Navigation Links
Scientists identify a key molecule that blocks abnormal blood vessel growth in tumors
Date:9/21/2011

TAMPA, Fla. (Sept. 21, 2011) A new and better understanding of blood vessel growth and vascular development (angiogenesis) in cancer has been made possible by research carried out by a team of scientists from Moffitt Cancer Center, the University of Florida, Harvard University, Yale University and the Children's Hospital of Los Angeles.

The research team published the results of their investigation in a recent issue of Proceedings of the National Academy of Sciences.

"Vascular development is a fundamental biological process that is tightly controlled by both pro-and anti-angiogenic mechanisms," said Edward Seto, Ph.D., a co-author of the study and professor and chairman of the Department of Molecular Oncology at Moffitt. "Physiological angiogenesis occurs in adults only under specific settings. Excess angiogenesis contributes to a variety of diseases, including cancer. In cancer, vascular endothelial growth factor (VEGF) is commonly overproduced."

The goal of the research was to determine how angiogenesis is regulated by positive and negative biological activities.

"Understanding the biological principles that direct vascular growth has important clinical implications because cancers are highly vascularized," concluded Seto.

This meant seeking a better understanding of the relationship between the chromatin insulator binding factor CTCF and how it regulates VEGF expression.

"At the heart of vascular development is VEGF which, in precise doses, is an important stimulator of normal blood vessel growth," explained Seto. "However, VEGF probably the most important stimulator of normal and pathological blood vessel growth is regulated by a number of factors."

According to Seto, the study suggests that CTCF can block VEGF from being activated. Therefore, targeting CTCF may be an effective way to fine tune VEGF and control angiogenesis. The potential to manipulate CTCF opens a window to regulate VEGF and subsequently, the potential to manage angiogenesis and cancer.

"The real significance of this work has been apparent in experiments done at the University of Florida and at Harvard University, where our colleagues used mouse models to demonstrate that depletion of CTCF produces excess angiogenesis in animals," explained Seto. "Like finding a small key piece in a giant puzzle, it's truly exciting."


'/>"/>

Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... The Honolulu ... fully redesigned website, which launched October 17, 2016, features comprehensive information regarding a ... easy-to-navigate layout. Visitors and patients can discover the latest clinical dermatology treatments for ...
(Date:12/7/2016)... ... December 07, 2016 , ... The medical profession is well aware that heart ... major study analyzing heart attacks among 138,602 people recorded a 35% higher number of ... would all agree of course–no time of year is a good time for a ...
(Date:12/7/2016)... ... ... Road To Restoration”: an informative and enlightening book for those who believe that ... “The Road To Restoration” is the creation of published author, Thomas Fitzhugh Sheets, seventy-one-year-old ... you could reach out for, and grab, on the old carousels. If you ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... fifth annual Business Architecture Innovation Summit in Reston, VA on March 21-22, 2017. ... will share a range of experiences from a cross-section of industries such as ...
(Date:12/6/2016)... Korea (PRWEB) , ... December 06, 2016 , ... ... Inc. have agreed to collaborate in developing a vaccine against the Middle East ... a vaccine can be available in South Korea for emergency deployment in the ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... 2016  Organovo Holdings, Inc. (NASDAQ: ... on delivering scientific and medical breakthroughs using its ... Chief Executive Officer Keith Murphy is ... 14, 2016 at 1:00 p.m. Eastern Time (ET). ... familiar with the Company, an informational video and ...
(Date:12/7/2016)... , Dec. 7, 2016  Lannett Company, Inc. (NYSE: ... the BMO Capital Markets 2016 Prescription for Success Healthcare Conference on ... hotel in New York City . ... participating at the Guggenheim Securities 4 th Annual Boston Healthcare ... hotel. ...
(Date:12/6/2016)... , Dec. 6, 2016  "Blood Tests replace ... announced ....." The Diagnostic, Monitoring and Screening ... cancer diagnostics is occurring using in vitro blood ... company with impressive backing, has announced a single ... is moving faster than the market. New technology ...
Breaking Medicine Technology: