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Scientists from University of Hawaii at Manoa find genetic marker
Date:9/1/2009

of hundreds of thousands of genetic variations across the genome are compared between large numbers of cases and unaffected controls. Overall more than 20,000 women participated in this study.

In the first stage, more than 620,000 genetic variations were analyzed in the whole genome of 1,817 women with ovarian cancer and compared to 2,353 women without the disease. Through the Ovarian Cancer Association Consortium, the most promising markers were subsequently investigated among an additional 7,922 women with ovarian cancer and 10,577 women without disease.

The new marker was found on chromosome 9, close to the BNC2 (basonuclin 2) gene that encodes a protein which plays a role in regulation of DNA transcription and is highly expressed in reproductive tissues. This marker is present among 32% of women and contributes an estimated 0.7% to ovarian cancer risk.The association of this marker with risk was stronger for serous carcinoma, the most common (and most lethal) ovarian cancer subtype.


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Contact: Sharon Shigemasa
sharon@crch.hawaii.edu
808-586-3011
University of Hawaii at Manoa
Source:Eurekalert

Page: 1 2

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