Navigation Links
Scientists identify KRAS rearrangements in metastatic prostate cancer
Date:4/2/2011

ORLANDO, Fla. Scientists have uncovered a genetic characteristic of metastatic prostate cancer that defines a rare sub-type of this disease. These findings are published in Cancer Discovery, the newest journal of the American Association for Cancer Research, which will debut at the AACR 102nd Annual Meeting 2011, held April 2-6.

Arul M. Chinnaiyan, M.D., Ph.D., an investigator of the Howard Hughes Medical Institute and director of the Michigan Center for Translational Pathology, and colleagues identified an oncogenic gene fusion of KRAS, one of the most studied and well-known oncogenes in a metastatic prostate cancer cell line.

Like most metastatic disease, metastatic prostate cancer has a grim prognosis. As scientists learn more about the genetic characteristics of this disease, they may be able to work backward and accurately predict which early-stage prostate cancers will be more aggressive and thus require additional therapy and management.

"Right now, we can identify the presence of prostate cancer but not accurately predict which of these cancers will have a poor prognosis," said Chinnaiyan. "Although prostate cancer is a leading cause of cancer-related death, we need better prognostic information to separate the slow growing tumors from the more aggressive ones."

Chinnaiyan compared the identification of the KRAS gene in metastatic prostate cancer to the work that has been previously done in breast cancer, where scientists now recognize that breast cancer comes in multiple subtypes and requires different treatment strategies.

"The more we know about the disease biologically, the better we'll be able to treat it," said Chinnaiyan.

Currently, there are no treatments that block the KRAS oncogene, but several are under development that target components of the KRAS signaling pathway.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Smithsonian scientists find declining rainfall is a major influence for migrating birds
2. Scientists devise targeted therapy strategy for rare form of childhood cancer
3. Scientists Create Autism-Like Traits in Mice
4. Scientists find candidate for new TB vaccine
5. Scientists find a key to maintaining our DNA
6. Scientists ID possible biomarker to gauge Alzheimers prognosis, effect of therapies
7. Scientists identify molecule that can increase blood flow in vascular disease
8. Nottingham scientists identify trigger in cat allergy
9. MIT scientists identify new H1N1 mutation that could allow virus to spread more easily
10. Scripps Research and MIT scientists discover class of potent anti-cancer compounds
11. Scientists find key mechanism of childhood respiratory disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... NV (PRWEB) , ... May 02, 2016 , ... ... Pharmacy Times, has announced a new Specialty Pharmacy Patient Satisfaction Award that will ... based on the quarterly results from Zitter Health Insights’ Specialty Pharmacy Patient Satisfaction ...
(Date:5/2/2016)... ... May 02, 2016 , ... The 2016 World Ultimate & Guts Championship (WUGC) Mixed roster was ... made the cut. The WUGC is being held in London, England this year from June ... the men’s division, another gold in the women’s masters division, and a silver in the ...
(Date:5/2/2016)... ... , ... Pregnancy Awareness Month offers a great time to get familiar with ... are ready to have a baby, it’s best to get started before age becomes ... Personal Conception & Pregnancy Organizer, written for women who plan on becoming pregnant to ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... ... division of Permobil, recently completed two groundbreaking studies that determined that the adjustability ... – are critical in the prevention of pressure injuries, which are now referred ...
(Date:5/2/2016)... Washington, DC (PRWEB) , ... May 02, 2016 , ... ... “ How CMS’s Medicare Part B Payment Model Could Transform the Pharma Landscape .” ... an eye on reducing its spend on provider-administered drugs while preserving care provided to ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... April 28, 2016 TapImmune,Inc. ... innovative peptide and gene-based immunotherapeutics and vaccines for the treatment ... presenting at the 3rd Annual Growth Capital Expo ... , 2016 at Caesars Palace in Las Vegas, Nevada.  ... Wednesday, May 4 th by Dr. John N. ...
(Date:4/27/2016)... PARIS , le 27 Avril 2016 /PRNewswire/ ... chiffre d,affaires a progressé de +5% sur le ... ventes récurrentes de consommables  Croissance de ... Mauna Kea Technologies (Euronext : ... multidisciplinaire d,endomicroscopie confocale laser, annonce aujourd,hui son chiffre ...
(Date:4/27/2016)... 27, 2016   Zillion Group today ... technology platform, which specializes in live video consultation. ... digital products, Zillion enables companies to realize the ... to take control of their health. ... – including one-to-one, group and webcast scheduled or ...
Breaking Medicine Technology: