Navigation Links
Scientists fixate on Ric-8 to understand trafficking of popular drug receptor targets
Date:12/28/2011

Half the drugs used today target a single class of proteins and now scientists have identified an important molecular player critical to the proper workings of those proteins critical to our health.

A protein known as Ric-8 plays a vital role, according to new results from a team led by Gregory Tall, Ph.D., assistant professor of Pharmacology and Physiology at the University of Rochester Medical Center. The work was published recently in Science Signaling.

What you see, what you smell, how you feel molecules known as G-protein coupled receptors and their prime targets, G proteins, are key to those and many other processes that are ubiquitous in our bodies. These proteins serve as the targets of drugs used to treat conditions like cancer, diabetes, depression, allergies, and heart disease.

These receptors normally weave themselves throughout the cell membrane, with one part protruding from the outside of a cell, and the rest of the protein inside the cell. When a compound like a drug or a hormone attaches to a receptor on the cell surface, it affects the G protein bound to the portion of the receptor that is inside the cell, triggering a cascade of signals that make life possible or improve health, in the case of a drug, or perhaps hurting health in the case of a toxin.

Previously, Tall discovered the existence of Ric-8 and learned that it binds to G proteins, which are made inside cells and have to make their way to the cell's outer edge, the membrane, to work correctly. In the new work, his team found that Ric-8 is a chaperone that G proteins need to be transported to the cell membrane. When Ric-8 is knocked out, G proteins don't work as they should and are destroyed.

"G proteins are involved in many biological processes how we see and taste, how our heart beats, even our mood," said Tall. "It's a very important class of proteins. Ric-8 is the chaperone that gets G proteins where they need to be, to the cell membrane. Without it, many of these proteins end up destroyed within the cell."

"Understanding more precisely how this important class of proteins operates in the body can perhaps make many of the drugs we use today more effective for patients," Tall added.

To do the study, Tall and colleagues had to devise a system where they could study the molecules in action. In living animals such as mice, when Ric-8 is knocked out completely, the animals die. So the team worked to identify a stem cell line in which the Ric-8 gene was knocked out, so they could study G protein function in the absence of Ric-8.


'/>"/>
Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Related medicine news :

1. NOAA scientists: spilled oil unexpectedly lethal to fish embryos in shallow, sunlit waters
2. Rare brain disorder may be more common than thought, say Mayo Clinic scientists
3. Scientists Ponder Santas High-Tech Secrets
4. Scientists Probe the Origins of Dyslexia
5. UCLA neuroscientists demonstrate crucial advances in brain reading
6. Buildup of Newer Flame Retardants Concerns Scientists
7. NIH scientists find a potential new avenue for cancer therapies
8. Scientists may be able to double efficacy of radiation therapy
9. Missouri Botanical Garden scientists examine toxicity of medicinal plants in Peru
10. Scientists develop vaccine that successfully attacks breast cancer in mice
11. Scientists develop vaccine that attacks breast cancer in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2017)... ... 19, 2017 , ... First Choice Emergency Room , the largest network ... the new Medical Director of its Pflugerville- FM 685 facility. , “We are ... Pflugerville- FM 685 location,” said Dr. Stephen Van Roekel, Reginal Medical Officer of First ...
(Date:9/19/2017)... ... 2017 , ... Ron Norman, CEO of Team Decades, http://www.teamdecades.com , stressed ... rather than generic impression in the job market if one is looking for career ... knows that the first impression they give off is not a good one," says ...
(Date:9/19/2017)... ... 19, 2017 , ... When it comes to household safety, there are few ... how to keep babies and toddlers safe, and there's no better time for companies ... Time to Check Labels, Brands that sell all kinds of common consumer products should ...
(Date:9/19/2017)... ... 2017 , ... MarkeTouch Media has partnered with fred’s Pharmacy ... modern design with a more streamlined user experience and is designed to improve ... includes hundreds of digital coupons that can be clipped to a customer’s account ...
(Date:9/19/2017)... ... September 19, 2017 , ... With Netmail Hadron, ... the United States, can easily manage all of their data, apply policies on ... platforms simultaneously. “As a construction company,” says Ryan Sinnwell, the Infrastructure Manager at ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... 8, 2017 ... Unit coming to Washington DC ... When: Tuesday, September 12 th – Monday, September 18 th .The ... free MRI brain scans to the public.Where:  BTF,s ... at 501 K Street NW, Washington, D.C.What:BTF brings its nationwide initiative, the ...
(Date:9/7/2017)... , Sept. 7, 2017 Caris ... focused on fulfilling the promise of precision medicine, ... validate the benefits of its molecular profiling approach ... utilized comprehensive genomic profiling plus (CGP+) with Caris ... patient,s tumor on a molecular level, leading to ...
(Date:9/6/2017)... , Sept. 6, 2017  Medical professionals ... and skills while treating their patients. Medical ... experience without involving patients. Simulation provides a ... can carry out procedures, refine techniques and ... Integration of new technology, such as augmented ...
Breaking Medicine Technology: