Navigation Links
Scientists generate long-sought molecular map of critical genetic machinery
Date:6/5/2014

LA JOLLA, CAJune 5, 2014A team led by researchers at The Scripps Research Institute (TSRI) has used advanced electron microscopy techniques to determine the first accurate structural map of Mediator, one of the largest and most complex "molecular machines" in cells.

Mediator is crucial for the regulation of most genes' activity and works in the cells of all plants and animals. The mapping of its structurewhich includes more than two dozen unique protein subunitsrepresents a significant advance in basic cell biology and should shed light on medical conditions involving Mediator's dysfunction, from cancer to inherited developmental disorders.

The finding demonstrates how recently developed molecular imaging methods can be applied to characterize large and important protein complexes.

"Being able to determine how these large molecular machines look, how they're organized and how they move, will be critical for a better understanding of many key processes in cells," said TSRI Associate Professor Francisco J. Asturias, the senior author of the study, which was published on June 5, 2014 by the journal Cell.

A Complex Machine

The detailed map of Mediator comes nearly 20 years after the complex was first described by Stanford University biologist Roger Kornberg and colleagues. Kornberg, whose lab members at the time included Asturias, later won a Nobel Prize for his work on the gene transcription machinery of cells.

This gene transcription machinery evolved to perform one of the most basic and routine functions in biology, namely the copying of the information encoded in the DNA of genes into portable RNA "transcripts"some of which stay and work in the cell nucleus, while others exit the nucleus and are translated into proteins.

Each cell has its own pattern of gene transcription activity, determined by a regulatory system in which Mediator plays an indispensable role. The huge Mediator compl
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Scripps Florida scientists unravel the molecular secret of short, intense workouts
2. New nanomedicine by NTU and SERI scientists to bring relief to glaucoma patients
3. Scripps Research Institute scientists win $13 million grant in AIDS vaccine effort
4. Mice with mohawks help scientists link autism to 2 biological pathways in brain
5. Temple scientists receive $11.5 million grant for heart failure research
6. TSRI scientists catch misguided DNA-repair proteins in the act
7. Scientists seek answers with space station thyroid cancer study
8. MIPT scientists develop algorithm for anti-aging remedy search
9. Scientists reveal structural secrets of enzyme used to make popular anti-cholesterol drug
10. Scientists slow brain tumor growth in mice
11. UBC scientists find new way to mobilize immune system against viruses
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists generate long-sought molecular map of critical genetic machinery
(Date:7/29/2014)... HealthDay Reporter , MONDAY, July 28, 2014 (HealthDay ... may be able to take hormone replacement therapy soon after ... to a new study. Previous studies, including the large-scale ... effects on the heart. But, many of those women were ... past menopause. In this new study, researchers wanted ...
(Date:7/29/2014)... Kelly and Zhi Sheng , assistant professors ... recently received a grant from the Commonwealth Health ... effort that may lead to new treatment approaches. , ... , The grant will fund a two-year project to ... the BRCA1 gene. This type of cancer often has ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The global ... 9,542.3 million by 2020, growing at an estimated CAGR ... new study by Grand View Research, Inc. Introduction of ... devices by the geriatric population, along with increase in ... the major drivers of this market. In addition, presence ...
(Date:7/29/2014)... July 29, 2014 On Friday, the ... declaring the week of October 12-18, 2014, as "National ... management in improving healthcare outcomes for patients. The resolution ... John Boozman (R-AR), with support by the Case Management ... to honor case management professionals for their contributions to ...
(Date:7/29/2014)... “Our years of experience with ... to insulate their homes properly simply due to ... heat transfer and conduction,” Clean Crawls says in ... released an article explaining exactly how heat ... bills. , To contact Clean Crawls for their ...
Breaking Medicine News(10 mins):Health News:Early Hormone Therapy May Be Safe for Women's Hearts 2Health News:Early Hormone Therapy May Be Safe for Women's Hearts 3Health News:Scientists to study hereditary breast cancer to find BRCA1 treatment 2Health News:Audiology Devices Market Analysis by Product (Cochlear Implants, Bone Anchored Hearing Aids, Hearing Aids, Audiometers) Expected to Reach USD 9,542.3 Million by 2020 2Health News:Audiology Devices Market Analysis by Product (Cochlear Implants, Bone Anchored Hearing Aids, Hearing Aids, Audiometers) Expected to Reach USD 9,542.3 Million by 2020 3Health News:Audiology Devices Market Analysis by Product (Cochlear Implants, Bone Anchored Hearing Aids, Hearing Aids, Audiometers) Expected to Reach USD 9,542.3 Million by 2020 4Health News:Audiology Devices Market Analysis by Product (Cochlear Implants, Bone Anchored Hearing Aids, Hearing Aids, Audiometers) Expected to Reach USD 9,542.3 Million by 2020 5Health News:Audiology Devices Market Analysis by Product (Cochlear Implants, Bone Anchored Hearing Aids, Hearing Aids, Audiometers) Expected to Reach USD 9,542.3 Million by 2020 6Health News:CMSA Supports National Case Management Week Resolution Introduced in US Senate 2Health News:What’s The Point of Insulation? Clean Crawls Explains The Dangers of Heat Transfer in Recently Released Article 2
... men generally have lower prostate specific antigen levels than men ... the PSA test may not be as good at identifying ... 2,800 men with no evidence of prostate cancer. Results showed ... across all age groups and throughout all races. A study ...
... is effective in reducing the risk of death following a ... attack // find researchers according to latest research. ,In ... reviparin on the composite outcome of death, heart attack, and ... was reduced from 11 percent of patients in the placebo ...
... broiled fish, such as tuna, may lower stroke risk ... adults 65 and older. Study participants answered food-frequency questionnaires ... years. ,Results showed 626 of the participants experienced ... broiled or baked fish one- to four-times per week ...
... with a long-acting beta2-agonist (formoterol) can actually provide significant ... high doses of inhaled steroid, say researchers according to ... of various combinations of medicine on asthma symptoms in ... were analyzed. The patients were divided into three treatment ...
... over whether hormone replacement therapy is safe and effective ... the pros and cons of this controversial therapy. ... five years. All the women studied were 50 years ... others did not.Results showed women free of menopausal symptoms ...
... The use of alternative or complementary therapies have increased ... people using // at least one form of alternative ... biofeedback, yoga, hypnosis, acupuncture, chiropractic care, and high-dose vitamins. ... their own survey taken in 1997 to the National ...
Cached Medicine News:
(Date:7/29/2014)... , July 29, 2014 Today, Frost ... Frost & Sullivan Best Practices Award for Customer ... a cloud-based platform that connects digital health application ... as providers, pharmaceutical companies, prevention and wellness companies, ... Each year, Frost & Sullivan presents ...
(Date:7/29/2014)...   , First patient begins treatment ... safety of MSB0010718C in patients with metastatic Merkel cell carcinoma ... cancer lacking effective treatments   MSB0010718C is also currently ... for the treatment of solid tumors that aims to recruit ... of Merck KGaA, Darmstadt, Germany , today ...
(Date:7/28/2014)... (NASDAQ: LMNX ) today announced financial results ... and operating highlights include the following: , ... percent increase over the second quarter of 2013. ... 9 percent increase over the second quarter of 2013.  ... which included 148 LX systems, 96 MAGPIX systems, and ...
Breaking Medicine Technology:Frost & Sullivan Commends Validic for Delivering Superior Customer Value through its mHealth Interoperability Technology Platform 2Frost & Sullivan Commends Validic for Delivering Superior Customer Value through its mHealth Interoperability Technology Platform 3Frost & Sullivan Commends Validic for Delivering Superior Customer Value through its mHealth Interoperability Technology Platform 4EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 2EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 3EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 4EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 5Luminex Corporation Reports Second Quarter 2014 results 2Luminex Corporation Reports Second Quarter 2014 results 3Luminex Corporation Reports Second Quarter 2014 results 4Luminex Corporation Reports Second Quarter 2014 results 5Luminex Corporation Reports Second Quarter 2014 results 6Luminex Corporation Reports Second Quarter 2014 results 7Luminex Corporation Reports Second Quarter 2014 results 8Luminex Corporation Reports Second Quarter 2014 results 9Luminex Corporation Reports Second Quarter 2014 results 10Luminex Corporation Reports Second Quarter 2014 results 11Luminex Corporation Reports Second Quarter 2014 results 12Luminex Corporation Reports Second Quarter 2014 results 13Luminex Corporation Reports Second Quarter 2014 results 14Luminex Corporation Reports Second Quarter 2014 results 15Luminex Corporation Reports Second Quarter 2014 results 16Luminex Corporation Reports Second Quarter 2014 results 17
... Reportlinker.com announces that a new market research ... Cancer Pain Therapeutics - ... http://www.reportlinker.com/p0546769/Cancer-Pain-Therapeutics---Pipeline-Assessment-and-Market-Forecasts-to-2017.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Pathology ... Assessment and Market Forecasts to 2017 ...
... YORK, June 1, 2011 ... market research report is available ... Interventional Neurology - ... and Market Forecasts to 2017 ...
Cached Medicine Technology:Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 2Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 3Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 4Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 5Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 6Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 7Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 8Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 9Reportlinker Adds Cancer Pain Therapeutics - Pipeline Assessment and Market Forecasts to 2017 10Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 2Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 3Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 4Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 5Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 6Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 7Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 8Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 9Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 10Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 11Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 12
... order tips. Each box contains 10,000 tips ... in easy-to-open, re-sealable Bulk Packs of 200 ... with a tamper-proof strip which can easily ... Diamond Tips. Bulk Packs are closed using ...
10 L, Bulk Recommended for 2, 5 and 10 L pipettes....
10 L, Bulk Recommended for 2, 5, 10 L pipettes....
... Theken eDISC is a revolutionary advancement in ... assess and manage their patients. The eDISC's ... the eDISC from 1st and 2nd generation ... loads of the lumbar spine, the eDISC ...
Medicine Products: