venues for cancer therapy and prevention, offers Dr. Polyak.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists at Yale provide explanation for how cancer spreads
2. Brookhaven scientists explore brains reaction to potent hallucinogen
3. Scientists Discover How Stomach Tumors Form
4. U.S. Scientists Receive Japan Prize on April 23, 2008
5. Scientists discover a mechanism that can send cells on the road to cancer
6. Scientists identify novel way to prevent cardiac fibrosis
7. Scientists Explore Human Gene Pool With Help From Microsoft Research
8. Scientists obtain anticancer medicines from the elecampe, a wild plant growing in the Mediterranean
9. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
10. With annual deaths from malaria on the rise: Scientists ask where is all the money going?
11. Stem cells and cancer: Scientists investigate a fine balancing act
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The U.S. Pharmacopeial Convention is pleased to announce ... Services at North Carolina State’s College of Veterinary Medicine ... Award for Distinguished Volunteer Service—the organization’s highest award. ... of volunteer experts to direct its work to improve ...
(Date:1/22/2015)... January 22, 2015 Woodloch Pines, an ... been selected by TripAdvisor as the number one best large ... best in the world for their annual Travelers’ Choice Awards. ... community . The website is home to millions of unbiased ...
(Date:1/22/2015)... TX (PRWEB) January 22, 2015 The Incredible ... Bodybuilder Ben Pakulski to increase lean muscle by up to ... has caught the attention of HealthyandFitZone.com’s Stan Stevenson, prompting an ... that it is a step-by-step, scientific diet formula that allows ...
(Date:1/22/2015)... The federal court overseeing thousands of vaginal mesh ... District of West Virginia has upheld a $2 million verdict ... trial. In an Order dated January 21st, the Court denied ... C.R. Bard had not proven a miscarriage of justice. (Cisson ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Autocarinsurancebest.com has released ... purchasing a commercial auto insurance policy . , Auto ... their vehicles. It is no longer necessary to call an ... are now available online on a single website: http://autocarinsurancebest.com/ ...
Breaking Medicine News(10 mins):Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 3Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 4Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Commercial Auto Insurance Provides Several Important Features! 2
... mental condition and reaction to physical discomfort , , FRIDAY, ... brains of people with depression kick into overdrive and ... shows. , The November issue of the Archives ... that during the painful experience, activity then decreases in ...
... runs out on,the Bush Administration, key US officials are ... Global Fund to Fight AIDS, Tb,and Malaria., US ... in India,where they have joined forces with representatives of ... in grants for health,programs around the world., The ...
... PHILADELPHIA, Nov. 7 Lippincott Williams & Wilkins ... Neuroscience Nurses to,publish the Journal of Neuroscience Nursing ... part of Wolters Kluwer Health, a,leading provider of ... in medicine, nursing, allied health,pharmacy and the pharmaceutical ...
... Education Program for People Living with Diabetes ... Returns to San Diego, ... lunch and health fair will be held November 22 from,8:30 a.m. to ... experts in diabetes care to people with all,types of diabetes, those at ...
... three who had hernia surgery showed almost twice the risk ... had not undergone the surgery, according to a study by ... the College of Physicians and Surgeons. The study included ... Medicaid system between 1999 and 2001 who had surgery performed ...
... KENILWORTH, N.J., Nov. 7 Schering-Plough,Corporation (NYSE: ... for analysts,and portfolio managers being held on Monday, ... Tom Koestler, Ph.D., executive vice,president and president, Schering-Plough ... the meeting. The primary purpose of the,meeting is ...
Cached Medicine News:Health News:Depression Heightens Sensitivity to Pain 2Health News:Obama Could Inherit Weaker Global Health Fund 2Health News:Lippincott Williams & Wilkins Selected as Publisher of the Journal of Neuroscience Nursing 2Health News:Lippincott Williams & Wilkins Selected as Publisher of the Journal of Neuroscience Nursing 3Health News:Centennial Taking Control of Your Diabetes Conference Returns to San Diego to Bring Answers, Advocacy and Hope 2Health News:General anesthesia for hernia surgery in children and risk of later developmental problems 2
(Date:1/23/2015)... baseball,s all-time hits leader, is the new spokesperson for the ... has announced. "Pete,s a Hall of Famer in ... board with Myoflex," said Ducere Pharma Chief Executive Officer ... known across all generations. The passion and intensity that Pete ...
(Date:1/23/2015)... , Jan. 23, 2015  Lixte Biotechnology Holdings, Inc. (OTCQB: LIXT), ... I trial of Lixte,s lead compound, LB‑100, is being conducted, ... John S. Kovach , M.D., the founder and President ... be completed at a single site. Accrual of patients, however, ...
(Date:1/23/2015)... (NYSE: MNK ) announced today that its ... The open-ended authorization permits the company to repurchase up ... "Funding additional initiatives and seeking attractive business ... pursue a range of focused growth strategies," said ...
Breaking Medicine Technology:Pete Rose bets on Myoflex to relieve aches and pains 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 3Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4
... DURECT Corporation (Nasdaq: DRRX ) announced today that it has secured a ... million of its registered common stock to Azimuth Opportunity Ltd. for a ... $50 million facility.  DURECT did not pay a commitment fee or ... , , ...
... WASHINGTON , July 1 Hanger Orthopedic ... efforts in response to the January 12th ... alliance of U.S.-based international development and humanitarian nongovernmental organizations. ... Orthopedic Group was nominated by Physicians for Peace, an ...
Cached Medicine Technology:DURECT Corporation Secures $50 Million Committed Equity Financing Facility 2DURECT Corporation Secures $50 Million Committed Equity Financing Facility 3Hanger Orthopedic Group Honored for its Charitable Relief Efforts in Haiti by InterAction 2Hanger Orthopedic Group Honored for its Charitable Relief Efforts in Haiti by InterAction 3
... Estrone Sulfate (E1S) is the most abundant ... as normal men [1,2]. Estrone Sulfate is ... and has a longer half-life in blood ... generally parallel those of estrone and estradiol, ...
Helmer's Horizon Series line of refrigerators are designed specifically for the cost conscious buyer. This line offers outstanding performance, quality, and the features you need to ensure the safety...
... presents the i.Series refrigerator ... solutions for the blood ... features than ever before, ... are at the forefront ...
... Designed for the precise requirements ... Thermo Forma Blood Bank Equipment meets ... American National Red Cross (ANRC) and ... standards. Refrigerators, storage freezers, and platelet ...
Medicine Products: