Navigation Links
Scientists identify brain's 'molecular memory switch'
Date:3/28/2013

or instance, they can land on the ceiling and detect that the fruit in your fruit bowl has gone off before you can."

"In experiments whereby we tested the flies' learning and memory ability, involving two odours presented to the flies with one associated with a mild shock, we found that around 90 per cent were able to learn the correct choice remembering to avoid the odour associated with the shock. Five lessons of the odour with punishment made the fly remember to avoid that odour for between 24 hours and a week, which is a long time for an insect that only lives a couple of months."

By localising the function of the key molecules CASK and CaMKII to the flies' equivalent brain area to the human hippocampus, the team found that the flies lacking these genes showed disrupted memory formation. In repeat memory tests those lacking these key genes were shown to have no ability to remember at three hours (mid-term memory) and 24 hours (long-term memory) although their initial learning or short-term memory wasn't affected.

Finally, the team introduced a copy of the human CASK gene it is 80 per cent identical to the fly CASK gene into the genome of a fly that completely lacked its own CASK gene and was therefore not usually able to remember. The researchers found that flies which had a copy of the human CASK gene could remember like a normal wildtype fly.

Dr Hodge, from the University's School of Physiology and Pharmacology, said: "Research into memory is particularly important as it gives us our sense of identity, and deficits in learning and memory occur in many diseases, injuries and during aging".

"CASK's control of CaMKII 'molecular memory switch' is clearly a critical step in how memories are written into neurons in the brain. These findings not only pave the way for to developing new therapies which reverse the effects of memory loss but also prove the compatibility of Drosophila to model these diseases in
'/>"/>

Contact: Caroline Clancy
caroline.clancy@bristol.ac.uk
44-011-792-88086
University of Bristol
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Dana-Farber Scientists find potential loophole in pancreatic cancer defenses
2. York scientists discover driving force behind prostate cancer
3. Scientists and public school teachers team up to transform science education
4. Scientists identify gene that is consistently altered in obese individuals
5. Most men with erectile dysfunction remain untreated, say US scientists
6. Scientists investigate potential markers for a response to sunitinib in patients with metastatic RCC
7. Scientists ID Antibody That Might Boost Cancer Therapy
8. Scientists Report Clues to Flu Shots Effectiveness
9. Scientists discuss relationship between abortion and violence against women
10. A*STAR scientists discover switch critical to wound healing
11. Scientists uncover source of ovarian stem-like cells prone to give rise to ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... April 24, 2014 Pregnant immigrants from Sub-Saharan ... increased monitoring during pregnancy, according to new research ... today in the British Journal of Obstetrics ... and eclampsia rates among immigrants and native-born women ... (Ontario), Denmark, Sweden, Spain (Catalonia and Valencia) and ...
(Date:4/23/2014)... The American Society for Radiation Oncology (ASTRO) has ... Radiation Therapy for Endometrial Cancer: An ASTRO Evidence-Based ... therapy in the treatment of endometrial cancer. The ... 2014 issue of Practical Radiation Oncology ... The full-length guideline is available as an open-access ...
(Date:4/23/2014)... the gastro-intestinal tract has long been considered to be ... Sahlgrenska Academy have used refined microscopic techniques that indicate ... of the gastro-intestinal tract is only as large as ... The digestive tract, which passes from the mouth through ... length of about 5 meters in a normal adult, ...
(Date:4/23/2014)... of probiotics, antioxidants and other nutritional compounds, more and ... is getting in on the action. But legitimate skepticism ... industry is responding with clinical research to shore up ... Chemical & Engineering News (C&EN), the weekly news ... Bomgardner, a senior editor at C&EN, writes that about ...
(Date:4/23/2014)... Parents and physicians concerned about an increase in adolescents, ... breathe a sigh of relief. According to a new ... worth of data from states with and without medical ... increased use among adolescents. The study is published online ... Adolescent Health . , "Any time a state ...
Breaking Medicine News(10 mins):Health News:Pregnancy complications may be more common in immigrants from certain regions 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 3Health News:The surface area of the digestive tract 'only' as large as a studio apartment 2Health News:RI Hospital physician: Legalizing medical marijuana doesn't increase use among adolescents 2
... nitrogen-containing bisphosphonate (N-BP) cancer drugs, used to relieve bone ... has been almost entirely unknown. Researchers writing in BioMed ... used ,barcoded, yeast mutants to identify new biological processes ... opportunities for the development of new anticancer drugs. ...
... LOS ANGELES, Sept. 9 In commemoration of the first ... Red Cross of Greater Los Angeles will host three 2-hour volunteer orientations ... volunteers will receive a tour of the chapter,s new state of the ... Cross, response to the recent California wildfires. , , ...
... WASHINGTON, Sept. 9 Congressman Chaka Fattah (D-PA), a strong ... conclusion of President Obama,s address tonight to Congress and the nation: ... The time to act is now. We have been talking and ... of this 111th Congress. The American people have already voted: In ...
... , INDIANAPOLIS, Sept. 9 WellPoint, Inc. (NYSE: ... Medicare Advantage and 2010 Medicare Part D health benefit plans effective Oct. ... Medicare Part D health benefit plans on Nov. 15, 2009 for the ... Medicare and Medicaid Services (CMS) has determined that WellPoint has corrected deficiencies ...
... , DENVER, Sept. 9 DaVita Inc. (NYSE: ... for those diagnosed with chronic kidney disease (CKD), supports dialysis patients, ... standards and social circumstances. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20020729/DAVITALOGO ... your everyday student at Hollywood High School in Los Angeles, CA ...
... infection known as Trichomonas vaginalis is associated ... study published online September 9 in the Journal ... Stark, ScD, of the department of epidemiology at the ... conducted a case-control study nested within the Physicians, Health ...
Cached Medicine News:Health News:Red Cross Participates in September 11th National Day of Service and Remembrance 2Health News:Statement on WellPoint's Re-Entry into Medicare Market 2Health News:DaVita's Patient-Centric Modalities Offer Students with Kidney Disease More Choices 2Health News:JNCI news brief: STD confirmed to be associated with increased risk of prostate cancer 2
(Date:1/15/2014)...  Celsion Corporation (the "Company") (NASDAQ: CLSN ) ... investors to purchase an aggregate of approximately $15 million ... direct offering, led by a dedicated health care fund. ... with these investors pursuant to which the Company agreed ...
(Date:1/15/2014)... WORTH, Texas , Jan. 15, 2014  Humberto C. ... Dermatology Achievement Award" from the Journal of Drugs ... Aesthetic & Clinical Conference (ODAC). The event is January 17-20, ... Florida . The ODAC ...
(Date:1/15/2014)... GARDENS, Fla. , Jan. 15, 2014  In an unprecedented effort ... and TB in ambulances and other transport vehicles, an advanced and ... by rescue personnel for the first time. In ... contact with these deadly pathogens, West Palm Beach ...
Breaking Medicine Technology:Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4Superbugs No Longer Ride In Rescue Vehicles 2
... Sept. 26, 2011 Luminex Corporation (NASDAQ: ... xMAP Europe 2011, its annual European multiplexing technology symposium, ... The event will feature scientific sessions, workshops, discussion groups, ... around the world who are performing groundbreaking work in ...
... Sept. 26, 2011 Safely storing prescription medications ... other prescription holders. Now, an innovative new device ... dangerous medications—in a small, convenient and more portable ... Developed by CAP-N-LOCK, LLC., The ...
Cached Medicine Technology:Luminex Corporation Hosts Ninth Annual Planet xMAP Europe in Vienna 2Luminex Corporation Hosts Ninth Annual Planet xMAP Europe in Vienna 3Luminex Corporation Hosts Ninth Annual Planet xMAP Europe in Vienna 4New Combination Locking Cap Designed to Protect Children and Teens From Prescription Medications 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: