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Scientists fixate on Ric-8 to understand trafficking of popular drug receptor targets
Date:12/28/2011

ell membrane. Without it, many of these proteins end up destroyed within the cell."

"Understanding more precisely how this important class of proteins operates in the body can perhaps make many of the drugs we use today more effective for patients," Tall added.

To do the study, Tall and colleagues had to devise a system where they could study the molecules in action. In living animals such as mice, when Ric-8 is knocked out completely, the animals die. So the team worked to identify a stem cell line in which the Ric-8 gene was knocked out, so they could study G protein function in the absence of Ric-8.


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Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2

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