Navigation Links
Scientists identify KRAS rearrangements in metastatic prostate cancer
Date:4/2/2011

ORLANDO, Fla. Scientists have uncovered a genetic characteristic of metastatic prostate cancer that defines a rare sub-type of this disease. These findings are published in Cancer Discovery, the newest journal of the American Association for Cancer Research, which will debut at the AACR 102nd Annual Meeting 2011, held April 2-6.

Arul M. Chinnaiyan, M.D., Ph.D., an investigator of the Howard Hughes Medical Institute and director of the Michigan Center for Translational Pathology, and colleagues identified an oncogenic gene fusion of KRAS, one of the most studied and well-known oncogenes in a metastatic prostate cancer cell line.

Like most metastatic disease, metastatic prostate cancer has a grim prognosis. As scientists learn more about the genetic characteristics of this disease, they may be able to work backward and accurately predict which early-stage prostate cancers will be more aggressive and thus require additional therapy and management.

"Right now, we can identify the presence of prostate cancer but not accurately predict which of these cancers will have a poor prognosis," said Chinnaiyan. "Although prostate cancer is a leading cause of cancer-related death, we need better prognostic information to separate the slow growing tumors from the more aggressive ones."

Chinnaiyan compared the identification of the KRAS gene in metastatic prostate cancer to the work that has been previously done in breast cancer, where scientists now recognize that breast cancer comes in multiple subtypes and requires different treatment strategies.

"The more we know about the disease biologically, the better we'll be able to treat it," said Chinnaiyan.

Currently, there are no treatments that block the KRAS oncogene, but several are under development that target components of the KRAS signaling pathway.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Smithsonian scientists find declining rainfall is a major influence for migrating birds
2. Scientists devise targeted therapy strategy for rare form of childhood cancer
3. Scientists Create Autism-Like Traits in Mice
4. Scientists find candidate for new TB vaccine
5. Scientists find a key to maintaining our DNA
6. Scientists ID possible biomarker to gauge Alzheimers prognosis, effect of therapies
7. Scientists identify molecule that can increase blood flow in vascular disease
8. Nottingham scientists identify trigger in cat allergy
9. MIT scientists identify new H1N1 mutation that could allow virus to spread more easily
10. Scripps Research and MIT scientists discover class of potent anti-cancer compounds
11. Scientists find key mechanism of childhood respiratory disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... March 29, 2017 , ... Full Contact K9, an Atlanta-based dog ... Protect Law that assists dog owners in creating legally-enforceable pet trusts for their ... the natural next step to protect their new companion. Says Evan Dunbar, CEO of ...
(Date:3/29/2017)... ... March 30, 2017 , ... Youth Futures International (YFI) premiered its Serve, ... high school and college students who have participated in the program every summer. ... is now accepting applications for enrollment. Visit http://www.ghana.yfiexperience.org to learn more. ...
(Date:3/29/2017)... ... March 29, 2017 , ... Wells ... for attending prescribers at the upcoming World Congress, in Hollywood Florida April 6-8, ... been recognized as the visionary leader in the training of physicians, scientists, and ...
(Date:3/29/2017)... ... March 29, 2017 , ... Based on research from Guardian’s ... face in trying to balance both short-term and long-term benefits demands. Are ... the growing complexity, companies are finding that the short-term strategies used to control ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... (GRMA) is growing as it continues developing an ANSI-approved, consensus-based American National ... organization, which plans to publish the first ANSI-approved GMP standard for dietary ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... and Markets has announced the addition of the "South Korean Proton ... report to their offering. ... The South Korean Proton Therapy Market is expected to almost triple ... Therapy Market for South Korea was valued at ... plays an important role in delivering comprehensive cancer care to children and ...
(Date:3/29/2017)... 2017  Experts in the field in alcohol ... Soberlink Systems  as a model for recovery through ... early 2017, concluded that remote blood alcohol monitoring ... recovery." The findings of the expert ... detail a range of variables that are commonplace ...
(Date:3/29/2017)... , March 29, 2017 Optometrists have ... as the highest standard in quality and care ... introduces its objective Wavefront-driven refraction technologies and process ... This enables an unprecedented level of refraction and ... vision relegated to Topgun Navy fighter pilots, but ...
Breaking Medicine Technology: