Navigation Links
Scientists fixate on Ric-8 to understand trafficking of popular drug receptor targets
Date:12/28/2011

Half the drugs used today target a single class of proteins and now scientists have identified an important molecular player critical to the proper workings of those proteins critical to our health.

A protein known as Ric-8 plays a vital role, according to new results from a team led by Gregory Tall, Ph.D., assistant professor of Pharmacology and Physiology at the University of Rochester Medical Center. The work was published recently in Science Signaling.

What you see, what you smell, how you feel molecules known as G-protein coupled receptors and their prime targets, G proteins, are key to those and many other processes that are ubiquitous in our bodies. These proteins serve as the targets of drugs used to treat conditions like cancer, diabetes, depression, allergies, and heart disease.

These receptors normally weave themselves throughout the cell membrane, with one part protruding from the outside of a cell, and the rest of the protein inside the cell. When a compound like a drug or a hormone attaches to a receptor on the cell surface, it affects the G protein bound to the portion of the receptor that is inside the cell, triggering a cascade of signals that make life possible or improve health, in the case of a drug, or perhaps hurting health in the case of a toxin.

Previously, Tall discovered the existence of Ric-8 and learned that it binds to G proteins, which are made inside cells and have to make their way to the cell's outer edge, the membrane, to work correctly. In the new work, his team found that Ric-8 is a chaperone that G proteins need to be transported to the cell membrane. When Ric-8 is knocked out, G proteins don't work as they should and are destroyed.

"G proteins are involved in many biological processes how we see and taste, how our heart beats, even our mood," said Tall. "It's a very important class of proteins. Ric-8 is the chaperone that gets G proteins where they need to be, to the cell membrane. Without it, many of these proteins end up destroyed within the cell."

"Understanding more precisely how this important class of proteins operates in the body can perhaps make many of the drugs we use today more effective for patients," Tall added.

To do the study, Tall and colleagues had to devise a system where they could study the molecules in action. In living animals such as mice, when Ric-8 is knocked out completely, the animals die. So the team worked to identify a stem cell line in which the Ric-8 gene was knocked out, so they could study G protein function in the absence of Ric-8.


'/>"/>
Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Related medicine news :

1. NOAA scientists: spilled oil unexpectedly lethal to fish embryos in shallow, sunlit waters
2. Rare brain disorder may be more common than thought, say Mayo Clinic scientists
3. Scientists Ponder Santas High-Tech Secrets
4. Scientists Probe the Origins of Dyslexia
5. UCLA neuroscientists demonstrate crucial advances in brain reading
6. Buildup of Newer Flame Retardants Concerns Scientists
7. NIH scientists find a potential new avenue for cancer therapies
8. Scientists may be able to double efficacy of radiation therapy
9. Missouri Botanical Garden scientists examine toxicity of medicinal plants in Peru
10. Scientists develop vaccine that successfully attacks breast cancer in mice
11. Scientists develop vaccine that attacks breast cancer in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at ... of the most popular and least understood books in the Holy Scriptures, Revelation. The ... that have baffled scholars for centuries. Many have tossed it off as mere rubbish, ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s to ... and tested to meet the highest standard. , These products are also: ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: , ... to enable prevention of a major side effect of chemotherapy in children. Cisplatin ... patients. For cisplatin, hearing loss is FDA listed on-label as a dose limiting ...
(Date:10/12/2017)... ... 12, 2017 , ... On Saturday, October 21, the Health & Wellness Center ... to raise money for the American Heart Association Heart Walk. Teams of up to ... together to keep their treadmills moving for 5 hours. Treadmills will start at 7:00 ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... 2017 AVACEN Medical , Inc. (AVACEN) announced ... 2017 New Product Innovation Award for Its fibromyalgia pain ... secondary medical device market research by Frost & Sullivan,s industry ... drug-free pain relief product, the AVACEN 100, offers a safe ... widespread pain. ...
(Date:10/12/2017)... , Oct. 12, 2017 West ... in innovative solutions for injectable drug administration, today announced ... the market opens on Thursday, October 26, 2017, and ... results and business expectations at 9:00 a.m. Eastern Time. ... or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)... , Oct. 11, 2017  Caris Life Sciences ... on fulfilling the promise of precision medicine, today announced ... joined Caris, Precision Oncology Alliance™ (POA) as its 17 ... centers, the St. Jude Crosson Cancer Institute will help ... the use of tumor profiling, making cancer treatment more ...
Breaking Medicine Technology: